 
 
 
 INSIGHTi 
 
Illicit Fentanyl and Weapons of Mass 
Destruction: International Controls and Policy 
Options 
March 28, 2022 
As synthetic opioid overdose deaths in the United States reac
h historic levels, some policy stakeholders 
have sought U.S. action in
 designating fentanyl as a weapon of mass destruction (WMD). S
uch calls have 
also prompted congressional
 interest. Although a statutory designation of fentanyl as a WMD does not 
appear necessary for additional executive branch action to address fentanyl as an illicit drug or chemical 
weapon, Congress may consider developing legislation to improve upon perceived shortcomings in the 
U.S. government’s approach to addressing fentanyl. 
Background 
Various observers draw rhetorical comparisons between fentanyl abuse and WMDs. For example, the 
congressionally
 mandated Commission on Combating Synthetic Opioid Trafficking
 assessed in February 
2022 that “[i]n terms of loss of life and damage to the economy, illicit synthetic opioids have the effect of 
a slow-motion weapon of mass destruction.”  
Others, including som
e Members of Congress, note the possible use of fentanyl as a weapon; in media 
reports, observers have speculated that fentanyl’s increasing availability may prompt U.S. adversaries and 
non-state actors to weaponize the drug.  
Governments have also recently committed to restricting the use of central nervous system-acting (CNS) 
chemicals, including fentanyl, in law enforcement and other security operations. (In 2002, the Russian 
military
 reportedly deployed an aerosolized form of fentanyl to incapacitate terrorists holding hostages in 
a Moscow theater; the gas al
so killed more than 120 of the hostages.) 
Narcotics Controls  
Most U.S.-consumed illicit fentanyl is foreign-sourced—and combating such foreign production and 
U.S.-destined trafficking flows remains an ongoing congressional topic of oversight and legislation. 
Within the past three years,
 Mexico has emerged as the primary source and transit point for illicit fentanyl 
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into the United States. Producers of illicit fentanyl mostly source precursor chemicals from Asian 
countries, especially China.  
Fentanyl is subject to strict international controls that limit its legal use for medical and scientific 
purposes. Pursuant to the Single Convention on Narcotics Drugs of 1961, as amended (to which 154 
countries are party, including the United States), more than two dozen additional fentanyl variants 
(analogues) are also subject to international controls. Several chemical inputs (precursors) used in the 
production of fentanyl are also subject to international controls under Table I of the 1988 Convention 
Against Illicit Traffic of Narcotics Drugs and Psychotropic Substances (191 states parties, including the 
United States). In the United States, fentanyl and its key precursors are also subject to domestic regulatory 
control.  
On December 15, 2021, President Joe Biden issu
ed Executive Order 14059, which declared a national 
emergency with respect to international trafficking of illegal drugs, including “fentanyl and other 
synthetic opioids.” Invoking the International Emergency Economic Powers Act (IEEPA; 50 U.S.C. 
§§1701 et seq.), this order authorizes the Secretary of the Treasury to impose a variety of sanctions on 
foreign persons engaging in listed activities related to “the international proliferation of illicit drugs or 
their means of production.”  
Chemical Weapons Controls 
The Chemical Weapons Convention (CWC), which has 193 states parties, including the United States, 
prohibits the development, production, transfer, stockpiling, and use of chemical and toxin weapons—and 
certain precursors. The CWC contains three schedules of chemicals “identified for the application of 
[CWC] verification measures,” but the aforementioned treaty prohibitions also apply to unscheduled 
chemicals. The convention includes several provisions requiring states parties to regulate the transfer of 
chemicals that could be used for chemical weapons purposes.  
The CWC permits the use of chemicals otherwise prohibited under the treaty for “domestic riot control 
purpose.” However, a December 1, 2021, CWC states partie
s statement clarified that such permitted use 
does not include the “aerosolised use” of CNS chemicals, such as fentanyl. A 2018 OPCW Scientific 
Advisory Boar
d report explained that aerosolized use of such chemicals in law enforcement has “resulted 
in permanent harm and death due to an irreversible action on life processes.” 
U.S. law prohibits activities concerning chemical weapons, including trafficking in or producing 
weaponized fentanyl. For example, Section 229 of the Chemical Weapons Convention Implementation 
Act of 1998 
(P.L. 105-277; 18 U.S.C. §229) forbids producing, transferring, and using chemical weapons.  
Selected Proposals 
Role of DHS’s CWMD Office 
On February 22, 2019, the Department of Homeland Security’s (DHS’s) Assistant Secretary for 
Countering Weapons of Mass Destruction (CWMD) circulated a memorandum advocating the use of 
“appropriate CWMD authorities against fentanyl.” Ma
de public by 
Task and Purpose, the memorandum 
explains that the CWMD Office, scheduled to terminate in December 2023, could apply its “assets and 
capabilities to the fentanyl problem through the lens of WMD.” The Homeland Security Act of 2002, as 
amended 
(P.L. 107-296; 6 U.S.C. §§101, et seq.), which established the CWMD Office, lacks a provision 
for classifying fentanyl as a WMD. 
  
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For FY2021, DHS proposed a program change to the Regional Medical Operations Group (RMOG), a 
part of the CWMD Office. The group’s tasks would have included “filling information gaps into 
investigations and responses to fentanyl or ricin.” DHS’s FY2022 budget request did not contain such a 
proposal, the intended impact of which is unclear. According to DHS, RMOG is a regionalized network of 
CWMD federal personnel who possess “qualifications primarily in medicine and public health.”  
DOD Designation 
The DHS memo published by 
Task and Purpose in 2019 also stated that senior Defense Department 
(DOD) leaders “have proposed formally designating fentanyl as a WMD material.” Definitions in current 
law (e.g
., 50 U.S.C. §2302 and 18 U.S.C. §2332a) broadly cover weapons that can cause mass casualties 
through the release of “toxic or poisonous weapons or their precursors” as well as biological and 
radioactive materials, but do not list specific substances of concern, including fentanyl. 
Executive Order 
In July 2021, an advocacy organization sent an
 open letter, which included high-level former officials as 
signatories, to President Biden, requesting that he identify fentanyl as a WMD by executive order. This 
organization has argued elsewhere that President Biden should issue such a designation pursuant to the 
authorities in IEEPA, which provides the President broad authority to regulate a variety of economic 
transactions following a declaration of national emergency. As noted, President Biden’s December 2021 
Executive Order declared a national emergency with respect to international trafficking of illicit narcotics, 
including fentanyl. Congress may consider whether to pursue the matter further through legislation and 
oversight. 
 
 
 
Author Information 
 Paul K. Kerr 
  Liana W. Rosen 
Specialist in Nonproliferation  
Specialist in International Crime and Narcotics 
 
 
 
 
 
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