Regional Innovation: Federal Programs and Issues for Consideration

Regional Innovation: Federal Programs and Issues for Consideration

Regional Innovation: Federal Programs and
April 3, 2023
Issues for Consideration
Julie M. Lawhorn
In recent years, Congress has increased support for economic development policies that
Analyst in Economic
incorporate a regional innovation systems (RIS) approach. RIS are composed of public and
Development Policy
private sector partners, including educational and research institutions, investors, firms, economic

development organizations, and entrepreneurs, among others. The RIS approach seeks to develop
Marcy E. Gallo
an ecosystem that fosters linkages between organizations so that a region may increase jobs,
Analyst in Science and
attract investment, and otherwise support economic development and related goals.
Technology Policy
The rationale for increased federal involvement in developing connected, innovative regional

economies is often associated with concerns that the United States is ceding its global technology
Adam G. Levin
and economic competitiveness position, in particular relative to China. Proponents of RIS
Analyst in Economic
policies also view the approach as a means of addressing regional barriers to innovation and
Development Policy
entrepreneurship and strengthening the capacity of regional stakeholders. Some policymakers and

analysts consider federal support for RIS as a way to help revitalize and restructure places and
regional economies that have been impacted by globalization and international trade. Others
Emily G. Blevins
emphasize the spread of innovation and bolstering innovation capacity in specific regions as a
Analyst in Science and
means of creating well-paying jobs and combating socioeconomic and regional disparities.
Technology Policy

While federal involvement in RIS began to expand in the mid-2000s, multiple Administrations
and Congress have continued to take action to increase the size and scope of federal investments

in the approach. In July 2021, the Economic Development Administration (EDA, in the
Department of Commerce) allocated $1 billion of supplemental funding for economic recovery activities to the Build Back
Better Regional Challenge, a new grant initiative to support new or existing regional industry clusters. With the enactment of
the CHIPS and Science Act (P.L. 117-167) in August 2022, Congress required the establishment of a number of new regional
innovation programs, including the Regional Technology and Innovation Hubs program at EDA, the Regional Innovation
Engines program at the National Science Foundation (NSF), and the Regional Clean Energy Innovation program at the
Department of Energy (DOE). Through recent annual appropriations, Congress has also directed agencies to allocate funding
to existing RIS programs such as EDA’s Build to Scale, DOE’s Energy Program for Innovation Clusters, and the Small
Business Administration’s Regional Innovation Clusters programs, among others.
In light of this recent legislation, the 118th Congress may consider options to expand the federal role in the development of
RIS or make adjustments to the scope and scale of RIS assistance. Congress may also consider enhanced oversight of how
new and existing regional innovation programs are implemented and how they are coordinated between federal agencies and
across multiple levels of government. Congress may be interested in reviewing options to integrate the assistance and
services provided by other federal programs, such as capital access, infrastructure, and existing research institutions, with
certain RIS grantees. Coordination issues that may warrant further review include aligning RIS programs with other federal
efforts designed to prepare a STEM-capable (science, technology, engineering, and mathematics) workforce, building the
capacity of support organizations in under-resourced and disadvantaged communities, and expanding access to capital for
entrepreneurs. In addition, Congress may seek ways to better evaluate the outcomes of strategies used to address
socioeconomic and regional disparities when considering their possible use in other place-based development policies.
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Contents
Introduction ..................................................................................................................................... 1
Regional Innovation Systems (RIS) .......................................................................................... 2
Increased Federal Attention and Assistance for Regional Innovation ....................................... 5
Federal Regional Innovation Programs ........................................................................................... 6
National Science Foundation (NSF) ......................................................................................... 7
Regional Innovation Engines Program ............................................................................... 7
Department of Commerce ......................................................................................................... 8
Regional Technology and Innovation Hub Program ........................................................... 8
Recompete Pilot Program ................................................................................................... 9
Build to Scale (formerly “Regional Innovation Strategies”) ............................................ 10
Economic Recovery Funding for Innovation Initiatives ................................................... 12
Manufacturing USA .......................................................................................................... 12
Department of Energy Programs ............................................................................................. 13
Energy Program for Innovation Clusters (EPIC) Program ............................................... 13
Regional Clean Energy Innovation Program .................................................................... 14
Additional DOE Hub Programs for Technology Commercialization ............................... 15
Small Business Administration ............................................................................................... 15
Regional Innovation Clusters Program ............................................................................. 15
Additional Programs and Support for Regional Innovation Systems ..................................... 16
Considerations for Congress.......................................................................................................... 17
Scale, Scope, and Duration of Federal Investments ................................................................ 17
Coordination of Federal Regional Innovation Investments .................................................... 18
Interagency Coordination .................................................................................................. 18
EDA Roles and Resources ...................................................................................................... 20
Data for Decisionmaking and Capacity-Building ................................................................... 21
RIS Governance Considerations ....................................................................................... 22
Equity and Innovation ............................................................................................................. 23
Capital Access ......................................................................................................................... 25
Startups and Small Business Considerations .......................................................................... 27
Concluding Remarks ..................................................................................................................... 28

Figures
Figure 1. Regional Innovation System Stakeholders ....................................................................... 4
Figure 2. Selected RIS Program Awards and Facilities, by Location ............................................. 11
Figure 3. Comparison of NSF Regional Innovation Engines and EDA Regional
Technology and Innovation Hub Programs ................................................................................ 19
Figure 4. U.S. Patent and Trademark Office (USPTO) Utility Patents Granted to U.S.
Owners per 1,000 Residents, by U.S. County: 2020 .................................................................. 25

Contacts
Author Information ........................................................................................................................ 28

Congressional Research Service

Regional Innovation: Federal Programs and Issues for Consideration

Introduction
Economists widely recognize technological advancement as one of the most important sources of
productivity growth and long-term economic growth.1 The development of new technologies and
the improvement of existing ones can contribute to the economy through the creation of new
goods and services, new industries, and new jobs. Technological progress is achieved through
innovation—a process that may involve, among other activities, idea origination, research,
development, commercialization, adaptation, and diffusion.2 Some technological changes may
also negatively affect workers, businesses, and communities. For example, automation may
contribute to regional job losses or businesses may close because their products become obsolete
or they fail to keep up with advances in manufacturing techniques.
For decades, federal policies have supported innovation, including by providing financial
assistance (e.g., grants and tax credits) for research and development (R&D); supporting science,
technology, engineering, and mathematics (STEM) education, training, and workforce
development; and facilitating public-private R&D partnerships, among others.3 However,
innovation and economic growth based on technological progress vary across the nation with
high-income groups and a few selected cities receiving most of the economic gains.4
According to some experts, such demographic and geographic disparities in innovation and
economic growth have the potential to seriously disadvantage the long-term competitiveness of
the United States.5 Policymakers and outside groups suggest that integrating place-based
economic development policies with innovation policies may address concerns about
competitiveness and disparities by strengthening innovation economies at the regional level. For
example, the National League of Cities (NLC) states that “a fundamentally missing piece of
federal research and economic policy is a focus on the innovation and entrepreneurial capacity of
specific places.”6 State, regional, and local economic development practitioners have
implemented place-based innovation strategies, like the ones described by the NLC, for decades.7

1 For an overview of concepts related to economic growth and factors that impact an economy’s productive capacity,
see “Economic Growth” in CRS In Focus IF10408, Introduction to U.S. Economy: GDP and Economic Growth, by
Mark P. Keightley and Lida R. Weinstock, and CRS In Focus IF10557, Introduction to U.S. Economy: Productivity, by
Lida R. Weinstock.
2 According to a report by the Congressional Budget Office (CBO), “broadly speaking, an innovation is a new or
significantly improved product or process.” See CBO, Federal Policies and Innovation, November 2014, p.
5, https://www.cbo.gov/sites/default/files/113th-congress-2013-2014/reports/49487-Innovation.pdf.
3 For more information on select science, technology, and innovation issues, federal science agencies, and associated
CRS experts, see CRS Report R47373, Science and Technology Issues for the 118th Congress, coordinated by Frank
Gottron and Jason A. Gallo.
4 Robert D. Atkinson, Mark Muro, and Jacob Whiton, The Case for Growth Centers: How to Spread Tech Innovation
Across America, The Brookings Institution and The Information Technology and Innovation Foundation, Washington,
DC, December 8, 2019, https://www.brookings.edu/research/growth-centers-how-to-spread-tech-innovation-across-
america/.
5 Ibid.
6 Scott Andes, Place-Based Policies for America’s Innovation Economy, National League of Cities, 2019,
https://www.nlc.org/wp-content/uploads/2019/11/Place-Based-Paper_1.pdf.
7 Arizona’s Science Foundation Arizona and Ohio’s Third Frontier initiatives are examples of state support for the
Regional Innovation Systems (RIS) approach and are noted in Mark Muro and Bruce Katz, “The New ‘Cluster
Moment’: How Regional Innovation Clusters Can Foster the Next Economy,” The Brookings Institute, Metropolitan
Planning Institute, September 2010. Additional state-led RIS initiatives are listed in the following report: Karen G.
Mills, Elisabeth B. Reynolds, and Andrew Reamer, Clusters and Competitiveness: A New Federal Role for Stimulating
Regional Economies, The Brookings Institution, April 2008, p. 4, https://www.brookings.edu/wp-content/uploads/
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Regional Innovation: Federal Programs and Issues for Consideration

In recent years, congressional interest in developing regional innovation systems (RIS) has grown
steadily. Additionally, congressional support for RIS policies indicates further interest in ensuring
that disparate regional economies have resources to enhance their RIS capacity.
This report describes the potential for RIS (and other place-based innovation policies) to facilitate
the growth of firms, regional economies, and national economic and competitiveness interests. It
also discusses the portfolio of federal programs and activities in support of regional innovation
objectives, including a number of new regional innovation programs enacted across multiple
federal agencies in P.L. 117-167, often referred to as the CHIPS and Science Act. The report
focuses on RIS programs administered by the National Science Foundation, the Department of
Commerce, the Department of Energy, and the Small Business Administration. Programs and
other initiatives administered by the Departments of Defense and Labor and the National
Institutes of Health are not included, but may contribute to regional economic development or
support components of RIS (e.g., workforce development). Additionally, programs and other
initiatives administered by federal regional commissions and authorities are not included;
however, these entities are often involved in the implementation of regional economic
development strategies.8 Selected considerations for Congress with regard to the implementation
and oversight of regional innovation programs and activities are presented at the end.
Regional Innovation Systems (RIS)
Over time, economic development policies at multiple levels of government have evolved to
support more innovation- and technology-based economic development (TBED) strategies.9
TBED strategies are based on the premise that—in addition to physical capital, human capital,
and natural resources—innovation and technological advancement drive economic growth.10 In
other words, knowledge- and technology-based firms can be generators of new ideas, processes,
products, or services, which then contribute to increased productivity and economic growth.
Policymakers and economic development practitioners sometimes support TBED strategies, in
part, because average wages for STEM workers associated with high-tech firms generally exceed
those for workers at non-high-tech firms.11 While TBED strategies emphasize growth associated

2016/07/Clusters-Brief.pdf.
8 For more information on federal regional commissions and authorities, see CRS Report R45997, Federal Regional
Commissions and Authorities: Structural Features and Function, by Julie M. Lawhorn.
9 Organization for Economic Cooperation and Development, Reviews of Regional Innovation, Regions and Innovation
Policy, 2011, p. 33. Technology-based economic development (TBED) is one of seven investment priorities of the
Economic Development Administration (EDA, an agency in the Commerce Department) and is defined by EDA as
“economic development planning or implementation projects that foster regional knowledge ecosystems that support
entrepreneurs and startups, including the commercialization of new technologies, that are creating technology-driven
businesses and high-skilled, well-paying jobs of the future.” See EDA, “Investment Priorities,” https://www.eda.gov/
funding/investment-priorities.
10 See “Economic Growth” in CRS In Focus IF10408, Introduction to U.S. Economy: GDP and Economic Growth, by
Mark P. Keightley and Lida R. Weinstock.
11 Brian Roberts and Michael Wolf, “High-Tech Industries: An Analysis of Employment, Wages, and Output,” Beyond
the Numbers: Employment and Unemployment, vol. 7, no. 7 (U.S. Bureau of Labor Statistics (BLS), May
2018), https://www.bls.gov/opub/btn/volume-7/high-tech-industries-an-analysis-of-employment-wages-and-
output.htm. The report notes that high-tech industries were defined in a 2016 BLS article “as those having high
concentrations of workers in STEM (Science, Technology, Engineering, and Mathematics) occupations.” The report
further notes that, “There are alternative methods of defining high-tech industries, based on R&D expenditures, patents,
and other metrics.” Additionally, researchers and practitioners also use the term “advanced industries.” For a definition
and examples of advanced industries, see Mark Muro et al., America’s Advanced Industries: What They Are, Where
They Are, and Why They Matter, The Brookings Institute, February 3, 2015, https://www.brookings.edu/research/
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with technology firms, innovation can occur in any sector, including healthcare, education, or
manufacturing (e.g., steel, textiles).12
The RIS approach is a place-based form of TBED. Experts define RIS as “interacting knowledge
generation and exploitation subsystems linked to global, national, and other regional systems,”13
as well as the “institutional infrastructure supporting innovation within the production structure of
a region.”14 As conveyed by these and other definitions, the RIS approach involves private
industry and public sector partners coordinating efforts to develop and grow regional economies
and employment bases through the development, application, and diffusion of technological and
business knowledge. Researchers and government agencies consider certain actors, networks, and
institutions—including research institutions, private sector firms, government agencies, investors,
and entrepreneurs—as components of innovation “ecosystems” that are integral to the
development of RIS.15 The EDA defines a region as a geographic area based on economic and
demographic patterns that may cross municipal and state boundaries.16 Figure 1 shows the
stakeholders and activities generally involved in the implementation of RIS.

americas-advanced-industries-what-they-are-where-they-are-and-why-they-matter/.
12 The Economic Development Administration’s (EDA’s) definition of innovation further notes that it may occur
within all aspects of the economic development ecosystem. See EDA, “Key Definitions,” https://eda.gov/performance/
key-definitions/.
13 Philip N. Cooke, “Regional Innovation Systems—An Evolutionary Approach,” in Regional Innovation Systems: the
Role of Governance in a Globalized World, 2nd ed., eds., Philip Cooke, Martin Heidenreich, and Hans-Joachim
Braczyk. (London: Routledge, 2004), p. 3.
14 Bjørn T. Asheim and Lars Coenen, “Knowledge Bases and Regional Innovation Systems: Comparing Nordic
Clusters,” Research Policy, vol. 34, no. 8, (October 2005), p. 1177.
15 Experts generally use a broad perspective to describe RIS as encompassing all regional economic, social, and
institutional factors that affect the innovativeness of firms. Such RIS are composed of firms, universities, public and
private research organizations, technology mediating organizations, workforce organizations, and educational
organizations. For additional definitions and analysis of RIS, see Bjørn T. Asheim, Arne Isaksen, and Michael Trippl,
Advanced Introduction to Regional Innovation Systems (Northampton, MA: Edward Elgar Publishing, 2019); Björn T.
Asheim, Markus Grillitsch, and Michaela Trippl, “Regional Innovation Systems: Past—Present—Future,” in Handbook
on the Geographies of Innovation (Northampton, MA: Edward Elgar, 2016), pp. 48-49; F. Hu, “Study on the Roles and
Responsibilities of Government in the Regional Innovation System,” in Frontiers in Enterprise Integration (CRC
Press, 2008), p. 382, https://www.taylorfrancis.com/chapters/edit/10.1201/9781003061090-58/study-roles-
responsibilities-government-regional-innovation-system-hu; Lars Coenen and Kevin Morgan, “Evolving Geographies
of Innovation: Existing Paradigms, Critiques and Possible Alternatives,” Norsk Geografisk Tidsskrift—Norwegian
Journal of Geography, vol. 74, no. 1, 2020, pp. 13-24, https://www.tandfonline.com/doi/full/10.1080/
00291951.2019.1692065; and Franz Tödtling, Michaela Trippl, and Veronika Desch, “New Directions for RIS Studies
and Policies in the Face of Grand Societal Challenges,” European Planning Studies, vol. 30, no. 11, 2022, pp. 2139-
2156, https://doi.org/10.1080/09654313.2021.1951177.
16 EDA, “Key Definitions,” https://eda.gov/performance/key-definitions/.
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Figure 1. Regional Innovation System Stakeholders

Source: CRS.
Notes: Accelerator programs help existing businesses start new initiatives, expand into new markets, or
accelerate growth. Incubator programs provide services to assist with business formation and the development
of new products and services. See Minority Business Development Agency, “MBDA Capital Readiness Program,”
https://www.mbda.gov/mbda-capital-readiness-program. Testbeds provide conditions for analyzing a product or
service before it is commercialized and may be in real or simulated environments or laboratories. Physical assets
include facilities, buildings, equipment, and infrastructure that may be used in developing RIS and facilitating
economic development.
The geographic dimension of where and how knowledge and technology firms interact with each
other and with other stakeholders is central to the development of RIS. Geographic concentrations
of interconnected companies and institutions can provide an opportunity to leverage talent,
infrastructure, supply chains, and other spillover effects that are advantageous to companies and
economic growth.17 RIS are often designed to build on place-based assets, such as research
universities, or to address structural or institutional challenges that face an area’s entrepreneurs
and innovators (e.g., access to capital). In the United States, RIS are generally planned and
implemented at the state, local, or regional level; instead of using a federally led approach.
Advocates for this approach assert that it is both place-sensitive and community-driven. In some
instances in certain countries, RIS policies may be centrally planned, or may feature thematic or
sectoral priorities selected by national governments or public-private partnerships.18

17 Philip Cooke, “Strategies for Regional Innovation Systems: Learning, Transfer and Applications,” United Nations
Industrial Development Organization, 2003.
18 Analysis of RIS policies outside of the United States is beyond the scope of this report. For additional analysis of RIS
policies in other settings, see, for example, Bjørn T. Asheim, Arne Isaksen, and Michael Trippl, Advanced Introduction
to Regional Innovation Systems (Northampton, MA: Edward Elgar Publishing, 2019); OECD, Reviews of Regional
Innovation, Regions and Innovation Policy, 2011; and Philip Cooke, Martin Heidenreich, and Hans-Joachim Braczyk,
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RIS strategies also overlap with another TBED strategy that focuses on developing industry
clusters—“companies, specialized suppliers, service providers, firms in related industries, and
associated institutions (e.g., universities, standards agencies, trade associations) in a particular
field that compete but also cooperate.”19 Cluster development efforts are often designed to
facilitate the co-location of related firms in a particular area, but not necessarily with a focus on
innovation. The RIS approach generally focuses on facilitating innovation clusters and reflects
the premise that places, and regions in particular, have a role in fostering innovation.20
Increased Federal Attention and Assistance for Regional Innovation
State, local, and regional stakeholders have pursued cross-sector, multidisciplinary approaches to
economic development and RIS for decades. However, many regard the federal role in place-
based RIS as limited in size, scope, and coordination prior to the mid-2000s.21 For example,
federal efforts in the late 1970s and 1980s focused primarily on facilitating the transfer of
federally developed technologies to states and the private sector, and on encouraging
collaborative research and development activities, broadly (without a regional or place-based
emphasis).22
Federal involvement in a RIS approach expanded starting in the mid-2000s. In 2009, the Obama
Administration published a national innovation strategy that included support for regional
innovation clusters.23 During this time, multiple federal agencies increased support for industry
clusters and regional innovation initiatives—several of which leveraged recently authorized
programs and funding from the American Recovery and Reinvestment Act of 2009 (P.L. 111-5).24

eds., Regional Innovation Systems: the Role of Governance in a Globalized World, 2nd ed. (London: Routledge, 2004).
19 Michael C. Porter, “Location, Competition, and Economic Development: Local Clusters in a Global Economy,”
Economic Development Quarterly, vol. 14, no. 1, February 2000, pp. 16, 19-20. See also Mark Muro and Bruce Katz,
“How Regional Innovation Clusters Can Foster the Next Economy,” Brookings Institution, 2010,
https://www.brookings.edu/wp-content/uploads/2016/06/0921_clusters_muro_katz.pdf.
20 Researchers have further distinguished clusters from RIS by noting that, “RIS overlaps with but is different from a
cluster. Clusters are central elements of the knowledge application and exploitation subsystem, whilst the RIS is a
wider concept in the sense (1) that there are usually several clusters and many industries in a RIS and (2) that
institutions play a larger role.” See Franz Tödtling and Michaela Trippl, “One Size Fits All? Towards a Differentiated
Regional Innovation Policy Approach,” Research Policy, vol. 34, 2005, pp. 1203-1219.
21 Some analysts regard the national approach to innovation policy in the United States as decentralized and note that
states historically have led the development of innovation strategies at the subnational level. A review of national or
federal innovation policy is beyond the scope of this report. For a summary of post-WWII milestones in national
innovation policy, see Robert Atkinson, “Understanding the U.S. National Innovation System,” Information
Technology Innovation Foundation, November 2, 2020, https://itif.org/publications/2020/11/02/understanding-us-
national-innovation-system-2020/; and Philip Shapira and Jan Youtie, “The Innovation System and Innovation Policy
in the United States,” in Competing for Global Innovation Leadership: Innovation Systems and Policies in the USA, EU
and Asia, ed. Rainer Friestch and Margot Schüller (Stuttgart, Germany: Fraunhofer Verlog, 2010). For a review of the
evolution of and the study of regional innovation systems, see Bjørn T Asheim, Arne Isaksen, and Michael Trippl,
Advanced Introduction to Regional Innovation Systems (Northampton, MA: Edward Elgar Publishing, 2019), pp. 13-
22.
22 See, for example, the Stevenson-Wydler Technology Innovation Act of 1980 (P.L. 96-480); the Government Patent
Policy Act (P.L. 96-517, commonly referred to as the “Bayh-Dole Act”); the Federal Technology Transfer Act of 1986
(P.L. 99-502); and the creation of the National Science Foundation’s Industry–University Cooperative Research
Centers (IUCRC) and Engineering Research Centers (ERC) programs.
23 White House, “A Strategy for American Innovation: Driving Towards Sustainable Growth and Quality Jobs,”
October 2015, https://obamawhitehouse.archives.gov/sites/default/files/
strategy_for_american_innovation_october_2015.pdf.
24 See, for example, the solicitation for applications under the EDA’s American Recovery Act Program at
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In subsequent years, support for RIS expanded through congressional authorization and
appropriations. For example, in 2011, Congress established the Regional Innovation Program
(now called the Build to Scale Program; discussed in more detail below) through the America
COMPETES Reauthorization Act of 2010 (P.L. 111-358); appropriations for the program
increased from $10 million in FY2014 to $50 million in FY2023.25 Similarly, the enactment of
P.L. 117-167 (the CHIPS and Science Act) in 2022 marked another significant increase in support
for RIS policies due to the authorization of several new programs at various federal agencies.
Notably, P.L. 117-167 authorized $10 billion to be appropriated over five years for the new
Department of Commerce Regional Innovation and Technology Hubs program and additional
amounts for programs administered by the National Science Foundation, the Department of
Energy, and other agencies (discussed in detail below).26
Federal support for RIS may be based on one or more objectives. The rationale for regional
innovation programs is often framed as one aspect of a broader strategy for strengthening U.S.
global technological and economic competitiveness, particularly in relation to China.27
Additionally, support for federal involvement in the RIS approach is often based on a view of the
U.S. economy as a collection of subnational, regional economies. According to this view, stronger
regional economies contribute to a more resilient national economic position; policymakers may
focus on innovation and technology in particular due to the expectation of growth associated with
these activities and industries.28 Some policymakers and analysts also view federal support for
RIS as a means of addressing challenges related to revitalizing and restructuring places and
regional economies that have been impacted by globalization and international trade.29 Others
emphasize the spread of innovation and bolstering innovation capacity in specific regions as a
means of creating well-paying jobs and combating socioeconomic and regional disparities.30
Federal Regional Innovation Programs
Administration and legislative actions indicate continued federal interest and support for
developing RIS. The following sections provide descriptions of select programs focused on

https://www.grants.gov/web/grants/view-opportunity.html?oppId=45786.
25 For a summary of EDA appropriations by program, see Table B-2. Funding for EDA, by Program, FY2011-FY2022,
in CRS Report R46991, Economic Development Administration: An Overview of Programs and Appropriations
(FY2011-FY2022), by Julie M. Lawhorn.
26 Daniel Gross and Bhaven Sampat, “America, Jump-Started: World War II R&D and the Takeoff of the U.S.
Innovation System,” NBER Working Papers, No. 27375, National Bureau of Economic Research, Inc., 2020.
27 Sintia Radu, “The U.S. Is (Again) Among the World’s Top Innovators,” U.S. News and World Report, August 8,
2019. See also Robert Hassink, “Advancing Place-Based Regional Innovation Policies” (2019); F. Hu, “Study on the
Roles and Responsibilities of Government in the Regional Innovation System,” in Frontiers in Enterprise Integration,
(CRC Press, 2008), pp. 381-384, https://www.taylorfrancis.com/chapters/edit/10.1201/9781003061090-58/study-roles-
responsibilities-government-regional-innovation-system-hu; and Karen G. Mills, Elisabeth B. Reynolds, and Andrew
Reamer, Clusters and Competitiveness: A New Federal Role for Stimulating Regional Economies, The Brookings
Institution, April 2008, https://www.brookings.edu/wp-content/uploads/2016/07/Clusters-Brief.pdf.
28 Amy Liu et al., “Making Local Economies Prosperous and Resilient: The Case for a Modern Economic Development
Administration,” The Brookings Institution, June 27, 2022, https://www.brookings.edu/research/making-local-
economies-prosperous-and-resilient-the-case-for-a-modern-economic-development-administration/.
29 National League of Cities, “Place-Based Policies for America's Innovation Economy,” 2019.
30 See, for example, U.S. Congress, House Committee on Science, Space, and Technology, Regional Innovation Act of
2021, 117th Cong., 2nd sess., February 28, 2022, H.Rept. 117-254 (Washington: GPO, 2022); and Bjørn T. Asheim,
Arne Isaksen, and Michael Trippl, Advanced Introduction to Regional Innovation Systems (Northampton, MA: Edward
Elgar Publishing, 2019), pp. 13-22.
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improving regional innovation administered by the National Science Foundation (NSF), the
Department of Commerce (DOC), the Department of Energy (DOE), and the Small Business
Administration (SBA). The selection of programs described below should be considered
illustrative and not comprehensive.
National Science Foundation (NSF)
Regional Innovation Engines Program
The CHIPS and Science Act (P.L. 117-167) authorized the creation of the Regional Innovation
Engines (RIE) program at NSF to support a broad range of activities intended to build regional
innovation systems. Activities under the program may include conducting use-inspired and
translational research; facilitating the adoption, development, and commercialization of research
results; developing and managing test beds and instrumentation necessary to advance key
technologies; training graduate students and conducting outreach to broaden participation in RIE
activities; and reimbursing the cost of commercialization activities.31
The entities eligible to receive RIE funding are accredited institutions of higher education with a
campus located in the United States and U.S.-based nonprofit and for-profit organizations. Other
entities, including federally funded research and development centers (FFRDCs), DOE national
laboratories, and state, local, and tribal governments, are eligible to receive funds through sub-
awards.32 To be eligible for funding, applicants must propose a partnership with one or more
institutions classified as a minority-serving institution, a historically black college or university, a
Tribal College or University, an Established Program to Stimulate Competitive Research
(EPSCoR) institution, a community college, or an emerging research institution.33
NSF is expected to administer the RIE program through two types of awards designed to fund
“regional coalitions of partnering organizations to establish NSF Engines that will catalyze
technology and science-based regional innovation ecosystems”:34
 Type-1 Awards. Type-1 Awards offer up to $1 million in total funding for up to
two years to enable awardees to lay the groundwork for establishing a new NSF
Engine, such as by defining the initial scope and developing strategic plans for an
NSF Engine in a given region and topic area.
 Type-2 Awards. Type-2 Awards offer up to $160 million in total funding for up
to 10 years to enable awardees to develop an NSF Engine across three distinct
phases: (1) creating firm partner and stakeholder commitments; (2) growing an
innovation system by expanding scientific, technical, education, and workforce
development; and (3) growing the innovation system as a national leader by
attracting increasing levels of economic activity and business creation. NSF
Engines are intended to emerge from the Type-2 Award funding period as a

31 P.L. 117-167, §10388.
32 National Science Foundation (NSF), “Regional Innovation Engines: Funding and Regions of Interest,”
https://beta.nsf.gov/funding/initiatives/regional-innovation-engines/funding-regions-interest.
33 P.L. 117-167, §10388(e)(2). An “emerging research institution” is defined as “an institution of higher education with
an established undergraduate or graduate program that has less than $50,000,000 in Federal research expenditures”
(§10002).
34 NSF, NSF Regional Innovation Engines Broad Agency Announcement, NSFBAA-ENGINES-2022-05-1,
https://sam.gov/opp/68c9f585eed7457a9c1c1fe5dd6ae9a2/view.
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mature innovation system that is well established and financially self-
sustaining.35
P.L. 117-167 did not authorize specific levels of appropriations for the RIE program; rather it
authorized a combined $6.5 billion for FY2023-FY2027 for two programs: the RIE and
Translation Accelerator programs.36 For FY2023, NSF requested $200 million to support up to 10
RIEs as part of the President’s annual budget request to Congress.37 REIs were not allocated a
specific funding amount in the Consolidated Appropriations Act, 2023 (P.L. 117-328), which
appropriated a total of $9.9 billion for NSF in FY2023,38 but the accompanying joint explanatory
statement expressed general support for the RIE program.39
Department of Commerce
Regional Technology and Innovation Hub Program
The CHIPS and Science Act (P.L. 117-167) established a new Regional Technology and
Innovation Hub Program at DOC.40 The law requires the designation of at least 20 geographically
distributed technology and innovation hubs in areas that are currently not leading technology
centers to support technology development, job creation, and the expansion of U.S. innovation
capacity. Congress directed two DOC agencies, the Economic Development Administration
(EDA) and the National Institute of Standards and Technology (NIST), to make hub designations
and awards using a competitive merit-review process and in a manner that ensures geographic
diversity and representation from communities of differing populations, among other
considerations. The program will administer two types of awards:
 Strategy development awards. Strategy development awards will support
planning, assessments, coordination, and other pre-development activities, as
well as the formation of workforce development strategies. Approximately 60
eligible consortia will receive strategy development awards.
 Strategy implementation awards. Strategy implementation awards are available
to regional technology and innovation hubs for workforce development; business
and entrepreneur development; technology development and maturation

35 Ibid.
36 P.L. 117-167, §10389(c) directs the NSF to establish Translation Accelerators to “further the research, development,
and commercialization of innovation in the key technology focus areas.” The Translation Accelerators are expected to
include two or more of the following entities: an institution of higher education, a for-profit company, a nonprofit
organization, a federal agency, or another entity determined by the NSF.
37 NSF, FY 2023 Budget Request to Congress, March 28, 2022, p. Cross-Theme Topics-25, https://www.nsf.gov/about/
budget/fy2023/pdf/fy2023budget.pdf.
38 P.L. 117-328.
39 Senator Patrick Leahy, “Explanatory Statement Submitted by Mr. Leahy, Chair of the Senate
Committee on Appropriations, Regarding H.R. 2617, Consolidated Appropriations Act, 2023,”
Senate, Congressional Record, vol. 168, no. 198 (December 20, 2022), p. S7950,
https://www.congress.gov/congressional-record/volume-168/issue-198/senate-section/article/
S7819-2.
40 See P.L. 117-167, Division B, Title VI—Miscellaneous Science and Technology Provisions, Subtitle C, Section
10621 for definitions of terms relevant to the Regional Technology and Innovation Hub program, including “eligible
consortium.”
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activities; and infrastructure-related activities. Regional technology and
innovation hubs do not have to receive a strategy development award to apply for
an implementation award.
The law does not list specific industry or technology focus areas for the hubs. However, P.L. 117-
167 outlines “considerations for the designation and award of implementation grants.” One of the
considerations indicates that, among other factors, the Secretary of Commerce shall consider
the potential of the eligible consortium to advance the research, development, deployment,
and domestic manufacturing of technologies in a key technology focus area, as described
in section 10387 of the Research and Development, Competition, and Innovation Act or
other technology or innovation sector critical to national security and economic
competitiveness.
The initial list of 10 key technology focus areas in Section 10387 (Division B, Title III, Subtitle
G) includes biotechnology, quantum information sciences, advanced materials science, and
advanced energy and industrial efficiency technologies, among others.41 Program applicants will
likely determine their technology focus area and hub activities based on their regional assets and
other factors.42
P.L. 117-167 authorized $10 billion to be appropriated over five years (FY2023-FY2027) for the
program.43 The Consolidated Appropriations Act, 2023 (P.L. 117-328) appropriated $500 million
for the Regional Technology and Innovation Hub Program.44
Recompete Pilot Program
The CHIPS and Science Act (P.L. 117-167) also established a new Recompete Pilot program at
the EDA to provide grants and cooperative agreements to persistently distressed areas in support
of long-term economic development and job creation.45 As an industry-neutral economic
development policy, the Recompete Pilot program does not explicitly require TBED or RIS, but
instead provides long-term, place-based assistance in amounts that will be larger than most

41 The full list of 10 initial key technology areas is artificial intelligence, machine learning, autonomy, and related
advances; high performance computing, semiconductors, and advanced computer hardware and software; quantum
information science and technology; robotics, automation, and advanced manufacturing; natural and anthropogenic
disaster prevention or mitigation; advanced communications technology and immersive technology; biotechnology,
medical technology, genomics, and synthetic biology; data storage, data management, distributed ledger technologies,
and cybersecurity, including biometrics; advanced energy and industrial efficiency technologies, such as batteries and
advanced nuclear technologies; and advanced materials science, including composites 2D materials, other next-
generation materials, and related manufacturing technologies.
42 As of March 2023, the DOC had not released a request for proposals or notice of funding opportunity for the
Regional Technology and Innovation Hub Program. However, in February 2023, the EDA requested stakeholder input
to inform future funding guidance. See EDA, “Request for Information on Implementation of the Regional Technology
and Innovation Hub Program,” 88 Federal Register 9427, February 14, 2023, https://www.govinfo.gov/content/pkg/
FR-2023-02-14/pdf/2023-03022.pdf.
43 P.L. 117-167 directs the Secretary of Commerce to provide $50 million for strategy development awards for
FY2023-FY2027; $2.950 billion for strategy implementation awards for FY2023-FY2024; and $7 billion for FY2025-
FY2027.
44 The Consolidated Appropriations Act, 2023 (P.L. 117-328) appropriated $41 million in regular appropriations in
Division B and $459 million in supplemental appropriations in Division N for the Regional Technology and Innovation
Hub Program.
45 Division B, Title VI—Miscellaneous Science and Technology Provisions, Subtitle C, Section 10621.
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existing EDA program awards.46 The minimum grant award amount will be $20 million. The
program will administer two types of awards:
 Strategy development awards. Strategy development awards will support
planning and other pre-development activities, such as the formulation of a
Recompete Plan. A Recompete Plan is a comprehensive economic development
plan that includes the proposed multiyear activities to be implemented, projected
costs, partner roles, and other information.
 Strategy implementation awards. Implementation funds may be used for
activities that are consistent with an applicant’s approved Recompete Plan in
order to support workforce development, business and entrepreneur development,
infrastructure (or other site development programs), and planning and technical
assistance activities. Implementation award recipients are not required to have
previously received a strategy development award.
The CHIPS and Science Act (P.L. 117-167, Section 10621) authorized $1 billion over five years
(FY2022-FY2026) for the program. The Consolidated Appropriations Act, 2023 (P.L. 117-328)
appropriated $200 million for the Recompete Pilot Program.47
Build to Scale (formerly “Regional Innovation Strategies”)48
The EDA administers the Build to Scale program (B2S)—formerly the Regional Innovation
Program (RIP) or the Regional Innovation Strategies (RIS) program—which was established in
Section 603 of the America COMPETES Reauthorization Act of 2010 (P.L. 111-358).49 The
program is designed to spur community and regional capacity-building by providing
commercialization assistance to entrepreneurs and supporting organizations that provide early-
stage investments to startups.50 B2S is composed of the Venture Challenge and the Capital
Challenge:
 Venture Challenge. The Venture Challenge funds entrepreneurship support
programs and other models to accelerate high-growth entrepreneurship activities.

46 As of March 2023, the DOC had not released a request for proposals or notice of funding opportunity for the
Recompete Pilot Program. However, in February 2023, the EDA requested stakeholder input to inform future funding
guidance. See EDA, “Request for Information on Implementation of the Distressed Area Recompete Pilot Program,” 88
Federal Register 11406, February 23, 2023, https://www.govinfo.gov/content/pkg/FR-2023-02-23/pdf/2023-03732.pdf.
47 The Consolidated Appropriations Act, 2023 (P.L. 117-328) appropriated $41 million in regular appropriations in
Division B and $159 million in supplemental appropriations in Division N for the Recompete Pilot program.
48 Build to Scale was called Regional Innovation Strategies (RIS) or Regional Innovations Program (RIP) in annual
appropriations bills from FY2014 to FY2021; EDA began administering RIS/RIP funding using the Build to Scale
program name in FY2020. OIE administered the first round of the RIS/RIP competitions in September 2014 (see EDA,
U.S. Department of Commerce, “Regional Innovation Program,” 82 Federal Register 3131-3137, January 11,
2017, https://www.federalregister.gov/documents/2017/01/11/2017-00116/regional-innovation-program). The RIS/RIP
included Science Parks Loan Guarantees in FY2014 (P.L. 113-76). In FY2015 (P.L. 113-235), the explanatory
statement indicated that the amount for regional innovation would include up to $5 million for planning grants for
science park infrastructure. See https://eda.gov/files/oie/ris/EDA-RIS-Full-Program-Evaluation.pdf for an evaluation of
the B2S/RIS program.
49 15 U.S.C. §3722.
50 EDA, “2019 Regional Innovation Strategies Program, Notice of Funding Opportunity,” January 31, 2019,
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312519.
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 Capital Challenge. The Capital Challenge provides operational support to help
organizations and regions expand access to risk capital.51
Figure 2 shows the locations of B2S grantees in FY2021 and FY2022. In FY2022 and FY2023,
Congress directed EDA to allocate $45 and $50 million, respectively, to the B2S program.52
Figure 2. Selected RIS Program Awards and Facilities, by Location

Sources: Map by CRS. Locations of EDA grant program awards are from https://www.eda.gov/news/press-
release/2022/09/02/president-biden-announce-21-winners-1-bil ion-american-rescue-plan and
https://www.eda.gov/funding/programs/build-to-scale. Locations of SBA RICs are based on information from
https://www.sba.gov/local-assistance/regional-innovation-clusters. Locations of DOE EPIC prize and funding
opportunity announcement (FOA) awards are from https://www.energy.gov/articles/department-energy-
announces-energy-incubator-prize-selections (DOE, October 2020 prize announcement);
https://www.energy.gov/articles/doe-awards-95-mil ion-support-clean-energy-innovation-and-commercialization-
across-america (DOE, June 2021 FOA announcement); and https://www.energy.gov/technologytransitions/
articles/us-department-energy-awards-13-mil ion-incubators-and-accelerators (DOE, December 2022 Phase 2
prize award announcement). Locations of the Manufacturing USA Institutes are from the list of centers at
https://www.manufacturingusa.com/institutes. Locations of the DOE national laboratories are based on the list at
https://www.energy.gov/doe-national-laboratories. Al locations are based on data as of January 26, 2023.

51 EDA, “NOFO—2020 Build to Scale Program—Concept Proposal,” EDA-HDQ-OIE-2020, https://www.grants.gov/
web/grants/view-opportunity.html?oppId=324375, and “NOFO—FY2020 STEM Talent Challege,” EDA-HDQ-OIE-
2020-2006617, https://www.grants.gov/web/grants/view-opportunity.html?oppId=328794.
52 CRS Report R46991, Economic Development Administration: An Overview of Programs and Appropriations
(FY2011-FY2022), by Julie M. Lawhorn, provides a summary of EDA appropriations by program (see “Table B-2.
Funding for EDA, by Program, FY2011-FY2022”).
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Notes: Map reflects location of program awardees for grant, cooperative agreement, and prize award programs
and the locations of the DOE national laboratories and Manufacturing USA Institutes. Markers indicate the
primary grant recipient location. Some grant awardees may represent multi-location projects or projects that
impact a state-wide or broader geographic region.
Economic Recovery Funding for Innovation Initiatives53
As a part of the federal disaster response and recovery assistance in FY2020 and FY2021,
Congress provided supplemental appropriations to the EDA Economic Adjustment
Assistance (EAA) program for COVID-19 pandemic response efforts. The EDA allocated some
of the supplemental appropriations to the RIS-related initiatives described below.
 The Coronavirus Aid, Relief, and Economic Security (CARES) Act (P.L. 116-
136), enacted March 27, 2020, provided $1.5 billion to the EDA for economic
adjustment assistance in response to the COVID-19 pandemic. In October 2020,
the EDA allocated $25 million to the Scaling Pandemic Resilience through
Innovation and Technology (SPRINT) Challenge grants to help regions address
the economic, health, and safety risks caused by the coronavirus pandemic
through entrepreneurship and innovation activities.54
 The American Rescue Plan (ARP) Act (P.L. 117-2), enacted March 11, 2021,
provided $3 billion to the EDA for economic adjustment assistance in response to
the COVID-19 pandemic. In July 2021, the EDA allocated $1 billion of this
supplemental funding for economic recovery activities to the Build Back Better
Regional Challenge (BBBRC), a new grant initiative to support new or existing
regional industry clusters.55 In September 2022, EDA announced 21 BBBRC
awards (see Figure 2).56 The EDA also allocated $500 million of ARP Act
funding to the Good Jobs Challenge to enhance local efforts to develop and
strengthen regional workforce training systems and sector-based partnerships, but
did not require grant recipients to focus on innovation or technology sectors.57
Manufacturing USA
Through the Revitalize American Manufacturing and Innovation Act, as amended, Congress
directed the Secretary of Commerce, operating through NIST, to establish a Manufacturing USA
program.58 Manufacturing USA is a network of institutes focused on facilitating the development
and commercialization of emerging manufacturing technologies. The network currently consists
of 16 institutes sponsored by DOC, the Department of Defense (DOD), and DOE and co-funded

53 For more information, see CRS Insight IN11402, The Economic Development Administration’s Economic Recovery
Assistance for COVID-19 Impacted Communities, and CRS Insight IN11712, The Economic Development
Administration’s American Rescue Plan (ARP) Act Grant Programs.
54 For more information and a list of grant recipients, see EDA, “SPRINT Challenge,” https://eda.gov/oie/sprint/.
55 For more information about the EDA’s allocation of supplemental appropriations approved in the American Rescue
Plan Act (P.L. 117-2), see CRS Insight IN11712, The Economic Development Administration’s American Rescue Plan
(ARP) Act Grant Programs. For information about EDA’s regional innovation programs and activities, see EDA,
“About OIE,” https://eda.gov/oie/.
56 EDA, “President Biden to Announce 21 Winners of $1 Billion American Rescue Plan Regional Challenge,”
September 2, 2022, https://www.eda.gov/news/press-release/2022/09/02/president-biden-announce-21-winners-1-
billion-american-rescue-plan.
57 For a summary of EDA’s Build Back Better Regional Challenge and Good Jobs Challenge grant awards, see
https://eda.gov/arpa/.
58 15 U.S.C. §278s; for more information on Manufacturing USA, see CRS Report R46703, Manufacturing USA:
Advanced Manufacturing Institutes and Network.
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with private sector partners (Figure 2). Manufacturing USA institutes (also called Manufacturing
Institutes) are intended to
 improve the competitiveness of United States manufacturing and increase the
production of goods manufactured predominantly within the United States;
 facilitate the transition of innovative technologies into scalable, cost-
effective, and high-performing manufacturing capabilities;
 accelerate the development of an advanced manufacturing workforce; and
 contribute to the development of regional innovation initiatives across the
United States.
Congress provided the Manufacturing USA program with $37 million in FY2023. Such funds are
for a new NIST-funded Manufacturing USA institute, to support the existing NIST-funded
Manufacturing USA institute, and for overseeing and carrying out the Manufacturing USA
program through the Manufacturing USA National Program Office. Manufacturing USA
institutes sponsored by DOE and DOD are funded through appropriations associated with those
agencies.
Department of Energy Programs
Energy Program for Innovation Clusters (EPIC) Program59
The DOE Office of Technology Transitions (OTT) administers the Energy Program for
Innovation Clusters (EPIC), which funds regional incubators and accelerators that support
energy-related technology innovation clusters, entrepreneurs, and start-ups. Figure 2 includes the
locations of the following EPIC awards:
 In October 2020, DOE awarded 20 prizes of $50,000 each to incubators and
accelerators focused on developing energy-related regional innovation clusters.60
 In June 2021, DOE awarded $9.5 million in cooperative agreements to 10
incubators and accelerators to facilitate energy hardware development.61
 In December 2022, DOE awarded $1.3 million in prizes to incubators and
accelerators to develop regional partnerships that facilitate energy technology
start-ups and related efforts.62

59 For more information on the Energy Program for Innovation Clusters (EPIC), see https://www.energy.gov/
technologytransitions/energy-program-innovation-clusters.
60 Department of Energy (DOE), “Department of Energy Announces Energy Incubator Prize Selections,”
https://www.energy.gov/articles/department-energy-announces-energy-incubator-prize-selections.
61 DOE, “DOE Awards $9.5 Million to Support Clean Energy Innovation and Commercialization Across America,”
June 4, 2021, https://www.energy.gov/articles/doe-awards-95-million-support-clean-energy-innovation-and-
commercialization-across-america.
62 DOE, “U.S. Department of Energy Awards $1.3 Million to Incubators and Accelerators in Support of Place-Based
Energy Innovation,” December 6, 2022, https://www.energy.gov/technologytransitions/articles/us-department-energy-
awards-13-million-incubators-and-accelerators.
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Congress directed DOE to allocate $5 million for the EPIC program for each of FY2020 through
FY2023.63
Regional Clean Energy Innovation Program64
The CHIPS and Science Act (P.L. 117-167) established the Regional Clean Energy Innovation
program to advance the innovation of clean energy technologies and improve the competitiveness
of U.S. firms in this sector. Subject to the availability of appropriations, the program will connect
state and local economic development organizations and universities with other stakeholders and
support clean energy innovation activities, such as:65
 facilitating the commercial application of clean energy products, processes, and
services, including through research, development, demonstration, or technology
transfer;
 improving stakeholder involvement;
 assessing different incentive mechanisms for clean energy development and
commercial applications;
 establishing and updating roadmaps;
 planning; and
 hosting conferences and events.
The Secretary of Energy is directed to consider geographic diversity, including rural, tribal, and
low-income communities as part of the selection process. P.L. 117-167 authorized $50 million for
each of FY2023 through FY2027 for the program. Congress, however, has yet to appropriate
funding for the program.

63 See explanatory statements accompanying annual appropriations laws for each of FY2020
through FY2023: Representative Nita Lowey, “Explanatory Statement Submitted by Mrs. Lowey,
Chairwoman of the House Committee on Appropriations Regarding H.R. 1865, Further
Consolidated Appropriations Act, 2020,” Congressional Record, vol. 165, No. 204-Book III
(December 17, 2019), p. H11248, https://www.congress.gov/116/crec/2019/12/17/CREC-2019-
12-17-pt3-PgH11061.pdf; Representative Nita Lowey, “Explanatory Statement Submitted by
Mrs. Lowey, Chairwoman of the House Committee on Appropriations Regarding H.R. 133,
Consolidated Appropriations Act, 2021,” Congressional Record, vol. 166, no. 218-Book
IV(December 21, 2020), p. H8375, https://www.congress.gov/116/crec/2020/12/21/166/218/
CREC-2020-12-21-pt4-PgH8311.pdf; Representative Rosa DeLauro, “Explanatory Statement
Submitted by Ms. Delauro, Chair of the House Committee On Appropriations, Regarding the
House Amendment to the Senate Amendment to H.R. 2471, Consolidated Appropriations Act,
2022,” House, Congressional Record, vol. 168, no. 42, (March 9, 2022), p. H2254,
https://www.congress.gov/117/crec/2022/03/09/168/42/CREC-2022-03-09-bk3.pdf; and Senator
Patrick Leahy, “Explanatory Statement Submitted by Mr. Leahy, Chair of the Senate Committee
on Appropriations, Regarding H.R. 2617, Consolidated Appropriations Act, 2023,” Senate,
Congressional Record, vol. 168, no. 198, (December 20, 2022), p. S8364,
https://www.congress.gov/congressional-record/volume-168/issue-198/senate-section/article/
S7819-2.
64 Division B, Title VI—Miscellaneous Science and Technology Provisions, Subtitle C, 2.
65 U.S. Congress, House Committee on Science, Space, and Technology, Regional Innovation Act of 2021, 117th Cong.,
2nd sess., February 28, 2022, H.Rept. 117-254 (Washington: GPO, 2022).
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Additional DOE Hub Programs for Technology Commercialization
The Infrastructure Investment and Jobs Act (IIJA, P.L. 117-58) authorized several new DOE
programs designed to advance the commercialization of specific types of energy or climate-
related technologies. Specifically, P.L. 117-58 authorized the Regional Clean Direct Air Capture66
Hubs and the Regional Clean Hydrogen Hubs67 programs to support direct air capture and
hydrogen demonstration projects. The IIJA directed the Secretary to prioritize awards for both
hub programs that “are likely to create opportunities for skilled training and long-term
employment to the greatest number of residents of the region.”68 The IIJA further directed the
Secretary of Energy to locate two Regional Clean Direct Air Capture Hubs in “economically
distressed communities” with “high levels of coal, oil, or natural gas resources.”69 The IIJA also
further directed the Secretary to select Regional Clean Hydrogen Hubs according to criteria in the
IIJA for feedstock diversity, end-use diversity, geographic diversity, hubs in natural gas-producing
regions, and additional criteria as needed in the Secretary’s judgment.70 The IIJA appropriated
$3.5 billion for the Regional Clean Direct Air Capture Hubs program (for the FY2022 through
FY2026 period) and appropriated $8 billion for the Regional Clean Hydrogen Hubs program (for
the FY2022 through FY2026 period).71
Small Business Administration
Regional Innovation Clusters Program
The Small Business Administration’s (SBA’s) Office of Entrepreneurial Development has
operated the Regional Innovation Cluster (RIC) program since FY2010.72 According to the SBA,
RICs are “on-the-ground collaborations between business, research, education, financing, and
government institutions that work to develop and grow a particular industry or related set of
industries in a geographic region.”73 RICs serve as networking hubs to help high-growth small
businesses connect with other small and large businesses, as well as with specialized suppliers,
academic institutions, service providers, and economic organizations in a geographic area. The
clusters help match those small businesses with technical assistance providers, development and
financing opportunities, and mentoring, among other activities.74 RICs are typically centered on

66 See P.L. 117-58, Division D, Title III, Section 40308. For more information, see CRS Report R47034, Energy and
Minerals Provisions in the Infrastructure Investment and Jobs Act (P.L. 117-58), coordinated by Brent D. Yacobucci.
For more information about DOE’s carbon capture and related programs, see CRS In Focus IF11861, DOE’s Carbon
Capture and Storage (CCS) and Carbon Removal Programs, by Ashley J. Lawson.
67 See P.L. 117-58, Division D, Title III, Section 40314. For more information about DOE’s hydrogen hubs, see CRS
Report R47289, Hydrogen Hubs and Demonstrating the Hydrogen Energy Value Chain, by Martin C. Offutt, and CRS
In Focus IF12163, Department of Energy Funding for Hydrogen and Fuel Cell Technology Programs FY2022, by
Martin C. Offutt.
68 42 U.S.C. §16161a(3)(E) and §16298d.
69 P.L. 117-58, Division D, Title III, Section 40308.
70 42 U.S.C. §16161a(3).
71 P.L. 117-58, Division J, Title III.
72 Congress has appropriated funding for the Regional Innovation Clusters Initiative since FY2010. For more
information on historical funding levels see Table 17 of CRS Report R43846, Small Business Administration (SBA)
Funding: Overview and Recent Trends, by Robert Jay Dilger, R. Corinne Blackford, and Anthony A. Cilluffo.
73 U.S. Small Business Administration (SBA), FY 2023 Congressional Budget Justification FY 2021 Annual
Performance Report, March 28, 2022, p. 87, https://www.sba.gov/sites/default/files/2022-04/
FY%202023%20SBA%20Congressional%20Budget%20Justification-508-2022-0413%20updated.pdf.
74 SBA, Regional Innovation Cluster Initiative Services—2018 Performance-Based Statement of Work, 2018,
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particular fields; including bioscience and health care, agriculture, and autonomous and
unmanned systems.75 Twenty-three clusters have participated in the program, and as of November
2022, the SBA supported 14 clusters (see Figure 2).76 In FY2020, the most recent year for which
data are available, 1,220 small businesses participated in a RIC.77 Congress directed $10 million
to the RIC program in FY2023.78
Additional Programs and Support for Regional Innovation Systems
Other federal programs that support innovation and R&D may not have regional economic
development as a core program objective even though they may contribute to or support core
stakeholders in a regional innovation system. Some such programs or activities may be place-
based in that the distribution of funding is contingent upon a location. For example:
 The Established Program to Stimulate Competitive Research (EPSCoR)—
originally named the Experimental Program to Stimulate Competitive
Research—was established at NSF in 1978 to address congressional concerns
about an “undue concentration” of federal R&D funding in certain states. The
program is designed to help institutions in eligible states build infrastructure,
research capabilities, and training and human resource capacities to enable them
to compete more successfully for open federal R&D funding awards. In addition
to NSF, agencies with active EPSCoR programs include DOE, the National
Aeronautics and Space Administration, DOD, the U.S. Department of
Agriculture, and the National Institutes of Health (whose program is called the
Institutional Development Award [IDeA] program).79
 Federal laboratories and other federal R&D assets are located across the nation.
These facilities have the potential to serve as anchors for regional innovation.
Some such entities, including DOE’s national laboratories, often actively engage
in place-based innovation. For example, in 2020, Argonne National Laboratory
established a collaboration space in Chicago, IL with the “mission to drive
inclusive innovation that will help advance economic and societal impacts for
underserved and under-represented communities.”80 In January 2023, DOE
announced a request for information for strategies to apply the resources
associated with DOE national laboratories, plants, and sites to further support
economic growth and place-based innovation activities.81 Figure 2 shows the
locations of the DOE national laboratories.

https://sam.gov/api/prod/opps/v3/opportunities/resources/files/49614056be72fe01d0c5d49c3e0a2ab3/download?&
status=archived&token=.
75 SBA, “Regional Innovation Clusters,” https://www.sba.gov/local-assistance/regional-innovation-clusters.
76 SBA, “Data Collection Available for Public Comments,” 87 Federal Register 8906, February 16, 2022; and SBA,
“Regional Innovation Clusters,” https://www.sba.gov/local-assistance/regional-innovation-clusters.
77 SBA, FY 2022 Congressional Justification FY 2020 Annual Performance Report, June 11, 2021, p. 89,
https://www.sba.gov/sites/default/files/2021-06/FY2022_SBA_Congressional_Justification-508_0.pdf.
78 U.S. Congress, House Committee on Appropriations, Subcommittee on Financial Services and General Government,
Financial Services and General Government Appropriations Bill, 2023, report to accompany H.R. 8254, 117th Cong.,
2nd sess., June 28, 2022, H.Rept. 117-393 (Washington: GPO, 2022), p. 108.
79 For more information on EPSCoR, see CRS Report R44689, Established Program to Stimulate Competitive
Research (EPSCoR): Background and Selected Issues, by Laurie A. Harris.
80 Argonne National Laboratory, “Argonne in Chicago,” https://www.anl.gov/chicago.
81 DOE, “Activation Energy: DOE’s National Laboratories as Catalysts of Regional Innovation,” 88 Federal Register
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 The DOC Hollings Manufacturing Extension Partnership (MEP) Program
provides place-based, business technical assistance to small and medium-sized
manufacturers (SMMs, manufacturing firms with 500 or fewer employees) to
improve production processes, upgrade technological capabilities, and facilitate
product innovation. The MEP Program is a network of state and regional
centers—located in all 50 states and Puerto Rico—established by Congress in
1988 through the Omnibus Trade and Competitiveness Act (P.L. 100-418).82
Funding for the MEP centers is provided on a cost-shared basis between the
federal government and nonfederal sources, including state and local
governments, and fees charged to SMMs for center services. Congress
appropriated $75 million to the MEP program in FY2023 (P.L. 117-328).
In addition, policies designed to address the science and engineering workforce and STEM
education are generally considered core components of—and complementary to—the
development of RIS.83 Technology firms that seek STEM workers may be incentivized to locate
in areas with an experienced, existing workforce and K-12 schools with a strong STEM
curriculum. Over the years, Congress has authorized various programs to address STEM
workforce and training needs. For example, the CHIPS and Science Act (P.L. 117-167) provided
$200 million in funding for a Creating Helpful Incentives to Produce Semiconductors (CHIPS)
for America Workforce and Education Fund to support microelectronics workforce development
activities.
Considerations for Congress
The growth in federal attention to and support for regional innovation, including the
establishment of several new RIS programs in the CHIPS and Science Act (P.L. 117-167), raises a
number of implementation and execution issues for Congress.
Scale, Scope, and Duration of Federal Investments
Federal regional innovation programs vary in scale and in the scope with regard to activities and
sectors supported. For example, some programs, such as DOE’s Energy Program for Innovation
Clusters program and SBA’s Regional Innovation Clusters Initiative, offer relatively small,
targeted awards (from $50,000 to $300,000) to incubators, accelerators, and other organizations
that seek to foster industry clusters through the provision of mentoring, networking, and other
support services to start-ups and entrepreneurs. The newly created Regional Technology and
Innovation Hub program at EDA is authorized to provide larger awards, up to $150 million in a
single strategy implementation award, that can be used for a broader range of activities, including
workforce development, business and entrepreneur development, technology development and
maturation, and infrastructure projects. The duration of the period of performance for the federal
investments also varies, with some programs providing one-time funding over two to five years
and others providing subsequent awards that extend the duration of federal investment closer to a
decade. Most programs have a legislatively set limit on the duration of federal investment, but in

5323, January 27, 2023, https://www.federalregister.gov/documents/2023/01/27/2023-01440/activation-energy-does-
national-laboratories-as-catalysts-of-regional-innovation.
82 For more information on the Hollings Manufacturing Extension Partnership (MEP) program, see CRS Report
R44308, The Hollings Manufacturing Extension Partnership Program, by John F. Sargent Jr.
83 OECD, Reviews of Regional Innovation, Regions and Innovation Policy, 2011, pp. 45-48.
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the case of EDA’s Regional Technology and Innovation Hub program, Congress provided the
Secretary of Commerce with the discretion to determine the duration of any subsequent award.
Given the diversity of RIS investments, Congress may consider the most effective way to provide
federal funds in support of regional innovation efforts. Since regional economic development is
often a long-term process, Congress may wish to consider whether the funding periods of relevant
programs are adequate to achieve stated RIS goals.
Congress may also consider connecting the duration and scale of federal support to the level of
maturity of a particular RIS. For example, an emerging RIS might receive more funding over a
longer period of time than a mature regional innovation system seeking to reinvigorate or adapt
its specialization (i.e., cluster or focus area). Additionally, Congress may consider how best to
sustain regional innovation efforts after federal funding ceases.
Coordination of Federal Regional Innovation Investments
Interagency Coordination
Regional innovation programs and related activities are supported by multiple agencies, including
EDA, SBA, NIST, DOE, and NSF, among others. Figure 2 shows the location of select regional
innovation awards, in addition to the DOE national laboratories and Manufacturing USA
institutes. As shown in Figure 2, awards from different agencies are often made in the same
region or location. Insufficient interagency coordination could impact the efficiency and
effectiveness of federal support for regional innovation efforts. For example, a lack of
coordination could result in duplicative efforts, in addition to missed opportunities to leverage or
complement supported activities.
Congress required interagency coordination for some of the regional innovation programs created
in the CHIPS and Science Act (P.L. 117-167). Specifically, P.L. 117-167 requires the Secretary of
Commerce, prior to designating an area as a regional technology and innovation hub or making
an award for the implementation of a hub’s strategy, to coordinate with other federal agencies
whose missions contribute to the goals of the hub. P.L. 117-167 also requires the Secretary of
Commerce to consult with NSF “for the purpose of ensuring that the regional technology and
innovation hubs are aligned with relevant science, technology, and engineering expertise.”
Similarly, the law requires the NSF Director to ensure that “the focus areas of the Regional
Innovation Engines do not substantially and unnecessarily duplicate the efforts of any other
Regional Innovation Engine or any other similar effort at another federal agency.” It also
authorized each of NSF’s Regional Innovation Engines to “collaborate and participate in, as
appropriate, the activities of any regional technology hub.”
RIS Program Alignment
In addition to more general considerations around program coordination, Congress and others
have expressed a specific interest in how the NSF Regional Innovation Engines and EDA
Regional Technology and Innovation Hub programs align. For example, the joint explanatory
statement for the Consolidated Appropriations Act, 2023 (P.L. 117-328) stated “in implementing
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the NSF Engines, the Foundation is encouraged to coordinate with the EDA Regional Technology
Hubs program.”84
In a presentation before the President’s Council of Advisors on Science and Technology, Dr.
Erwin Gianchandani, Assistant Director for Technology, Innovation, and Partnerships at NSF,
described how the NSF Regional Innovation Engines and the DOC Regional Technology and
Innovation Hub programs fit together (Figure 3). He indicated that:
The Regional Innovation Hubs [Engines] will start with fundamental research and add
innovation and translation ecosystems to broaden participation through the intentional
engagement of populations underrepresented in STEM. The Regional Technology Hubs
will build on a region’s current and future economic drivers, and their work on later-stage
technology development will scale capacity to deploy breakthrough technologies....
Together, the two programs will serve as the connective tissue for an innovation ecosystem
built on public-private partnerships.85
Figure 3. Comparison of NSF Regional Innovation Engines and EDA Regional
Technology and Innovation Hub Programs

Source: Presentation by Dr. Erwin Gianchandani, Assistant Director for Technology, Innovation, and
Partnerships, National Science Foundation, before the President’s Council of Advisors on Science and
Technology, September 21, 2022, https://www.whitehouse.gov/wp-content/uploads/2022/11/Gianchandani_TIP-
and-NSF-Engines-for-PCAST_Sept-2022.pdf.

84 Senator Patrick Leahy, “Explanatory Statement Submitted by Mr. Leahy, Chair of the Senate
Committee on Appropriations, Regarding H.R. 2617, Consolidated Appropriations Act, 2023,”
Senate, Congressional Record, vol. 168, no. 198 (December 20, 2022), p. S7950,
https://www.congress.gov/congressional-record/volume-168/issue-198/senate-section/article/
S7819-2.
85 Public Meeting of the President’s Council of Advisors on Science and Technology, “Meeting Minutes,” September
21, 2022, https://www.whitehouse.gov/wp-content/uploads/2022/11/Meeting-Minutes_PCAST-Public-Meeting_9-21-
2022_Final.pdf.
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While Congress requires some level of coordination and consultation between the Department of
Commerce (i.e., EDA and NIST) and NSF for the Regional Technology and Innovation Hub and
Regional Innovation Engines programs, DOC and NSF may also coordinate with other programs
that play a role in regional innovation (e.g., the EDA Build to Scale program and the SBA
Regional Innovation Clusters Initiative).
Federal Interagency Working Group Considerations
P.L. 117-167 requires the Director of the Office of Science and Technology Policy to establish an
interagency working group through the National Science and Technology Council that may
facilitate additional coordination of federal regional innovation investments. The interagency
working group is directed to “seek to ensure that the activities of different federal agencies
enhance and complement, but, as appropriate, do not duplicate, efforts being carried out by
another federal agency.” A subset of regional innovation programs—NSF’s Regional Innovation
Engines program, NIST’s Manufacturing USA and Manufacturing Extension Partnership
programs, and EDA’s Regional Technology and Innovation Hub program—are mentioned as part
of the activities federal agencies are directed to coordinate; however, the coordination focus is on
activities in the key technology areas listed in P.L. 117-167. Key technology area activities may
or may not be place-based. In addition, programs created outside of P.L. 117-167, in general, are
not required to support efforts that focus on the key technology areas. Furthermore, those that are
required to consider if a regional innovation effort is focused on a key technology area may do so
to a greater or lesser extent.
As such, the interagency working group required by P.L. 117-167 may be insufficient in
providing government-wide coordination of all federal investments in regional innovation.
Congress may consider modifying the responsibilities of the interagency working group to ensure
broader coordination of federal regional innovation efforts or it could consider tasking another
entity with that responsibility. For example, in 2010, EDA’s Office of Innovation and
Entrepreneurship (OIE) was established to coordinate activities related to innovation,
commercialization, and entrepreneurship between the Department of Commerce, other federal
agencies, and state and local governments.86 OIE’s roles and responsibilities could be expanded to
include broader, more comprehensive coordination of federal regional innovation activities. OIE
could also be tasked with facilitating intergovernmental coordination and information sharing to
help ensure that federal resources are aligned with, leveraged by, and meet the needs of regional
efforts supported by state, local, and tribal governments (see additional discussion below).
EDA Roles and Resources
Congress may seek to review EDA’s role in interagency coordination and technical assistance
activities that may facilitate the implementation of new RIS programs. The America COMPETES
Reauthorization Act of 2010 (P.L. 111-358) identified a leadership role for EDA in certain
interagency coordination roles (i.e., through EDA’s OIE and National Advisory Council on
Innovation and Entrepreneurship (NACIE) activities).87 Since then, as summarized above,

86 See EDA, “About OIE,” https://eda.gov/oie/. OIE was established by the America COMPETES Reauthorization Act
of 2010 (P.L. 111-358). The National Advisory Council on Innovation and Entrepreneurship (NACIE) was established
in 2009 by Section 25(c) of the Stevenson-Wydler Technology Innovation Act of 1980, as amended (15
U.S.C. §3720(c)).
87 Ibid. NACIE was established by the same law, P.L. 111-358, to “provide advice to the Secretary” of Commerce
about the implementation of the OIE. See 15 U.S.C. §3720.
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Congress has authorized several new RIS programs for administration by EDA as well as new
programs to be administered by agencies outside of the Department of Commerce (e.g., DOE,
NSF). However, a House hearing report in June 2021 noted that it is unclear how other federal
regional innovation programs should be coordinated to facilitate regional innovation economies.88
Additionally, some analysts have proposed expanding EDA’s activities to include additional
training and resources for state, regional, and local stakeholders. Specifically, some suggest that
EDA may expand its role in disseminating economic development policy insight and analysis.89
Congress may be interested in reviewing options to increase EDA’s capacity to coordinate RIS
development, including its technical expertise and staffing levels. Congress and outside groups
have remarked on EDA’s expertise in regional development, and that innovation technology
expertise is “spread across many different agencies and programs” at the DOC, including NIST
and NSF. Among other options, Congress may continue to encourage the agency to consider
detailees or intergovernmental exchange programs.90
Data for Decisionmaking and Capacity-Building
Regional innovation systems are often based on industry clusters or a geographic concentration of
interconnected companies and institutions in a specific field. Some analysts believe that such
clusters cannot be created from scratch and must relate “to some historical industry strength in the
region.”91 Determining whether a cluster exists in a region or what cluster a region should focus
its efforts on can be a complex process. Factors for cluster selection include (1) growth potential
and stage of development; (2) specialization; (3) intensity of relationships within the cluster; and
(4) the structure and complexity of the cluster, among others.92 RIS experts observe that
incorporating data into decisionmaking processes may improve the identification and
prioritization of clusters. Such data analysis may also help determine what strategic interventions,
cluster-based or not, a region should implement to increase regional innovation.
In 2016, NACIE recommended that the DOC create “an online, dynamic web resource that
catalogues and curates the growing number of indices and tools that seek to measure
innovation.”93 According to NACIE,
Such a resource would not provide evaluative commentary on individual measures or
indices; instead, as a curated collection, the resource provides descriptive information, such
as authors, major funding sources, primary objectives of measures and indices, and data

88 U.S. Congress, House Committee on Science, Space, and Technology, Subcommittee on Research and Technology,
Hearing Charter—Regional Innovation Act of 2021, 117th Cong., 2nd sess., June 9, 2021.
89 Amy Liu et al., “Making Local Economies Prosperous and Resilient: The Case for a Modern Economic Development
Administration,” The Brookings Institution, June 27, 2022, https://www.brookings.edu/research/making-local-
economies-prosperous-and-resilient-the-case-for-a-modern-economic-development-administration/.
90 U.S. Congress, House Committee on Science, Space, and Technology, Regional Innovation Act of 2021, 117th Cong.,
2nd sess., February 28, 2022, H.Rept. 117-254 (Washington: GPO, 2022).
91 Bjørn T. Asheim, Arne Isaksen, and Michael Trippl, Advanced Introduction to Regional Innovation Systems
(Northampton, MA: Edward Elgar Publishing, 2019), p. 22; and Ryan Donahue, Joseph Parilla, and Brad McDearman,
Rethinking Cluster Initiatives, Brookings Institution, Washington, DC, July 2018, https://www.brookings.edu/wp-
content/uploads/2018/07/201807_Brookings-Metro_Rethinking-Clusters-Initiatives_Full-report-final.pdf.
92 Ibid.
93 NACIE, Encyclopedia of Innovation Measures Recommendation, July 12, 2016, p. 1, https://www.eda.gov/sites/
default/files/files/oie/nacie/meetings/20160712-Encyclopedia-of-Innovation-Measures-NACIE.pdf.
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sources. The system’s architecture, therefore, becomes highly searchable and enables
comparisons in multiple ways such as by state, by year, or by type of indicator.94
A collection of innovation measures could assist regions in examining their strengths and
weakness, in addition to assisting federal agencies in determining the most appropriate type of
funding and support to provide. Some research suggests that government effectiveness and
institutional quality at the local and regional level are enabling factors in the development and
implementation of regional innovation strategies.95 As such, a pre-condition for innovation may
involve the creation of programs and funding focused on building institutional capacity. Capacity-
building efforts could focus on research capacity. For example, NSF’s Enabling Partnerships to
Increase Innovation Capacity (EPIIC) program seeks to support institutions of higher education
with limited research capabilities (i.e., minority-serving institutions, predominantly undergraduate
institutions, and two-year institutions) so that such institutions can participate in NSF’s Regional
Innovation Engines program in the future.
Capacity-building efforts could also focus on the quality of local and regional governance. Given
the bottom-up nature of regional innovation, improving the ability of regional organizations and
local governments to formulate regional strategies, promote and coordinate the participation of
stakeholders, and monitor and evaluate implementation will likely be critical to the overall
success of federal regional innovation efforts.
RIS Governance Considerations
Congress may consider how federal agencies can best promote good governance at the local and
regional level for overall RIS sustainability, communication, and accountability purposes. For
example, NSF’s Regional Innovation Engines program requires that each Engine “be led by a
visionary full-time chief executive, who is the senior official in charge of managing the Engine
and is responsible for its overall success.”96 The program also requires each Engine to establish a
governance board that “provides, at a minimum, administrative oversight of the Engine’s
activities and is responsible for the Engine’s performance.”97 In another example, EDA’s BBBRC
program required applicants to designate a “regional economic competitiveness officer”
responsible for convening leaders, managing communications, serving as the central coordinator
of new and existing resources to the benefit of regional competitiveness, and other roles.98
While governance requirements may prove sufficient in ensuring regions have the necessary
institutional capacity, other guidance, such as increased technical assistance and the sharing of
best practices may be needed for regions that have limited experience in technology-based
economic development. In addition, a preliminary examination of EDA’s BBBRC program
indicated that regional leaders need help in developing data and tracking systems to implement
“more holistic, inclusive [innovation] indicator frameworks.”99

94 Ibid., pp. 1-2.
95 Andrés Rodríguez-Pose, Marco di Cataldo, and Alessandro Rainoldi, The Role of Government Institutions for Smart
Specialisation and Regional Development, European Commission, Joint Research Center, S3 Policy Brief Series, No.
04/2014, 2014, https://publications.jrc.ec.europa.eu/repository/handle/JRC88935.
96 NSF, Regional Innovation Engines Broad Agency Announcement, NSFBAA-ENGINES-2022-05-1, December 20,
2022.
97 Ibid.
98 EDA, FY 2021 American Rescue Plan Act Build Back, EDA-HDQ-ARPBBB-2021-2006976, July 22, 2021.
99 Joseph Parilla, Glencora Haskins, and Mark Muro, The Future of Place-Based Economic Policy: Early Insights from
the Build Back Better Regional Challenge, Brookings Institution, Washington, DC, November 2022, p. 33,
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Equity and Innovation
Some analysts view a shift towards expanded federal, place-based policies, including RIS, as an
approach that may advance U.S. competitiveness while also addressing concerns around
economic inclusion, regional disparities, and equity.100 Some scholars, policymakers, and
administrators have expressed interest in understanding the demography of America’s innovation
ecosystem and have expressed concerns that the barriers faced by certain socioeconomic, racial,
and gender-based groups hinders participation, which may negatively impact U.S. technological
competitiveness.101 Some studies suggest that the marginalization of certain groups within
society, in terms of who can access the “innovation ecosystem” (including advanced training and
education, R&D funding, and venture capital), has a dampening effect on innovation.102 When
significant numbers of potential innovators do not participate in the innovation process, their
unique perspectives and ideas may be lost.103 Additionally, some proponents of expanded federal
RIS policies consider the potential of additional investment in underserved communities as a
means of addressing geographic socioeconomic divergence. These views reflect concerns about
“lagging regions” and social division, among other concerns.104
In overseeing the implementation of RIS programs, Congress may wish to consider the insights
garnered from an analysis of a program with similar RIS-based goals: the EDA’s BBBRC. A
November 2022 Brookings Institution report analyzed the degree to which BBBRC finalists
successfully integrated congressionally mandated equity goals within their regional development
plans, among other things, concluding that while “the BBBRC’s top priority was equity,” grant
recipients “had mixed success embedding equity in strategies, governance, and metrics.”105
Analysts from Brookings also noted that the BBBRC’s accelerated application timeline, which
required participants to condense planning and coalition building into a matter of weeks, may

https://www.brookings.edu/wp-content/uploads/2022/11/EDA-BBBRC_final.pdf.
100 Amy Liu et al., “Making Local Economies Prosperous and Resilient: The Case for a Modern Economic
Development Administration,” The Brookings Institution, June 27, 2022, https://www.brookings.edu/research/making-
local-economies-prosperous-and-resilient-the-case-for-a-modern-economic-development-administration/.
101 Shobita Parthasarathy, “Innovation as a Force for Equity,” Issues in Science and Technology, vol. XXXVIII, no. 2
(Winter 2022); Jonathan Gruber and Simon Johnson, Jump-Starting America: How Breakthrough Science Can Revive
Economic Growth and the American Dream (New York: Public Affairs, 2019); Alexander Kersten and Gabrielle
Athanasia, Untapped Innovation? The Racial and Gender Divides That Hinder the U.S. Knowledge Economy, Center
for Strategic and International Studies, CSIS Briefs, May 2022, https://csis-website-prod.s3.amazonaws.com/s3fs-
public/publication/220525_Kersten_Untapped_Innovation.pdf?xSNyYflYj1TUlHfA_TJ7mdbu2TLxijpb; Lisa D.
Cook, Policies to Broaden Participation in the Innovation Process, The Hamilton Project, Brookings, Policy Proposal
2020-11, August 2020; Holly Fechner and Matthew S. Shapanka, “Closing Diversity Gaps in Innovation: Gender,
Race, and Income Disparities in Patenting and Commercialization of Inventions,” Technology and Innovation, vol. 19
(2018), pp. 727-734.
102 Lisa D. Cook, Policies to Broaden Participation in the Innovation Process, The Hamilton Project, Brookings,
Policy Proposal 2020-11, August 2020.
103 Holly Fechner and Matthew S. Shapanka, “Closing Diversity Gaps in Innovation: Gender, Race, and Income
Disparities in Patenting and Commercialization of Inventions,” Technology and Innovation, vol. 19 (2018), pp. 727-
734.
104 Robert D. Atkinson, Mark Muro, and Jacob Whiton, The Case for Growth Centers: How to Spread Tech Innovation
across America, The Brookings Institution and The Information Technology and Innovation Foundation, Washington,
DC, December 8, 2019, https://www.brookings.edu/research/growth-centers-how-to-spread-tech-innovation-across-
america/.
105 Joseph Parilla, Glencora Haskins, and Mark Muro, The Future of Place-Based Economic Policy: Early Insights
From the Build Back Better Regional Challenge, Brookings Metro, November 17, 2022, p. 29,
https://www.brookings.edu/research/the-future-of-place-based-economic-policy-early-insights-from-the-build-back-
better-regional-challenge/.
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have hampered the ability of recipients to develop comprehensive equity plans. The report’s
assessment of the specific ways BBBRC finalists failed to fully deliver on the program’s intended
equity goals may prove useful in overseeing the implementation of subsequent regional
innovation programs:
Equity strategies were weakest when they relied on boilerplate arguments about inclusion,
either by failing to develop initiatives targeted to their region’s historically excluded
populations or neglecting to articulate how equity-focused community organizations were
meaningfully integrated into each project’s planning, governance, and execution.106
Congress may wish to consider potential metrics to assess program design and efficacy in
addressing disparities in innovation. For instance, patenting rates within the United States
(specifically utility patenting rates, the largest component of patenting activity) demonstrate that
innovative activity is not currently distributed evenly throughout the country. Analyzing the
“geography of U.S. patenting,” the 2022 Science and Engineering Indicators report, published by
the National Science Board, found that areas of high patenting intensity in the United States
(measured by the patent owner’s location per 1,000 residents) are primarily concentrated along
the coasts, in Texas, and in parts of the Great Lakes and Rocky Mountains (see Figure 4).107 The
report also found that, in 2020, 41.6% of U.S. counties had zero patents granted to people
residing in that county.108 Since patents are widely recognized as an important measure of
innovation, monitoring the trends in U.S. patenting activity may assist policymakers in assessing
current sources of innovation and in identifying potential inequities that may limit future U.S.
technological and economic leadership.109 Congress may also wish to consider evaluating
whether investments in regional innovation programs increase patenting rates in targeted regions
or for minority- and women-owned businesses.

106 Ibid.
107 National Science Board, NSF, Invention, Knowledge Transfer, and Innovation. Science and Engineering Indicators
2022, NSB-2022-4, Alexandria, VA, p. 19, https://ncses.nsf.gov/pubs/nsb20224/.
108 Ibid., p. 20.
109 For more information on patents and innovation policy, see CRS Report R47267, Patents and Innovation Policy, by
Emily G. Blevins.
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Figure 4. U.S. Patent and Trademark Office (USPTO) Utility Patents Granted to U.S.
Owners per 1,000 Residents, by U.S. County: 2020

Source: National Science Board, National Science Foundation, Invention, Knowledge Transfer, and Innovation.
Science and Engineering Indicators 2022, NSB-2022-4, 2022, https://ncses.nsf.gov/pubs/nsb20224/; population data
from the U.S. Census Bureau accessed June 2021, https://www.census.gov/newsroom/press-releases/2021/2020-
vintage-population-estimates.html, cited in National Science Board, National Science Foundation, Invention,
Knowledge Transfer, and Innovation. Science and Engineering Indicators 2022, NSB-2022-4, 2022,
https://ncses.nsf.gov/pubs/nsb20224/.
Capital Access
The availability of private market capital is associated with increased levels of business starts,
income, and employment growth, and is an integral component of RIS. Venture capital is one of
several types of private market capital that may facilitate the formation of high-growth business
and may support funding needs for specific phases of innovation processes.110 However, barriers
to capital may limit innovation and hamper the eventual growth of firms and regional

110 Sampsa Samila and Olav Sorenson, “Venture Capital, Entrepreneurship, and Regional Economic Growth,” (July 6,
2009), available at SSRN, https://ssrn.com/abstract=1183576; Robert Fairlie, Alicia Robb, and David Robinson, “Black
and White: Access to Capital Among Minority-Owned Startups” (Stanford Institute for Economic Policy Research, 99
December 2016), https://doi.org/10.3386/w28154.
According to SBA’s “Venture Capital” video and transcript, venture capital (VC) is:
a type of equity financing that addresses the funding needs of entrepreneurial ventures which, for
reasons of size, assets, and stage of development, cannot seek capital from more traditional sources,
such as public markets and banks. Venture capital investments are generally made as cash in
exchange for shares and play an active role in the company invested in.
For more information, including a summary of advantages and disadvantages of VC, see https://learn.sba.gov/learning-
center-launch/learning-center-financing-your-business/venture-capital.
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economies.111 Private capital resources, and venture capital in particular, are not evenly
distributed across all regions of the United States and may not be available to all types and sizes
of firms. For instance, minority business enterprises face barriers in accessing private market
capital, particularly private equity and venture capital.112 Industry reports also document the
regional disparities in venture capital availability, which is generally concentrated in certain
metro regions.113
Congress has taken several actions to expand capital access programs. For example, Congress
continues to support SBA and Minority Business Development Agency (MBDA) programs
designed to expand access to credit for specific types of businesses and types of capital.
Considering recent congressional examinations of the barriers to certain types of private market
capital,114 and the expansion of RIS programs, Congress may be interested in reviewing how
existing or new capital access programs may be used to address regional innovation and capital
access disparities. Congress may be interested in reviewing options to create criteria to prioritize
SBA and MBDA capital access awards in regions participating in new or existing RIS
programs.115 In its oversight of the Regional Technology and Innovation Hubs and other
programs, Congress may also consider a review of lender and investment partner participation
data and how regional hubs coordinate with SBA- and MBDA-supported initiatives. In addition
to the matter of integrating capital access programs with new RIS programs, Congress may
continue to review federal options to support firm-level capital needs associated with specific
phases of technology development and innovation processes (e.g., loan guarantee programs,
grants for venture development organizations, capital for private sector venture funds).116

111 William R. Kerr and Ramana Nanda, “Financing Constraints and Entrepreneurship,” Handbook of Research on
Innovation and Entrepreneurship (Northampton, MA: Edward Elgar Publishing, 2011), among others.
112 Robert W. Fairlie, Alicia Robb, and David T. Robinson, “Black and White: Access to Capital Among Minority-
Owned Startups,” NBER Working Paper No. 28154 (November 2020), https://doi.org/10.3386/w28154; V. Hwang, S.
Desai, and R. Baird, “Access to Capital for Entrepreneurs: Removing Barriers,” Ewing Marion Kauffman Foundation:
Kansas City (2019); and Robert W. Fairlie, Alicia M. Robb, and David Hinson, “Disparities in Capital Access Between
Minority and Non-Minority-Owned Businesses,” Minority Business Development Agency (2010),
https://www.mbda.gov/sites/default/files/migrated/files-attachments/DisparitiesinCapitalAccessReport.pdf.
113 See, for example, the National Venture Capital Association (NVCA) 2022 Yearbook, an annual yearbook published
by a national VC industry association that describes aspects of the U.S. venture capital industry, among others. The
NVCA 2022 Yearbook noted that
California, Massachusetts, and New York continued their dominance for [venture capital] VC
activity; collectively, these three states accounted for 54% of total deal count and 73% of total
capital invested in 2021, with both metrics on par with 2020 figures.
See NCVA, NCVA 2022 Yearbook, https://nvca.org/wp-content/uploads/2022/03/NVCA-2022-Yearbook-Final.pdf.
114 During the 116th and 117th Congresses, the House Committees held hearings that noted capital access, workforce,
and education challenges and their impact on U.S. competitiveness as well as the overall innovation and
entrepreneurship ecosystems. See, for example, U.S. Congress, House Committee on the Judiciary, Subcommittee on
Courts, Intellectual Property, and the Internet, Lost Einsteins: Lack of Diversity in Patent Inventorship and the
Impact on America's Innovation Economy, 116th Cong., 1st sess., March 27, 2019; U.S. Congress, House Committee on
Small Business, Subcommittee on Innovation, Entrepreneurship, and Workforce Development, Enhancing Patent
Diversity for America’s Innovators, 116th Cong., 2nd sess., January 15, 2020; and U.S. Congress, House Committee on
Small Business, Subcommittee on Economic Growth, Tax, and Capital Access, Innovation as a Catalyst for New Jobs:
SBA’s Innovation Initiatives, 117th Cong., 1st sess., July 14, 2021; among others.
115 For an example of this perspective and other federal roles in expanding access to capital in the RIS context, see
Robert D. Atkinson, Mark Muro, and Jacob Whiton, The Case for Growth Centers: How to Spread Tech Innovation
Across America, The Brookings Institution and The Information Technology and Innovation Foundation, Washington,
DC, December 8, 2019, https://www.brookings.edu/research/growth-centers-how-to-spread-tech-innovation-across-
america/.
116 EDA defines a Venture Development Organization (VDO) as “a state or nonprofit entity that contributes to regional
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Startups and Small Business Considerations
Economic development practitioners generally consider the growth and eventual sale or
ownership transition of successful startups as beneficial to regional economies.117 Experts on
business startups note that there are many types of startups, but few are high-growth. Further,
startups have a high rate of failure and it is difficult to predict which startups may affect
productivity and/or employment growth.118
One method of supporting high-growth startups in RIS policies could be through size-neutral
criteria such as the business’s age or growth phase. For example, EDA’s Seed Fund Support
(SFS) program (part of its B2S/RIS program) provides funding for the creation or expansion of
seed funds and entrepreneurial support organizations that focus on “innovation-based startups
with a potential for high growth and job creation.”119 The SBA’s Growth Accelerator Fund
Competition (GAFC) funds business accelerators that provide technical support to small business
startups. The GAFC program also targets accelerators that support businesses and/or geographies
that traditionally face barriers in obtaining R&D funds and investment capital: businesses owned
or led by women, minorities, and veterans, or businesses located in rural areas.120
In addition to startups, existing small businesses may support the development of RIS. Congress
has long supported small businesses through various policies such as contracting preferences and
technical assistance programs that prioritize small businesses.121 Congress may consider whether
and how to customize RIS policies to facilitate the growth and success of small businesses. For
example, Congress could consider policies that encourage small business development in regional
initiatives based on certain characteristics, such as the business’s location, the background of its
owner(s), or businesses in specific industries. Congress could consider establishing a goal for
regional innovation programs to assist a certain number or percentage of small businesses based
on these or other characteristics. Congress could direct existing business assistance programs,
such as MBDA and SBA initiatives, to prioritize projects located in areas served by RIS projects.
To evaluate federal RIS programs’ impact on small businesses, Congress may consider directing
agencies to track metrics related to small business participation and job creation outcomes. For
example, the SBA asked grantees setting up clusters in the Regional Innovation Clusters program

or sector-based economic prosperity by providing services for the purposes of accelerating the commercialization of
research. VDOs are defined in 15 USC § 3722(a)(4).” See EDA, “Economic Development Glossary,”
https://www.eda.gov/about/economic-development-glossary.
117 U.S. Congress, Senate Committee on Science, Commerce, and Transportation, Subcommittee on Communications,
Technology, Innovation, and the Internet, hearing on “Betting on the Rest: Expanding American Entrepreneurship
Outside Traditional Hubs,” 116th Cong., 2nd sess., December 15, 2020, https://www.commerce.senate.gov/2020/12/
betting-on-the-rest-expanding-american-entrepreneurship-outside-traditional-hubs.
118 Chen Yeh, “Why Are Startups Important for the Economy?” Federal Reserve Bank of Richmond Economic Brief,
No. 23-06, (February 2023), https://www.richmondfed.org/publications/research/economic_brief/2023/eb_23-06.
119 EDA, 2019 Regional Innovation Strategies Program, Notice of Funding Opportunity, January 31, 2019,
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312519.
120 For more information about the SBA’s Growth Accelerator Fund Competition Program, see CRS In Focus IF12310,
The Small Business Administration’s Growth Accelerator Fund Competition, by Adam G. Levin.
121 For example, since 1988, the federal government has maintained annual goals for small and small “disadvantaged”
business participation in federal contracting. The goals, which are in statute, specify percentages of federal contracts
that should go to certain businesses based on size or type of business owner. For more information, see CRS Insight
IN12018, Federal Small Business Contracting Goals. Additionally, for decades, Congress has directed the SBA to
provide small businesses with assistance through credit and technical assistance programs (e.g., the SBA 7(a) loan
guarantee, the SBA 504 loan program, the SBA Microloan program).
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to track metrics including growth in the number of small businesses participating in cluster
partnerships and growth in job creation of small businesses participating in the cluster.122
Concluding Remarks
Concerns about declining U.S. economic competitiveness and technological leadership—and the
potential implications for economic growth, productivity, employment, and national security—are
not new. For example, in the late 1970s and 1980s, the United States faced growing trade deficits,
slowing rates of productivity growth, and increased competition in industries such as
automobiles, steel, consumer electronics, and semiconductors. Congress responded to those
challenges, in part, by enacting legislation intended to improve U.S. development and
commercialization.
Current concerns are centered on the rise of China, with some asserting that it will soon surpass
the United States as the global leader in science and technology. Congress has responded to these
concerns, in part, by enacting legislation that will improve the innovation capacity of the nation
as a whole. The recent expansion of federal support for RIS policies may expand the nation’s
innovation capacity by helping regional economies address barriers to entrepreneurship and the
development and commercialization of certain technology areas. As such, the effective
implementation of regional innovation systems and strategies will likely remain an area of
congressional interest for the foreseeable future.

Author Information

Julie M. Lawhorn
Adam G. Levin
Analyst in Economic Development Policy
Analyst in Economic Development Policy

Marcy E. Gallo
Emily G. Blevins
Analyst in Science and Technology Policy
Analyst in Science and Technology Policy

Disclaimer
This document was prepared by the Congressional Research Service (CRS). CRS serves as nonpartisan
shared staff to congressional committees and Members of Congress. It operates solely at the behest of and
under the direction of Congress. Information in a CRS Report should not be relied upon for purposes other
than public understanding of information that has been provided by CRS to Members of Congress in
connection with CRS’s institutional role. CRS Reports, as a work of the United States Government, are not
subject to copyright protection in the United States. Any CRS Report may be reproduced and distributed in
its entirety without permission from CRS. However, as a CRS Report may include copyrighted images or
material from a third party, you may need to obtain the permission of the copyright holder if you wish to
copy or otherwise use copyrighted material.

122 SBA, SBA—Regional Innovation Cluster Initiative Services—2018 Performance-Based Statement of Work, 2018,
https://sam.gov/api/prod/opps/v3/opportunities/resources/files/49614056be72fe01d0c5d49c3e0a2ab3/download.
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