The National Nanotechnology Initiative: 
Overview, Reauthorization, and 
Appropriations Issues 
John F. Sargent Jr. 
Specialist in Science and Technology Policy 
January 19, 2011 
Congressional Research Service
7-5700 
www.crs.gov 
RL34401 
CRS Report for Congress
P
  repared for Members and Committees of Congress        
The National Nanotechnology Initiative 
 
Summary 
Nanotechnology—a term encompassing the science, engineering, and applications of submicron 
materials—involves the harnessing of unique physical, chemical, and biological properties of 
nanoscale substances in fundamentally new and useful ways. The economic and societal promise 
of nanotechnology has led to substantial and sustained investments by governments and 
companies around the world. In 2000, the United States launched the world’s first national 
nanotechnology program. From FY2001 through FY2010, the federal government invested 
approximately $12.4 billion in nanoscale science, engineering, and technology through the U.S. 
National Nanotechnology Initiative (NNI). President Obama requested $1.8 billion in NNI 
funding for FY2011, a level generally supported by the current continuing resolution (P.L. 111-
322). U.S. companies and state governments have invested billions more. As a result of this focus 
and these investments, the United States has, in the view of many experts, emerged as a global 
leader in nanotechnology. However, the competition for global leadership in nanotechnology is 
intensifying as countries and companies around the world increase their investments. 
Nanotechnology’s complexity and intricacies, early stage of development (with commercial pay-
off possibly years away for many potential applications), and broad scope of potential 
applications engender a wide range of public policy issues. Maintaining U.S. technological and 
commercial leadership in nanotechnology poses a variety of technical and policy challenges, 
including development of technologies that will enable commercial scale manufacturing of 
nanotechnology materials and products; environmental, health, and safety (EHS) concerns; and 
maintenance of public confidence in its safety. 
Congress established programs, assigned responsibilities, and initiated research and development 
(R&D) related to these issues in the 21st Century Nanotechnology Research and Development Act 
of 2003 (P.L. 108-153). While many provisions of this act have no sunset provision, FY2008 was 
the last year of agency authorizations included in the act. Legislation to amend and reauthorize 
the act was introduced in the House (H.R. 5940, 110th Congress) and the Senate (S. 3274, 110th 
Congress) in the 110th Congress. The House passed H.R. 5940 by a vote of 407-6; the Senate did 
not act on S. 3274. In January 2009, H.R. 554 (111th Congress), the National Nanotechnology 
Initiative Amendments Act of 2009, was introduced in the 111th Congress. The act contained 
essentially the same provisions as H.R. 5940. In February 2009, the House passed the bill by 
voice vote under a suspension of the rules. The bill was referred to the Senate Committee on 
Commerce, Science, and Transportation; no further action was taken. On May 7, 2010, the House 
Committee on Science and Technology reported the America COMPETES Reauthorization Act of 
2010 (H.R. 5116, 111th Congress) which included, as Title I, Subtitle A, the National 
Nanotechnology Initiative Amendments Act of 2010. This title was removed from the bill prior to 
enactment.  
Proponents of the NNI assert that nanotechnology is one of the most important emerging and 
enabling technologies and that U.S. competitiveness, technological leadership, national security, 
and societal interests require an aggressive approach to the development and commercialization 
of nanotechnology. Critics of the NNI voice concerns that reflect disparate underlying beliefs. 
Some critics assert that the government is not doing enough to move technology from the 
laboratory into the marketplace. Others argue that the magnitude of the public investment may 
skew what should be market-based decisions in research, development, and commercialization. 
Still other critics say that the inherent risks of nanotechnology are not being addressed in a timely 
or effective manner.  
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Contents 
Introduction ................................................................................................................................ 1 
Overview .................................................................................................................................... 2 
National Nanotechnology Initiative ............................................................................................. 7 
Vision and Goals................................................................................................................... 7 
History.................................................................................................................................. 8 
Legislative Approach ............................................................................................................ 8 
21st Century Nanotechnology Research and Development Act of 2003 ............................ 9 
Reauthorization Efforts ................................................................................................. 11 
Structure ............................................................................................................................. 12 
Nanoscale Science, Engineering, and Technology Subcommittee................................... 12 
National Nanotechnology Coordination Office .............................................................. 13 
Funding .............................................................................................................................. 14 
Agency Funding............................................................................................................ 16 
Program Component Area Funding ............................................................................... 18 
Centers, Networks, and User Facilities ................................................................................ 23 
Selected NNI Reports and Assessments ..................................................................................... 24 
Selected NNI Reports.......................................................................................................... 24 
The National Nanotechnology Initiative: Research and Development Leading to a 
Revolution in Technology and Industry, Supplement to the President’s FY2011 
Budget ....................................................................................................................... 25 
The National Nanotechnology Strategic Plan (2007)...................................................... 25 
Strategy for Nanotechnology-related Environmental, Health, and Safety Research ........ 26 
Prioritization of Environmental, Health, and Safety Research Needs for 
Engineered Nanoscale Materials: An Interim Document for Public Comment ............. 27 
The National Nanotechnology Initiative: Environmental, Health, and Safety 
Research Needs for Engineered Nanoscale Materials.................................................. 27 
Selected NNI Assessments .................................................................................................. 28 
The National Nanotechnology Initiative: Second Assessment and 
Recommendations of the National Nanotechnology Advisory Panel, President’s 
Council of Advisors on Science and Technology ........................................................ 28 
Addendum to the National Nanotechnology Initiative: Second Assessment and 
Recommendations of the National Nanotechnology Advisory Panel, President’s 
Council of Advisors on Science and Technology ........................................................ 30 
A Matter of Size: Triennial Review of the National Nanotechnology Initiative............... 31 
The National Nanotechnology Initiative at Five Years: Assessment and 
Recommendations of the National Nanotechnology Advisory Panel, President’s 
Council of Advisors on Science and Technology ........................................................ 35 
Selected Nanotechnology Legislation in the 111th Congress....................................................... 38 
Title I, Subtitle A, H.R. 5116 (111th Congress)—National Nanotechnology Initiative 
Amendments Act of 2010................................................................................................. 38 
H.R. 554 (111th Congress)—National Nanotechnology Initiative Amendments Act of 
2009 ................................................................................................................................ 38 
S. 1482 (111th Congress)—National Nanotechnology Amendments Act of 2009 ................. 40 
S. 596 (111th Congress)—Nanotechnology Innovation and Prize Competition Act of 
2009 ................................................................................................................................ 42 
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H.R. 820 (111th Congress)—Nanotechnology Advancement and New 
Opportunities Act ............................................................................................................. 43 
H.R. 2647 (111th Congress)—National Defense Authorization Act for Fiscal Year 
2010 ................................................................................................................................ 44 
S. 3117 (111th Congress)—Promote Nanotechnology in Schools Act .................................. 44 
H.R. 4502 (111th Congress)—Nanotechnology Education Act ............................................ 44 
S. 2942 (111th Congress)—Nanotechnology Safety Act of 2010.......................................... 45 
H.R. 5786 (111th Congress)—Safe Cosmetics Act of 2010................................................... 45 
Concluding Observations .......................................................................................................... 45 
 
Figures 
Figure 1. Organizations With a Role in the National Nanotechnology Initiative and Their 
Relationships ......................................................................................................................... 15 
 
Tables 
Table 1. NNI Funding, by Agency: FY2001-FY2010 and FY2011 Request................................ 17 
Table 2. NNI Funding, by Program Component Area, FY2006-FY2010 and FY2011 
Request .................................................................................................................................. 19 
 
Appendixes 
Appendix A. Selected Reports on the National Nanotechnology Initiative ................................. 47 
Appendix B. List of NNI and Nanotechnology-Related Acronyms............................................. 49 
 
Contacts 
Author Contact Information ...................................................................................................... 50 
 
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Introduction 
Nanotechnology has been an issue of interest to Congress for a number of years, coming into 
focus in 2000 with the launch of the U.S. National Nanotechnology Initiative (NNI) by President 
Clinton in his FY2001 budget request to Congress. From FY2001 through FY2011, Congress 
appropriated approximately $14.2 billion for nanotechnology research and development (R&D).1 
These efforts have been directed at advancing understanding and control of matter at the 
nanoscale,2 where the physical, chemical, and biological properties of materials differ in 
fundamental and useful ways from the 
properties of individual atoms or bulk 
Nanotechnology:  A Description 
matter.3 
The term “nanotechnology” is often used as an al -
encompassing term for nanoscale science, engineering, and 
The development and application of 
technology. Nanotechnology is the understanding and 
nanotechnology—more fully explained 
control of matter at dimensions of roughly 1 to 100 
nanometers, the size-scale between individual atoms and 
below—across a wide array of products and 
bulk materials, where unique phenomena enable novel 
industries holds the potential for significant 
applications. A nanometer is one-billionth of a meter, or 
economic and societal benefits. To capture 
about the width of 10 hydrogen atoms arranged side-by-
these benefits, the United States will have to 
side in a line. Nanotechnology involves imaging, measuring, 
modeling, and manipulating matter at this size-scale. 
effectively address a variety of technical and 
policy challenges that stand as potential 
At the nanoscale, the physical, chemical, and biological 
barriers to commercialization, including 
properties of materials can differ in fundamental and useful 
ways from the properties of individual atoms and molecules 
environmental, health, and safety (EHS) 
or bulk matter. Nanotechnology R&D is directed toward 
concerns and their implications for 
understanding and creating improved materials, devices, and 
workplace, environmental, food, and drug 
systems that exploit these new properties. 
regulations; development of standards, 
Physicist Richard Feynman’s remarks at the 1959 annual 
reference materials, and consistent 
meeting of the American Physical Society are often cited as 
nomenclature; development of new 
the first articulation of and vision for nanotechnology. 
measurement methods and tools; effective 
Though he did not use the term nanotechnology in this 
speech, he spoke of controlling matter at the nanoscale and 
technology transfer to the private sector; 
creating atomic-level machines, positing some of the 
protection of intellectual property; 
applications that doing so might enable. 
availability, affordability, and patience of 
Source: The National Nanotechnology Initiative Strategic Plan, 2004, 
investment capital; ethical, legal, and 
Nanoscale Science, Engineering, and Technology Subcommittee, 
societal concerns; public understanding, 
National Science and Technology Council, The White House, 
support, and acceptance; and development 
December 2004. 
of a world-class scientific and technical 
nanotechnology workforce. 
This report provides an overview of nanotechnology, the National Nanotechnology Initiative, 
possible reauthorization of the 21st Century Nanotechnology Research and Development Act of 
2003 (P.L. 108-153), and appropriations issues. 
                                                             
1 This figure assumes approximately $1.8 billion in funding for FY2011 based on the current continuing resolution 
providing the same level of funding provided in FY2010.  
2 In the context of the NNI and nanotechnology, the nanoscale refers to a dimension of 1 to 100 nanometers (see box on 
this page). 
3 While extensive R&D has been, and continues to be, conducted to understand and harness the properties of individual 
atoms, this is not the domain of nanotechnology. 
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Overview 
The economic and societal promise of nanotechnology has led to involvement and investments by 
governments and companies around the world. In 2000, the United States became the first nation 
to establish a formal, national initiative to advance nanoscale science, engineering, and 
technology—the National Nanotechnology Initiative. Through FY2011, Congress has 
appropriated approximately $14.2 billion in nanoscale science, engineering, and technology 
through the NNI. U.S. companies and state governments have invested billions more. 
As a result of this focus and these investments, the United States has emerged as a global leader 
in nanotechnology. However, the competition for global leadership is intensifying as foreign 
investments in nanoscale science, engineering, and technology increase. Other nations have 
followed the U.S. lead and established their own national nanotechnology programs, each with 
varying degrees of investment, foci, and support for industrial applications and 
commercialization. Today, almost every nation that supports R&D has a national-level 
nanotechnology program. 
Global public investments in nanotechnology in 2009 alone were estimated to be $9.8 billion, 
with cumulative global public investments through 2009 reaching approximately $50 billion.4 In 
2005, an assessment of the NNI by the President’s Council of Advisors on Science and 
Technology (PCAST) reported that the United States leads all other nations in public investments 
in nanotechnology R&D, accounting for about a quarter of global annual public investments.5 An 
April 2009 report by Cientifica, a privately held nanotechnology business analysis and consulting 
firm, states that the U.S. share of global public nanotechnology funding has fallen to 19% in 2009 
from 31% in 2004, calculated on a currency exchange rate basis, behind Russia (23%) and the 
European Union (EU) States (collectively, 27%).6 The situation appears even less favorable when 
the share of investment is calculated on a purchasing power parity (PPP) basis (which takes into 
account the price of goods and services in each nation). Using a PPP approach, Cientifica 
concluded in its report that the U.S. share of global public nanotechnology investments is 16%, 
less than Russia (25%) and the EU States (27%), and the same as China (16%).7 
Global investments in nanotechnology already have begun to yield economic benefits as products 
incorporating nanotechnology enter the marketplace. These products are estimated to have 
produced $147 billion in revenues in 2007 (including $59 billion in the United States, $47 billion 
in Europe, $31 billion in Asia/Pacific, and $9 billion in other nations).8 By tapping the unique 
properties that emerge at the nanoscale, proponents maintain that nanotechnology holds the 
potential for products that could transform existing industries and create new ones, clean and 
                                                             
4 Nanotechnology Takes a Deep Breath…and Prepares to Save the World, Cientifica, April 2009, available at 
http://www.cientifica.eu/files/Whitepapers/Nanotechnology%20Takes%20a%20Deep%20Breath.pdf. 
5 The National Nanotechnology Initiative at Five Years: Assessment and Recommendations of the National 
Nanotechnology Advisory Panel, President’s Council of Advisors on Science and Technology, May 2005, available at 
http://www.nano.gov/html/res/FINAL_PCAST_NANO_REPORT.pdf. 
6 Nanotechnology Takes a Deep Breath…and Prepares to Save the World, Cientifica, April 2009, available at 
http://www.cientifica.eu/files/Whitepapers/Nanotechnology%20Takes%20a%20Deep%20Breath.pdf.  
7 Ibid. 
8 “Overhyped Technology Starts to Reach Potential,” press release, Lux Research, July 22, 2008. 
http://www.luxresearchinc.com/press/RELEASE_Nano-SMR_7_22_08.pdf. Numbers do not add to total due to 
rounding. 
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protect the environment, extend and improve the quality of our lives, and strengthen national 
security. Most nanotechnology products currently on the market—such as faster computer 
processors, higher density memory devices, lighter-weight auto parts, stain-resistant clothing, 
antibiotic bandages, cosmetics, and clear sunscreen—are evolutionary in nature, offering 
incremental improvements in characteristics such as performance, aesthetics, cost, size, and 
weight. 
Evolutionary nanotechnology products, however, represent only a small fraction of what many 
see as the substantial longer-term economic and societal promise of nanotechnology. One 
estimate projects nanotechnology product revenues will reach $3.1 trillion by 2015,9 while 
another estimate projects revenues will reach $2.95 billion by 2015, of which almost half will 
come from semiconductors.10, 11 
Many nanotechnology advocates—including business executives, scientists, engineers, medical 
professionals, and venture capitalists—assert that in the longer term, nanotechnology, especially 
in combination with information technology, biotechnology, and the cognitive sciences, may 
deliver revolutionary advances, including: 
•  new prevention, detection, and treatment technologies that could reduce 
substantially death and suffering from cancer and other deadly illnesses;12 
•  new organs to replace damaged or diseased ones;13 
•  contact lenses, skin patches, and glucose-sensing tattoos that monitor diabetics’ 
blood sugar levels and warn when too high or low;14 
•  clothing that protects against toxins and pathogens;15 
•  clean, inexpensive, renewable power through energy creation, storage, and 
transmission technologies;16 
•  inexpensive, portable water purification systems that provide universal access to 
safe water;17 
•  energy efficient, low-emission “green” manufacturing systems;18 
                                                             
9 Ibid 
10 Halfway to the Trillion Dollar Market: A Critical Review of the Diffusion of Nanotechnologies, Cientifica, 2007. 
http://www.cientifica.eu/files/Whitepapers/A%20Reassessment%20of%20the%20Trillion%20WP.pdf 
11 While views vary on how to calculate nanotechnology’s contribution to these products, the consensus is that 
nanotechnology is likely to have a significant economic impact and transformative effect on many industries. 
12 National Cancer Institute website. http://nano.cancer.gov/resource_center/tech_backgrounder.asp 
13 Ibid. 
14 Aslan, Kadir; Lakowicz, Joseph R.; and Geddes, Chris D. “Nanogold plasmon resonance-based glucose sensing. 
Wavelength-ratiometric resonance light scattering,” Analytical Chemistry, 2005, Vol. 77. Strategic Plan for Pediatric 
Urology, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Department of 
Health and Human Services, February 2006. 
15 Risbud, Aditi. “Fruit of the Nano Loom,” Technology Review, February 2006. 
16 Nanoscience Research for Energy Needs, Nanoscale Science, Engineering, and Technology Subcommittee, National 
Science and Technology Council, The White House, December 2004. 
17 Risbud, Aditi. “Cheap Drinking Water from the Ocean,” Technology Review, June 2006. 
18 Selko, Adrienne. “New Nanotechnology-Based Coatings Are Energy Efficient and Environmentally Sound,” 
Industry Week, August 22, 2007. “Tomorrow’s Green Nanofactories,” Science Daily, July 11, 2007. 
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•  high-density memory systems capable of storing the entire Library of Congress 
collection on a device the size of a sugar cube;19 
•  agricultural technologies that increase crop yield and improve nutritional value, 
reducing global hunger and malnutrition;20 
•  self-repairing materials;21 
•  powerful, small, inexpensive sensors that can warn of minute levels of toxins and 
pathogens in air, soil, or water;22 and 
•  decontaminated industrial sites through environmental remediation.23 
While some applications of nanotechnology have proven market-ready, much fundamental 
research remains ahead, including efforts to advance understanding of nanoscale phenomena; 
characterize nanoscale materials; understand how to control and manipulate nanoscale particles; 
develop instrumentation and measurement methods; and understand how nanoscale particles 
interact with humans, animals, plants, and the environment. In addition, several federal 
agencies—such as the Departments of Defense, Energy, and Homeland Security—see the 
potential for nanotechnology to help address mission requirements. Historically, the federal 
government has played a central role in funding these types of research and development 
activities. 
Though federal nanoscale science, engineering, and technology R&D had been underway for over 
a decade, the NNI was first initiated as a Presidential technology initiative in 2000.24 The original 
participating agencies were the National Science Foundation (NSF), the Department of Defense 
(DOD), the Department of Energy (DOE), the Department of Commerce’s (DOC) National 
Institute of Standards and Technology (NIST), the National Aeronautics and Space 
Administration (NASA), and the Department of Health and Human Services’ National Institutes 
of Health (NIH). In 2010, 25 agencies participated in the NNI, including 14 that received 
appropriations to conduct and/or fund nanotechnology R&D. Since its first year of funding in 
                                                             
19 National Nanotechnology Initiative—Leading to the Next Industrial Revolution, Interagency Working Group on 
Nanoscience, Engineering, and Technology, National Science and Technology Council, The White House. 
http://www.ostp.gov/NSTC/html/iwgn/iwgn.fy01budsuppl/nni.pdf 
20 21st Century Agriculture: A Critical Role for Science and Technology, U.S. Department of Agriculture, June 2003; 
and Nanoscale Science and Engineering for Agriculture and Food Systems: Draft Report of the National Planning 
Workshop to the Cooperative State Research, Education, and Extension Service of the U.S. Department of Agriculture, 
July 2003. 
21 Nanotechnology in Space Exploration, Nanoscale Science, Engineering, and Technology Subcommittee, National 
Science and Technology Council, The White House, August 2004, available at http://www.nano.gov/
nni_space_exploration_rpt.pdf. 
22 Nanotechnology and the Environment, Nanoscale Science, Engineering, and Technology Subcommittee, National 
Science and Technology Council, The White House, May 2003, available at http://www.nano.gov/
NNI_Nanotechnology_and_the_Environment.pdf. 
23 Proceedings of the U.S. Environmental Protection Agency Workshop on Nanotechnology for Site Remediation, U.S. 
Environmental Protection Agency, October 2005. 
24 “National Nanotechnology Initiative: Leading to the Next Industrial Revolution,” press release, The White House, 
January 21, 2000. http://clinton4.nara.gov/WH/New/html/20000121_4.html; and “Steering the technology that will 
redefine life as we know it,” Industrial Biotechnology, Vol. 1, No. 3, Fall 2005. http://www.nsf.gov/crssprgm/nano/
reports/mcr_ind_biotech_interview.pdf 
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FY2001, the NNI’s annual appropriations have grown nearly four-fold to an estimated $1.8 
billion in FY2010.25 
In 2003, Congress provided a statutory foundation for some of the activities of the NNI through 
the 21st Century Nanotechnology Research and Development Act of 2003 (P.L. 108-153). The act 
established a National Nanotechnology Program (NNP) and provided authorizations for a subset 
of the NNI agencies, namely the NSF, DOE, NASA, NIST, and Environmental Protection Agency 
(EPA).26 The act, however, did not address the participation of several agencies that fund 
nanotechnology R&D under the NNI, including DOD, NIH, and the Department of Homeland 
Security (DHS). Nevertheless, coordination of nanotechnology R&D activities across all NNI 
funding agencies continues under the National Science and Technology Council’s (NSTC’s) 
Nanoscale Science, Engineering, and Technology (NSET) subcommittee.27 According to the 
NSET subcommittee’s 2004 NNI Strategic Plan, “For continuity and to capture this broader 
participation, the coordinated federal activities as a whole will continue to be referred to as the 
National Nanotechnology Initiative.” Accordingly, the functions and activities established under 
the act are incorporated into the executive branch’s implementation of the NNI. 
The thrust of the NNI has primarily been the development of fundamental scientific knowledge 
through basic research. Investments at mission agencies, such as DOD, have supported 
nanotechnology applications development for which they are a primary customer. Other 
investments have supported infrastructural technologies. For example, NIST has contributed to 
developing tools and standards that enable measurement and control of matter at the nanoscale, 
thereby supporting the conduct of R&D and the ability to manufacture nanoscale materials and 
products. As understanding of nanotechnology has matured, the NNI has worked with a variety of 
industry organizations to facilitate the movement of research results from the laboratory bench to 
the marketplace in fields as disparate as semiconductors, chemicals, energy, concrete, and forest 
products. 
The NNI agencies also have begun to address research needs and regulatory issues related to 
environmental, health, and safety issues, as well as issues such as public understanding and 
workforce education and training. The NNI agencies actively engage in a variety of international 
fora, such as the Organization for Economic Cooperation and Development (OECD) and the 
International Standards Organization (ISO), to cooperatively address nanotechnology issues 
related to EHS, metrology28 and standards, nomenclature, and nanoscale materials 
characterization. 
                                                             
25 This figure includes $1.657 billion in regular appropriations and $0.140 billion in funding provided by the American 
Recovery and Reinvestment Act of 2009 (P.L. 111-5). 
26 While many provisions of this act have no sunset provision, FY2008 was the last year of agency authorizations 
included in the act. 
27 Prior to P.L. 108-153, the Bob Stump Defense Authorization Act for Fiscal Year 2003 (P.L. 107-314) required DOD 
to “provide for interagency cooperation and collaboration on nanoscale research and development.” The NSET 
subcommittee is a subcommittee of the NSTC Committee on Technology. 
28 Metrology is the science of measurement, including the equipment and processes used to produce a measurement. 
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Maintaining U.S. leadership poses a variety of technical, economic, and policy challenges, 
including: 
•  safeguarding the environment and ensuring human health and safety; 
•  creating the standards, reference materials, nomenclature, methods, and tools for 
metrology to enable the manufacturing of nanoscale materials and products; 
•  developing a world-class scientific and technical nanotechnology workforce; 
•  translating research results into products, including effective technology transfer 
to the private sector; 
•  understanding public perceptions and attitudes and fostering public 
understanding; 
•  addressing ethical, legal and societal implications; 
•  protecting intellectual property; 
•  securing investment capital for early-stage research, development, and 
commercialization; and 
•  fostering and facilitating international cooperation and coordination. 
Proponents of the NNI assert that nanotechnology is one of the most important emerging and 
enabling technologies29 and that U.S. competitiveness, technological leadership, national security, 
and societal interests require an aggressive approach to the development and commercialization 
of nanotechnology. Critics of the NNI hold a variety of competing views, asserting that 
government is not doing enough, is doing too much, or is moving too quickly. 
Some in industry have criticized the NNI for being overly focused on basic research and not 
being aggressive enough in moving NNI-funded R&D out of government and university 
laboratories and into industry. Others in industry have criticized the federal government for not 
providing mechanisms to help advance nanotechnology R&D to the point where it becomes 
economically viable for venture capitalists, corporations, and other investors to create products 
and bring them to market. Some refer to this gap as the “valley of death.”30 Still others in industry 
have criticized the NNI for not adequately supporting the development of metrology, standards, 
equipment, and processes necessary to manufacture nanotechnology materials, products, and 
systems at a commercial scale. 
Conversely, supporters of industry-driven market investments contend that extensive government 
support for nanotechnology may supplant the judgment of the marketplace by picking “winners 
and losers” in technological development. For example, the size and directions of the NNI 
investments may encourage industry to follow the government’s lead rather than independently 
selecting R&D directions itself or, alternatively, may result in the promotion of a less effective 
                                                             
29 The Department of Commerce has characterized emerging and enabling technologies as those that “offer a wide 
breadth of potential application and form an important technical basis for future commercial applications.” (ATP Rule, 
15 C.F.R. Part 295). 
30 The term “valley of death” is used by business executives, economists, and venture capitalists to describe the 
development gap that often exists between a laboratory discovery and the market’s willingness to invest to advance the 
discovery to a final commercial product. This gap occurs due to a variety of issues, such as technical risk, market 
uncertainty, and likelihood of obtaining an adequate return on investment. 
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technology path over a more effective one. These supporters also assert that federal government 
funding of scientific research is often wasteful, driven by political considerations and not 
scientific merit.31 
Some non-governmental organizations (NGO) are critical of nanotechnology for its potential 
adverse impacts on human health and safety and on the environment. They assert that the 
government is pushing ahead too quickly in developing nanotechnology and encouraging its 
commercialization and use without adequately investing in research focused on understanding 
and mitigating negative EHS implications.32 They argue that the very characteristics that make 
nanotechnology promising also present significant potential risks to human health and safety and 
the environment. Some of these critics argue for application of the “precautionary principle,” 
which holds that regulatory action may be required to control potentially hazardous substances 
even before a causal link has been established by scientific evidence.33 At least one NGO has 
called for a moratorium on nanotechnology R&D and new commercial products incorporating 
synthetic nanoparticles.34 
National Nanotechnology Initiative 
The National Nanotechnology Initiative is an interagency program that coordinates federal 
nanoscale science, engineering, and technology R&D activities and related efforts among 
participating agencies. 
Vision and Goals 
The National Science and Technology Council (NSTC) has stated the following vision for 
the NNI: 
A future in which the ability to understand and control matter on the nanoscale leads to a 
revolution in technology and industry. The NNI will expedite the discovery, development, 
and deployment of nanotechnology in order to achieve responsible and sustainable economic 
benefits, to enhance the quality of life, and to promote national security.35 
                                                             
31 Crews, Clyde Wayne, Jr., “Washington’s Big Little Pork Barrel: Nanotechnology,” Cato Institute website, May 29, 
2003. 
32 Testimony of Andrew Maynard, Chief Science Advisor, Project on Emerging Nanotechnologies, Woodrow Wilson 
International Center for Scholars, “Research on Environmental and Safety Impacts of Nanotechnology: Current Status 
of Planning and Implementation under the National Nanotechnology Initiative,” hearing, Subcommittee on Research 
and Science Education, House Committee on Science and Technology, October 31, 2007. 
33 “NGOs urge precautionary principle in use of nanomaterials,” EurActiv.com, June 14, 2007. 
http://www.euractiv.com/en/environment/ngos-urge-precautionary-principle-use-nanomaterials/article-164619 Sass, 
Jennifer. “Nanotechnology and the Precautionary Principle,” presentation, Natural Resources Defense Council, 2006. 
http://docs.nrdc.org/health/hea_06121402a.pdf The precautionary principle has been used in other countries on some 
issues. For example, the Biosafety Protocol to the 1992 Convention on Biological Diversity incorporates provisions 
applying the precautionary principle to the safe handling, transfer, and trade of genetically modified organisms. For 
further information, see CRS Report RL30594, Biosafety Protocol for Genetically Modified Organisms: Overview, by 
Alejandro E. Segarra and Susan R. Fletcher. 
34 “No Small Matter II: The Case for a Global Moratorium—Size Matters!,” Occasional Paper Series, ETC Group, 
April 2003. http://www.etcgroup.org/upload/publication/pdf_file/165 
35 The National Nanotechnology Initiative Strategic Plan, Nanoscale Science, Engineering, and Technology 
(continued...) 
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To achieve its vision, the NNI has established four goals: maintain a world-class R&D program 
aimed at realizing the full potential of nanotechnology; facilitate transfer of new technologies into 
products that provide economic growth, jobs, and other public benefits; develop educational 
resources, a skilled workforce, and the supporting infrastructure and tools to advance 
nanotechnology; and support responsible development of nanotechnology.36 
History 
Attempts to coordinate federal nanoscale R&D began in November 1996, as staff members from 
several agencies met regularly to discuss their plans and programs in nanoscale science and 
technology. This group continued informally until September 1998, when it was designated as the 
Interagency Working Group on Nanotechnology (IWGN) under the NSTC. In August 1999, 
IWGN completed its first draft of a plan for an initiative in nanoscale science and technology, 
which was subsequently approved by the President’s Council of Advisors on Science and 
Technology (PCAST) and the White House Office of Science and Technology Policy (OSTP).37 
In his 2001 budget submission to Congress, then-President Clinton raised nanotechnology-related 
research to the level of a federal initiative, officially referring to it as the National 
Nanotechnology Initiative.38 
Legislative Approach 
Congress has played a central role in the National Nanotechnology Initiative, providing 
appropriations for the conduct of nanoscale science, engineering, and technology research; 
establishing programs; and creating a legislative foundation for the activities of the NNI. 
Congressional funding for the NNI is provided through appropriations to each of the NNI-
participating agencies. The NNI has no centralized funding. The overall NNI budget is calculated 
by aggregating the nanotechnology budgets for each of the federal agencies that conduct or 
provide funding for nanoscale science, engineering, and technology research. 
In FY2001, the first year of NNI funding, Congress provided $464 million to eight agencies for 
nanoscale science, engineering, and technology research.39 The NNI has continued to receive 
support from both Congress and the White House. Both the number of agencies participating in 
the NNI and the size of the federal investment have grown. Currently 25 agencies participate in 
                                                             
(...continued) 
Subcommittee, National Science and Technology Council, The White House, December 2004, available at 
http://www.nano.gov/NNI_Strategic_Plan_2004.pdf. 
36 Ibid. 
37 National Nanotechnology Initiative website. http://www.nano.gov/html/about/history.html 
38 “National Nanotechnology Initiative: Leading to the Next Industrial Revolution,” press release, The White House, 
January 21, 2000. http://clinton4.nara.gov/WH/New/html/20000121_4.html; and National Nanotechnology Initiative 
website. http://www.nano.gov/html/about/history.html 
39 In its January 21, 2001 press release, “National Nanotechnology Initiative: Leading to the Next Industrial 
Revolution,” announcing the establishment of the NNI, the White House identified only six participating agencies—
NSF, DOD, DOE, NIST, NASA, and NIH. Subsequently, EPA and DOJ reported nanotechnology R&D funding in 
FY2001, bringing the total number of agencies funding nanotechnology R&D in FY2001 to eight. 
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The National Nanotechnology Initiative 
 
the NNI, 14 of which received appropriated funds for nanotechnology R&D in FY2010.40 Total 
NNI funding in FY2010 was approximately $1.8 billion, more than three times the level of 
funding provided in FY2001. The original six agencies identified at the launch of the NNI41 still 
account for the vast majority of NNI funding (96.3% in FY2010). 
21st Century Nanotechnology Research and Development Act of 2003 
Congress codified and further defined some of the NNI’s activities in the 21st Century 
Nanotechnology Research and Development Act of 2003 which was passed by Congress in 
November 2003, and signed into law (P.L. 108-153) by President Bush on December 3, 2003.42 
The legislation received strong bipartisan support in both the House of Representatives, which 
passed the bill on a recorded vote of 405-19, and in the Senate, which passed the bill by 
unanimous consent. 
Though this act is often referred to as the enabling legislation for the National Nanotechnology 
Initiative, the act actually establishes a National Nanotechnology Program (NNP). The act 
provides authorizations for five NNI agencies—the National Science Foundation, Department of 
Energy, NASA, National Institute of Standards and Technology, and Environmental Protection 
Agency—but not for the Department of Defense, National Institutes of Health, Department of 
Homeland Security,43 or other NNI research agencies that collectively accounted for 46% of NNI 
funding in FY2003. 
The act created the NNP for the purposes of establishing the goals, priorities, and metrics for 
evaluation of federal nanotechnology research, development, and other activities; investing in 
federal R&D programs in nanotechnology and related sciences to achieve those goals; and 
providing for interagency coordination of federal nanotechnology research, development, and 
other activities undertaken pursuant to the NNP. 
                                                             
40 NNI participants include agencies that either conduct or provide funding for nanotechnology R&D, as well as 
agencies with missions that may affect the development, commercialization, and use of nanotechnology. For example, 
in the latter case, the Food and Drug Administration may regulate (or not regulate) nanotechnology products, the U.S. 
Patent and Trademark Office’s (USPTO) treatment of nanotechnology-related patents may affect the value of the 
underlying intellectual property, and the execution of the missions of the Departments of Education and Labor could 
affect the preparedness of the U.S. workforce for emerging nanotechnology jobs. Some nanotechnology R&D agencies 
may also have non-R&D missions related to nanotechnology. For example, EPA conducts and funds R&D but also has 
a regulatory mission that could affect nanotechnology research, development, production, use, and/or disposal. 
41 The original six agencies identified at the launch of the NNI were the Department of Defense, Department of Energy, 
National Institute of Standards and Technology (Department of Commerce), National Science Foundation, National 
Aeronautics and Space Administration, and National Institutes of Health (DHHS). “National Nanotechnology 
Initiative: Leading to the Next Industrial Revolution,” press release, The White House, January 21, 2000. 
http://clinton4.nara.gov/WH/New/html/20000121_4.html; and National Nanotechnology Initiative website. 
http://www.nano.gov/html/about/history.html 
42 U.S. Congress. 2003. 21st Century Nanotechnology Research and Development Act. P.L. 108-153. 15 U.S.C. 7501. 
108 Cong., December 3.  
43 FY2003 funding attributed to DHS for the purpose of this calculation is based on nanotechnology R&D 
appropriations received by the Department of Transportation’s Transportation Security Administration (TSA). TSA 
was transferred to DHS in the Homeland Security Act of 2002 (P.L. 107-296) which was enacted after the start of 
FY2003. 
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Key provisions of the act include: 
•  authorizing appropriations for the nanotechnology-related activities of the 
National Science Foundation, Department of Energy, NASA, National Institute 
of Standards and Technology, and Environmental Protection Agency for fiscal 
years 2005 through 2008, totaling $3.679 billion for the four year period; 
•  establishing a National Nanotechnology Coordination Office, with a director and 
full time staff to provide administrative support to the NSTC; 
•  establishing a National Nanotechnology Advisory Panel (NNAP) to advise the 
President and the NSTC on matters relating to the NNP. 
•  establishing a triennial review of the NNP by the National Research Council of 
the National Academies of Sciences; 
•  directing the NSTC to oversee the planning, management, and coordination of 
the program, including the development of a triennial strategic plan; 
•  directing the Department of Commerce’s National Institute of Standards and 
Technology to establish a program to conduct basic research on issues related to 
the development and manufacture of nanotechnology, and to use the 
Manufacturing Extension Partnership program to ensure results reach small- and 
medium-sized manufacturing companies; 
•  directing the Secretary of Commerce to use the National Technical Information 
Service to establish a clearinghouse of information related to commercialization 
of nanotechnology research; 
•  directing the Secretary of Energy to establish a program to support consortia to 
conduct interdisciplinary nanotechnology R&D designed to integrate newly 
developed nanotechnology and microfluidic tools with systems biology and 
molecular imaging; 
•  directing the Secretary of Energy to carry out projects to develop, plan, construct, 
acquire, operate, or support special equipment, instrumentation, or facilities for 
investigators conducting nanotechnology R&D; and 
•  directing the establishment of two centers, on a merit-reviewed and competitive 
basis: (1) the American Nanotechnology Preparedness Center, to conduct, 
coordinate, collect, and disseminate studies on the societal, ethical, 
environmental, educational, legal, and workforce implications of 
nanotechnology; and to identify anticipated issues related to the responsible 
research, development, and application of nanotechnology, as well as provide 
recommendations for preventing or addressing such issues, and (2) the Center for 
Nanomaterials Manufacturing, to encourage, conduct, coordinate, commission, 
collect, and disseminate research on new manufacturing technologies for 
materials, devices, and systems with new combinations of characteristics, such 
as, but not limited to, strength, toughness, density, conductivity, flame resistance, 
and membrane separation characteristics; and to develop mechanisms to transfer 
such manufacturing technologies to U.S. industries. 
While the act establishes a National Nanotechnology Program, the executive branch continues its 
broader effort under the NNI framework and name. According to the NNI’s 2004 Strategic Plan: 
Congressional Research Service 
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The National Nanotechnology Initiative 
 
Many of the activities outlined in the Act were already in progress as part of the NNI. 
Moreover, the ongoing management of the initiative involves considerable input from 
Federal agencies that are not named specifically in the Act.... For continuity, and to capture 
this broader participation, the coordinated Federal activities as a whole will continue to be 
referred to as the National Nanotechnology Initiative.44 
Reauthorization Efforts 
The 21st Century Nanotechnology Research and Development Act provided a legislative 
foundation for some of the activities of the NNI, authorized agency funding levels through 
FY2008, and sought to address challenges associated with the development and 
commercialization of nanotechnology. While many provisions of this act have no sunset 
provision, FY2008 was the last year of agency authorizations included in the act.  
Legislation to amend and reauthorize the act was introduced in the House in both the 110th 
Congress and 111th Congress: 
•  H.R. 5940 (110th Congress) and S. 3274 (110th Congress) were both titled the 
National Nanotechnology Initiative Amendments Act of 2008. The House passed 
H.R. 5940 by a vote of 407-6; the Senate did not act on S. 3274.  
•  H.R. 554 (111th Congress), the National Nanotechnology Initiative Amendments 
Act of 2009, contained essentially the same provisions as H.R. 5940 (110th 
Congress). In February 2009, the House passed the bill by voice vote under a 
suspension of the rules. The Senate did not act on H.R. 554. 
•  S. 1482 (111th Congress), the National Nanotechnology Initiative Amendments 
Act of 2009, was introduced in the Senate and referred to the Committee on 
Commerce, Science, and Transportation. No further action was taken.  
•  H.R. 820 (111th Congress), the Nanotechnology Advancement and New 
Opportunities Act, also would have amended P.L. 108-153. The provisions of 
H.R. 820 covered a variety of jurisdictions, thus the bill was assigned to multiple 
House committees. No further action was taken. 
•  On May 7, 2010, the House Committee on Science and Technology reported the 
America COMPETES Reauthorization Act of 2010 (H.R. 5116, 111th Congress) 
which included, as Title I, Subtitle A, the “National Nanotechnology Initiative 
Amendments Act of 2010.” Provisions of this subtitle were nearly identical to the 
provisions of H.R. 554 (111th Congress). This title was removed from the bill 
prior to its enactment.  
For additional information on these bills, see “Selected Nanotechnology Legislation in the 111th 
Congress.” 
                                                             
44 The National Nanotechnology Initiative Strategic Plan, Nanoscale Science, Engineering, and Technology 
Subcommittee, National Science and Technology Council, The White House, December 2004, available at 
http://www.nano.gov/NNI_Strategic_Plan_2004.pdf. 
Congressional Research Service 
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The National Nanotechnology Initiative 
 
Structure 
Nanoscale Science, Engineering, and Technology Subcommittee 
The NNI is coordinated within the White House through the NSTC, the Cabinet-level council by 
which the President coordinates science, space, and technology policies across the federal 
government. Operationally, NNI coordination is accomplished through the Nanoscale Science, 
Engineering, and Technology (NSET) subcommittee of the NSTC’s Committee on Technology 
(CT). The NSET subcommittee also has an informal reporting relationship to the NSTC’s 
Committee on Science (CS). The NSET subcommittee is led by an agency co-chair, currently 
from the Department of Energy (DOE), and an OSTP co-chair. The NSET subcommittee is 
comprised of representatives from 25 federal entities (including 15 that have funded, over the 
course of the NNI, nanotechnology R&D), OSTP and the Office of Management and Budget.45 
The NSET subcommittee has established several working groups, each taking on efforts in key 
subject areas.46 Among them: 
National Environmental and Health Implications (NEHI) 
The National Environmental and Health Implications (NEHI) working group was chartered to 
provide for exchange of information among agencies that support research and those responsible 
for regulations and guidelines related to nanotechnology products; to facilitate identification, 
prioritization, and implementation of research and other activities required for the responsible 
research, development, utilization, and oversight of nanotechnology; and to promote 
communication of information related to research on environmental and health implications of 
nanotechnology to other government agencies and non-government parties. To this end, the NEHI 
working group seeks to identify and prioritize environmental, health, and safety research needs 
related to nanotechnology. Twenty NNI agencies participate in the NEHI working group, and 13 
agencies fund safety-related nanotechnology research and/or have regulatory authorities to guide 
the safe use of nanomaterials.47 
                                                             
45 The agencies that participate in the NSET subcommittee comprise the NNI. NSET subcommittee members include 
Bureau of Industry and Security, Department of Commerce; Consumer Product Safety Commission; National Institute 
of Food and Agriculture, Department of Agriculture; Department of Defense; Department of Education; Department of 
Energy; Department of Homeland Security; Department of Justice; Department of Labor; Department of State; 
Department of Transportation; Department of the Treasury; Environmental Protection Agency; Food and Drug 
Administration; Forest Service, Department of Agriculture; Director of National Intelligence; International Trade 
Commission; National Aeronautics and Space Administration; National Institutes of Health, U.S. Department of Health 
and Human Services; National Institute for Occupational Safety and Health, Center for Disease Control, Department of 
Health and Human Services; National Institute of Standards and Technology, Department of Commerce; National 
Science Foundation; Nuclear Regulatory Commission; U.S. Geological Survey; and U.S. Patent and Trademark Office, 
Department of Commerce. The Department of Commerce’s Technology Administration was a participating agency in 
the NNI until its elimination in August 2007 under the America COMPETES Act (P.L. 110-69). 
46 The National Nanotechnology Initiative: Research and Development Leading to a Revolution in Technology and 
Industry-Supplement to the President’s FY2008 Budget, Nanoscale Science, Engineering, and Technology 
Subcommittee, National Science and Technology Council, The White House, July 2007, available at 
http://www.nano.gov/NNI_08Budget.pdf. 
47 Testimony of E. Clayton Teague, Director, National Nanotechnology Coordinating Office, Research on 
Environmental and Safety Impacts of Nanotechnology: Current Status of Planning and Implementation under the 
(continued...) 
Congressional Research Service 
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The National Nanotechnology Initiative 
 
Nanomanufacturing, Industry Liaison, and Innovation(NILI) 
The Nanomanufacturing, Industry Liaison, and Innovation (NILI) working group was chartered 
to enhance collaboration and information sharing between U.S. industry and government on 
nanotechnology-related activities. It also facilitates federal, regional, state, and local 
nanotechnology R&D and commercialization activities. In addition, the NILI working group is to 
create innovative methods for transferring federally funded technology to industry. The NILI 
working group has facilitated collaborations between the NNI and the semiconductor/electronics 
industry, chemical industry, forest products industry, and the Industrial Research Institute.48 
Global Issues in Nanotechnology (GIN) 
The Global Issues in Nanotechnology (GIN) working group was chartered to monitor foreign 
nanotechnology programs and development; broaden international collaboration on 
nanotechnology R&D, including safeguarding the environment and human health; and promote 
U.S. commercial and trade interests in nanotechnology. The NEHI working group works with the 
GIN working group to coordinate the U.S. position and participation in international activities 
related to environmental, health, and safety implications of nanotechnology. The GIN working 
group facilitates international collaboration on pre-competitive and non-competitive aspects of 
nanotechnology, and international engagement on trade, commercialization and regulatory issues. 
Nanotechnology Public Engagement and Communications (NPEC)  
The Nanotechnology Public Engagement and Communications (NPEC) working group was 
established to develop approaches by which the NNI can communicate more effectively with the 
public. 
National Nanotechnology Coordination Office 
The National Nanotechnology Coordination Office (NNCO) provides administrative and 
technical support to the NSET subcommittee. Initially established in 2001 through a 
memorandum of understanding among the NNI participating agencies,49 the NNCO was 
authorized by the 21st Century Nanotechnology Research and Development Act of 2003 (P.L. 
108-153). The NNCO was charged under the act with providing technical and administrative 
support to the NSTC and NNAP; serving as the point of contact for information on federal 
nanotechnology activities for the exchange of technical and programmatic information among 
stakeholders; conducting public outreach; and promoting access to and early application of NNP 
technologies, innovation, and expertise. 
The act authorizes the work of the NNCO to be funded by contributions from NSET 
subcommittee member agencies. According to the NNCO, funding is provided through a 
                                                             
(...continued) 
National Nanotechnology Initiative, hearing, Subcommittee on Research and Science Education, House Committee on 
Science and Technology, October 31, 2007. 
48 The Industrial Research Institute is an association of companies and federally funded laboratories with the mission of 
improving R&D capabilities through the development and dissemination of best practices. 
49 National Nanotechnology Initiative website, http://www.nano.gov. 
Congressional Research Service 
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The National Nanotechnology Initiative 
 
memorandum of understanding signed by eight NNI agencies.50 In principle, each agency 
contributes to the NNCO budget in proportion to its share of the President’s total nanotechnology 
budget request for the signatory agencies. However, two of the signatories, EPA and DOT, had 
sufficiently small enough nanotechnology budgets in the early years of the NNI that they were 
not expected to contribute. EPA now contributes to funding the NNCO. Total NNCO funding 
from the agencies in FY2010 was $2.4 million. In addition, the NNCO has carried over FY2009 
funds intended to support a National Academies’ study, bringing the total NNCO budget for 
FY2010 to just under $3 million. 
Funding 
The NNI supports fundamental and applied research on nanotechnology by funding research, 
creating multidisciplinary centers of excellence, and developing key research infrastructure. It 
also supports activities aimed at addressing the societal implications of nanotechnology, including 
ethical, legal, human and environmental health, and workforce issues. 
This section provides information on NNI funding from two perspectives: organizationally by 
agency and functionally by program component area. 
                                                             
50 The eight agencies that are signatories to the memorandum of understanding are NSF, DOD, DOE, NIH, NIST, 
NASA, EPA, and DOT. 
Congressional Research Service 
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The National Nanotechnology Initiative 
 
Figure 1. Organizations With a Role in the National Nanotechnology Initiative 
and Their  Relationships 
 
Source: The National Nanotechnology Strategic Plan, Nanoscale, Science, Engineering, and Technology 
Subcommittee, National Science and Technology Council, The White House, December 2007. 
(Nanomanufacturing working group added to chart in cited source.) 
 
Congressional Research Service 
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The National Nanotechnology Initiative 
 
Agency Funding 
The NNI budget is an aggregation of the nanotechnology components of the individual budgets of 
NNI-participating agencies. The NNI budget is not a single, centralized source of funds that is 
allocated to individual agencies. In fact, agency nanotechnology budgets are developed internally 
as part of each agency’s overall budget development process. These budgets are subjected to 
review, revision, and approval by the Office of Management and Budget and become part of the 
President’s annual budget submission to Congress. The NNI budget is then calculated by 
aggregating the nanotechnology components of the appropriations provided by Congress to each 
federal agency. 
For FY2010, regular appropriations for NNI agencies totaled an estimated $1.781 billion,51 a 
$79.5 million (4.7%) increase over the FY2009 regular appropriation and nearly four times the 
$464 million federal investment in nanotechnology research in FY2001. This growth in 
nanotechnology R&D investments reflects expectations in Congress and in the executive branch 
that the NNI will expand fundamental knowledge and make important contributions to national 
priorities. The chronology of NNI funding is detailed in Table 1. 
President Obama requested $1.762 billion in funding for the NNI in FY2011, a decrease of $19.5 
million (1.1%). The FY2011 NNI budget request would support a broad range of programs 
among 14 agencies. Agencies with the largest budgets are: 
•  NSF, which supports fundamental nanotechnology research across science and 
engineering disciplines; 
•  DOD, whose investments in nanotechnology are aimed at addressing the 
department’s national security mission; 
•  DOE, which supports nanotechnology research providing a basis for new and 
improved energy efficiency, production, storage, and transmission technologies; 
•  NIH, which emphasizes nanotechnology-based biomedical advances occurring at 
the intersection of biology and the physical sciences; and 
•  NIST, which focuses on research in instrumentation, measurement, standards, 
characterization, and nanomanufacturing. 
Other agencies investing in mission-related nanotechnology R&D are NASA, EPA, the 
Cooperative State Research, Education, and Extension Service (CSREES) and Forest Service at 
the Department of Agriculture (USDA), National Institute of Occupational Safety and Health 
(NIOSH), DHS, Department of Justice (DOJ), Department of Transportation’s (DOT’s) Federal 
Highway Administration (FHWA), and the Consumer Product Safety Commission (CPSC). 
                                                             
51 This figure does not include NNI funding provided by ARRA. Agency ARRA allocations included $511.2 million 
for nanotechnology R&D. Agencies may report additional ARRA funding for SBIR and STTR projects later, when 
2009 SBIR/STTR data become available. 
Congressional Research Service 
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Table 1. NNI Funding, by Agency: FY2001-FY2010 and FY2011 Request 
(in millions of current dollars) 
FY  
FY  
FY  
FY  
FY  
FY  
FY  
FY  
FY  
ARRA
2001 
2002 
2003 
2004 
2005 
2006 
2007 
2008 
2009 
(P.L. 
FY2010 
FY2011 
Agency 
Actual 
Actual 
Actual 
Actual 
Actual 
Actual 
Actual 
Actual 
Actual 
111-5)a 
Estimate 
Request 
National 
Science 
Foundation 
150 204 221 256 335 360 389 409 409 101  418  401 
Department of Defenseb 
125 224 220 291 352 424 450 460 459 
  436  349 
Department 
of 
Energy 
88  89 134 202 208 231 236 245 333 293  373  424 
National 
Institutes 
of 
Health 
(HHS) 
40  59  78 106 165 192 215 305 343  73  361  382 
Nat’l 
Inst. 
of 
Standards 
and 
Tech. 
(DOC) 
33 77 64 77 79 78 88 86 93 43  114 108 
Environmental 
Protection 
Agency 
5 6 5 5 7 5 8 12 12    18 20 
NASA 
22 35 36 47 45 50 20 17 14    14  16 
Department 
of 
Justice 
1 1 1 2 2 <1 2 0 1    0   
Department 
of 
Homeland 
Security 
 
 2 1 1 1 2 2 3 9    12 12 
Nat’l Inst. of Food and Agriculture (USDA)c   
   
 1 2 3 4 4 6 10    10  9 
Nat’l Inst. for Occupational Safety (HHS) 
  
  
  
  
3 
4 
7 
7 
7 
 
10 
17 
Forest Service (USDA) 
  
  
  
  
  
2 
3 
5 
5 
 
5 
5 
Federal Highway Administration (DOT) 
  
  
  
  
  
1 
1 
1 
1 
 
3 
2 
Food 
and 
Drug 
Administration 
(HHS) 
        7   7 15 
Consumer Product Safety Commission 
 
 
 
 
 
 
 
 
<1 
 
<1 
2 
TOTALd 
464  697  760  989 1,200 1,351 1,425 1,554 1,702  511  1,781  1,762 
Sources: NNI website, http://www.nano.gov. 
a.  Funding figures for nanotechnology-related R&D under the ARRA are preliminary estimates. 
b.  According to NSTC, the DOD budgets shown above for FY2006, FY2007, FY2008, and FY2009 include congressional y directed funding of approximately $76 million 
in FY2006, $63 million in FY2007, and $117 million in FY2009; the NSTC states that the DOD budget for FY2010 also includes congressional y directed funding but 
does not provide an amount. According to NSTC, the 2008 DOD estimate “includes many earmarks that are outside the NNI plan.” 
c.  Formerly, the USDA Cooperative State Research, Education, and Extension Service (CSREES).  
d.  Totals may not add due to rounding of agency budget figures. 
 
CRS-17 
The National Nanotechnology Initiative 
 
Program Component Area Funding 
The 21st Century Nanotechnology R&D Act of 2003 called for the NSET subcommittee to 
develop categories of investment called Program Component Areas (PCA) to provide a means by 
which Congress and the executive branch can be informed of and direct the relative investments 
in these areas. The PCAs are categories of investments that cut across the needs and interests of 
individual agencies and contribute to the achievement of one or more of the NNI’s goals. The 
2004 NNI strategic plan identified seven PCAs. The 2007 NNI strategic plan splits the seventh 
PCA, Societal Dimensions, into two PCAs: Environment, Health, and Safety; and Education and 
Societal Dimensions. A description of the seven initial PCAs and their current funding is provided 
below,52 as well as a description of the two derivative PCAs.53 The chronology of NNI funding by 
PCA is detailed in Table 2. 
In the following analysis of funding for each of the PCAs, comparisons involving FY2009 
funding (i.e., between FY2010 and FY2009) exclude ARRA funding. In addition, comparisons 
between the President’s FY2011 budget request and estimated FY2010 appropriations may be 
affected by the President’s exclusion of congressionally directed funding in his budget. 
                                                             
52 The National Nanotechnology Initiative Strategic Plan, Nanoscale Science, Engineering, and Technology 
Subcommittee, National Science and Technology Council, The White House, December 2004, http://www.nano.gov/
NNI_Strategic_Plan_2004.pdf. 
53 The National Nanotechnology Initiative Strategic Plan, Nanoscale Science, Engineering, and Technology 
Subcommittee, National Science and Technology Council, The White House, December 2007, available at 
http://www.nano.gov/NNI_Strategic_Plan_2007.pdf. 
Congressional Research Service 
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Table 2. NNI Funding, by Program Component Area, FY2006-FY2010 and FY2011 Request 
(in millions of current dollars) 
FY2006  
FY2007  
FY2008  
FY2009  
ARRA 
FY2010 
FY2011 
PCA 
Actual 
Actual 
Actual 
Actual 
Preliminary 
Estimate 
Request 
Fundamental Phenomena and Processes 
455.9 
480.6 
478.5 
479.2 
130.6 
467.9 
484.4 
Nanomaterials 
265.1 258.3 285.1 331.9  178.3 373.5 342.3 
Nanoscale 
Devices 
and 
Systems 
319.6 344.7 372.7 435.2  68.0 429.9 402.0 
Instrumentation 
Research, 
Metrology, 
and 
Standards 
51.0 52.5 69.0 90.8  12.4 84.3 76.9 
Nanomanufacturing 
33.8 48.1 47.1 75.6  28.5 96.7 101.4 
Major Research Facilities and Instrumentation Acquisition 
152.4 
152.4 
196.4 177.6  72.5 197.3 203.0 
Societal 
Dimensions 
73.5        
- 
Environment, 
Health, 
and 
Safety 
 48.3 67.9 74.5  12.0 91.6 116.9 
- 
Education 
& 
Societal 
Dimensions 
 39.2 37.7 36.8 
9 39.9 34.8 
TOTALa 
1,351.2 1,424.1 1,554.4 1,701.5 
511.3 1,781.1 1,761.6 
Source: The National Nanotechnology Initiative: Research and Development Leading to a Revolution in Technology and Industry, Supplement to the President’s FY2008 Budget, 
Nanoscale Science, Engineering, and Technology Subcommittee, National Science and Technology Council, The White House, July 2007. National Nanotechnology Initiative: 
FY2009 Budget & Highlights, National Science and Technology Council, The White House, February 2008. The National Nanotechnology Initiative: Research and Development 
Leading to a Revolution in Technology and Industry, Supplement to the President’s FY2010 Budget, Nanoscale Science, Engineering, and Technology Subcommittee, National 
Science and Technology Council, The White House, May 2009. 
a.  Details may not add to totals due to rounding. 
 
CRS-19 
The National Nanotechnology Initiative 
 
Fundamental Phenomena and Processes 
Fundamental Phenomena and Processes includes investments in the discovery and development 
of fundamental knowledge pertaining to the new phenomena in the physical, biological, and 
engineering sciences that occur at the nanoscale, as well as in understanding and articulation of 
scientific and engineering principles related to nanoscale structures, processes, and mechanisms. 
FY2010 funding for Fundamental Phenomena and Processes fell to $467.9 million, down $11.3 
million (2.4%) from the FY2009 level due primarily to a decrease in DOD funding in this PCA 
(down $24.0 million, 14.7%). President Obama’s FY2011 budget proposed $484.4 million in 
funding, up $16.5 million (3.5%) over the FY2010 level due primarily to increases in DOE ($14.2 
million, 13.8%) and DOD ($412.7 million, 9.1%) funding. The increase in DOE and DOD 
funding would be somewhat offset by a decrease in NSF funding of $12.5 million (8.2%).54 
Nanomaterials 
Nanomaterials includes research investments to discover novel nanoscale and nanostructured 
materials. This PCA also attempts to understand the properties of nanomaterials, and supports 
R&D to enable the design and synthesis, in a controlled manner, of nanoscale materials with 
targeted properties. 
FY2010 funding for Nanomaterials rose to $373.5 million, up $41.6 million (12.5%) from the 
FY2009 level, led by an increase in DOE funding in this PCA (up $21.7 million, 23.4%). 
President Obama’s FY2011 budget proposed $342.3 million for this PCA, a decrease of $31.2 
million (8.4%) from the FY2010 level, resulting primarily from reduced DOD funding (down 
$36.0 million, 47.8%).55  
Nanoscale Devices and Systems 
Nanoscale Devices and Systems include R&D investments that apply nanoscale science and 
engineering principles to create novel devices and systems or to improve existing ones. It also 
includes the use of nanoscale or nanostructured materials to achieve improved performance or 
new functionality. To meet this definition, the enabling science and technology must be at the 
nanoscale, but the systems and devices are not restricted to that size. 
Funding for Nanoscale Devices and Systems fell to $429.9 million in FY2010, down $5.3 million 
(1.2%) from the FY2009 level. President Obama’s FY2011 budget proposed $402.0 million in 
funding for this PCA, a decrease of $27.9 million (6.5%) from the FY2010 level, largely due to 
reductions in DOD funding (down $49.0 million, 33.1%). The decrease in DOD funding for this 
PCA would be somewhat offset by increases in DOE ($13.2 million, 76.7%) and NIH funding 
($13.1 million, 7.2%).56 
                                                             
54 The National Nanotechnology Initiative: FY2010 Budget & Highlights, Nanoscale Science, Engineering, and 
Technology Subcommittee, National Science and Technology Council, The White House, May 2009, available at 
http://www.nano.gov/NNI_2010_budget_supplement.pdf. 
55 Ibid. 
56 Ibid. 
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Instrumentation Research, Metrology, and Standards 
The Instrumentation Research, Metrology, and Standards PCA includes R&D investments for 
development of tools needed to advance nanotechnology research and commercialization. 
Instrumentation for characterization, measurement, synthesis, and design of nanotechnology 
materials, structures, devices, and systems is funded through this PCA. R&D and other activities 
related to development of standards, including standards for nomenclature, materials, 
characterization, testing, and manufacture, are also in this PCA. 
FY2010 funding for Instrumentation Research, Metrology, and Standards fell to $84.3 million, 
down $6.5 million (7.2%) from the FY2009 level. President Obama’s FY2011 budget proposed 
$76.9 million in funding for this PCA, a decrease of $7.4 million (8.8%) from the FY2010 level, 
due to decreases in DOD, DOE, and NSF funding.57 
Nanomanufacturing 
Nanomanufacturing R&D supports the development of scalable, reliable, cost-effective 
manufacturing of nanoscale materials, structures, devices, and systems. It also includes R&D and 
integration of ultra-miniaturized top-down processes and complex bottom-up processes.58 
FY2010 funding for Nanomanufacturing rose to $96.7 million, up $21.1 million (27.9%) over the 
FY2009 level due primarily to increases in NIST ($17.8 million, 189.4%) and DOD ($8.2 
million, 28.3%) funding. President Obama’s FY2011 budget proposed $101.4 million for this 
PCA, an increase of $4.7 million (4.9%) above the FY2010 level as increases in DOE ($13.9 
million, 198.6%) and NSF ($9.8 million, 43.8%) would more than offset decreases in DOD 
($12.1 million, 32.5%) and NIST ($7.0 million, 25.7%) funding.59 
Major Research Facilities and Instrumentation Acquisition 
This PCA includes investments in the establishment and ongoing operations of user facilities and 
networks, the acquisition of major instrumentation, and other activities related to infrastructure 
for the conduct of nanoscale science, engineering, and technology R&D. 
FY2010 funding for Major Research Facilities and Instrumentation Acquisition rose to $197.3 
million, an increase of $19.7 million (11.1%) over the FY2009 level. President Obama’s FY2011 
budget proposed $203.0 million for this PCA, an increase of $5.7 million (2.9%) above the 
FY2009 level, led by increases in DOE and DOD funding.60 
                                                             
57 Ibid. 
58 Top-down processes are those that achieve design features by removing material from a larger block of material; 
bottom-up processes begin with smaller building blocks (atoms or molecules) and achieve design features by putting 
them together, possibly using self-assembly. 
59 The National Nanotechnology Initiative: FY2010 Budget & Highlights, Nanoscale Science, Engineering, and 
Technology Subcommittee, National Science and Technology Council, The White House, May 2009, available at 
http://www.nano.gov/NNI_2010_budget_supplement.pdf. 
60 Ibid. 
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Societal Dimensions 
The Societal Dimensions PCA includes investments in research and other activities that address 
the broad implications of nanotechnology to society. This includes assessing benefits and risks 
through research directed at environmental, health, and safety impacts of nanotechnology 
development; risk assessment of such impacts; education-related activities, such as development 
of materials for schools, undergraduate programs, technical training, and public outreach; and 
research directed at identifying and quantifying the broad implications of nanotechnology for 
society, including social, economic, workforce, educational, ethical, and legal implications. 
Under the 2007 NNI Strategic Plan, the Societal Dimensions PCA was divided into two separate 
PCAs: Environment, Health, and Safety, and Education and Societal Dimensions. Future PCA 
reporting will use the new eight PCA taxonomy. NSTC has retroactively reported FY2007 
Societal Dimensions PCA spending in the new PCAs.61 The NSET subcommittee characterizes 
the new PCAs as follows:62 
Environment, Health, and Safety 
This PCA addresses research primarily directed at understanding the environmental, health, and 
safety impacts of nanotechnology development and corresponding risk assessment, risk 
management, and methods for risk mitigation. 
FY2010 funding for Environment, Health, and Safety rose to $91.6 million, up $17.1 million 
(23.0%) above the FY2009 level, due to increases in EPA, NIH, NSF, and NIOSH funding. 
President Obama’s FY2011 budget proposed $116.9 million in funding for this PCA, an increase 
of $25.3 million (27.6%) above the FY2010 level, led by increases at FDA and NIOSH.63 
Education and Societal Dimensions 
This PCA addresses education-related activities such as development of materials for schools, 
undergraduate programs, technical training, and public communication, including outreach and 
engagement. Such activities include research directed at identifying and quantifying the broad 
implications of nanotechnology society, including social, economic, workforce, educational, 
ethical, and legal implications. 
FY2010 funding for Education and Societal Dimensions rose slightly to $39.9 million, up $3.1 
million (8.4%) from the FY2009 level due primarily to an increase in NSF funding ($3.0 million, 
9.6%); NSF accounts for 86.0% of funding in this PCA in FY2009. President Obama’s FY2011 
budget proposed $34.8 million in funding for this PCA, a decrease of $5.1 million (12.8%) from 
the FY2010 level, accounted for entirely by a decrease in NSF funding.64 
                                                             
61 The National Nanotechnology Initiative: FY2010 Budget & Highlights, Nanoscale Science, Engineering, and 
Technology Subcommittee, National Science and Technology Council, The White House, May 2009, available at 
http://www.nano.gov/NNI_2010_budget_supplement.pdf. 
62 Ibid. 
63 The National Nanotechnology Initiative: FY2010 Budget & Highlights, Nanoscale Science, Engineering, and 
Technology Subcommittee, National Science and Technology Council, The White House, May 2009, available at 
http://www.nano.gov/NNI_2010_budget_supplement.pdf. 
64 Ibid. 
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Centers, Networks, and User Facilities 
A key facet of the National Nanotechnology Initiative has been the development of an extensive 
infrastructure of interdisciplinary research and education centers, networks, and user facilities. 
The centers and user facilities are located at universities and federal laboratories across the 
country. 
Centers and networks provide opportunities and support for multidisciplinary research among 
investigators from a variety of disciplines and research sectors, including academia, industry, and 
government laboratories. Such multidisciplinary research not only can lead to advances in 
knowledge, but also may foster relationships that further the development of basic research 
results into devices and other applications. 
Many agencies support such centers. Examples of federal and federally supported centers include: 
•  The National Science Foundation has established university-based centers 
focused exclusively on nanotechnology, including 15 Nanoscale Science and 
Engineering Centers (NSEC), one Engineering Research Center, one Science and 
Technology Center, four Materials Research Science and Engineering Centers, 
two Nanoscale Science and Engineering Education Centers, and five Nanoscale 
Science and Engineering Networks.65 
•  The NIH has established more than 20 centers, including eight university-based 
Nanomedicine Development Centers; a Nanotechnology Characterization 
Laboratory, established by the National Cancer Institute (NCI), in partnership 
with NIST and the Food and Drug Administration; eight university-based Centers 
of Cancer Nanotechnology Excellence, established under the NCI’s Alliance for 
Nanotechnology in Cancer initiative; and four university-based centers, 
established by the National Heart, Lung, and Blood Institute under its Program of 
Excellence in Nanotechnology. 
•  The Department of Defense supports two university-based nanotechnology 
research centers, as well as the Institute for Nanoscience at the Naval Research 
Laboratory. 
•  NASA has established three centers under its University Research, Engineering, 
and Technology Institute program. 
•  The Department of Energy has established five Nanoscale Science Research 
Centers (NSRCs) co-located with its national labs. 
•  NIST has established a Center for Nanoscale Science and Technology (CNST). 
•  NIOSH has established a Nanotechnology Research Center to conduct research 
into the application of nanoparticles and nanomaterials in occupational safety and 
health and the implications of nanoparticles and nanomaterials for work-related 
injury and illness. 
                                                             
65 In addition, 18 other Materials Research Science and Engineering Centers conduct nanotechnology-related research 
as part of their overall efforts. 
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Many of the centers are designated as user facilities and are available to researchers not located at 
the center. User facilities are designed to allow outside researchers to take advantage of facilities, 
equipment, tools, and expertise. These shared resources provide researchers the opportunity to 
conduct research, characterize materials, and test products using equipment and facilities that 
their individual companies, universities, or organizations could not afford to acquire, support, or 
maintain. Conditions for user access vary by facility and agency. In general, users are not charged 
for pre-competitive, non-proprietary work leading to publication, and are charged on a cost-
recovery basis for proprietary work. In some cases, the user facilities are located at federal 
government laboratories (e.g., the Department of Energy’s five NSRCs, and the NIST CNST); 
other user facilities are located at universities and supported with federal funds (e.g., NSF’s 13 
university-based centers in the National Nanotechnology Infrastructure Network (NNIN)). 
As mentioned earlier, the 21st Century Nanotechnology R&D Act of 2003 directed the 
establishment of two centers, the American Nanotechnology Preparedness Center and the Center 
for Nanomaterials Manufacturing. According to the NSET subcommittee, the requirement to 
establish the American Nanotechnology Preparedness Center was met by NSF’s establishment of 
the Network for Nanotechnology in Society, comprised of centers at the University of California, 
Santa Barbara (with the participation of Harvard University and the University of South Carolina) 
and the University of Arizona.66 These centers were funded under NSF’s Nanoscale Science and 
Engineering Center (NSEC) program and did not include participation by any other NSET 
subcommittee agency.67 The NSET subcommittee states that the requirement for establishing the 
Center for Nanomaterials Manufacturing was met by NSF’s establishment of a National 
Nanomanufacturing Network (NNN) comprised of four NSECs. The Center for Integrated 
Hierarchical Manufacturing at the University of Massachusetts Amherst is the main node of the 
NNN.68 The NNN NSECs were established by NSF in collaboration with DOD and NIST, but 
exclusively with NSF funds.69 
Selected NNI Reports and Assessments 
This section presents summaries of recent reports from the NSTC’s Nanoscale Science, 
Engineering, and Technology Subcommittee and assessments conducted by the National Research 
Council and the President’s Council of Advisors on Science and Technology. 
Selected NNI Reports 
The NNI’s coordinating body, the NSTC’s Nanoscale Science, Engineering, and Technology 
Subcommittee, produces a variety of reports that serve to inform Congress and other key 
stakeholders on the initiatives’ current activities, investments, and priorities. 
                                                             
66 Private telephone communication between CRS and NSTC staff, January 31, 2008. 
67 Private e-mail communication between CRS and NSF staff, January 31, 2008. 
68 Private telephone communication between CRS and NSTC staff, January 31, 2008. 
69 Private e-mail communication between CRS and NSF staff, January 31, 2008. 
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The National Nanotechnology Initiative: Research and Development Leading 
to a Revolution in Technology and Industry, Supplement to the President’s 
FY2011 Budget70 
Each year the NSET subcommittee publishes a supplement to the President’s annual budget 
request. The FY2011 NNI budget supplement provides a more detailed look at NNI funding in the 
President’s budget request, including a break-out of the prior, current, and requested year budgets 
for each PCA. The report describes proposed changes in agency R&D budgets, as well as in the 
balance of investments by PCA. Of particular note: 
•  President Obama proposed an overall NNI budget for FY2011 of $1.762 billion, 
a $19.5 million (1.1%) decrease below FY2010 funding. 
•  Estimated funding for EHS R&D in FY2010 rose to $91.6 million, a 23.0% 
increase over FY2009. President Obama requested $116.9 million for EHS R&D 
in FY2011, an increase of $25.3 million (27.6%) over FY2010. 
•  President Obama’s FY2011 budget request reflected a decline in spending in 
several program component areas compared to FY2010 estimated funding levels, 
including nanomaterials, down $12.0 million (3.9%); nanoscale devices and 
systems, down $31.2 million (8.4%); nanoscale devices and systems, down $27.9 
million (6.5%), and instrumentation research, metrology and standards, down 
$7.4 million (8.8%). In addition to EHS funding, other program component areas 
to be increased included fundamental phenomena and processes, up $16.5 million 
(3.5%), major research facilities and instrumentation acquisition, up $5.7 million 
(2.9%), and nanomanufacturing, up $4.7 million (4.9%%). 
The National Nanotechnology Strategic Plan (2007)71 
The 21st Century Nanotechnology R&D Act of 2003 (P.L. 108-153) requires the NSTC to develop 
an NNI strategic plan every three years. This plan is to guide the program’s activities to meet the 
goals, priorities, and anticipated outcomes of the participating agencies. In addition, the act 
requires the triennial report to address how the program intends to move results out of the 
laboratory and into application for the benefit of society, its plan for long-term funding for 
interdisciplinary R&D, and the allocation of funding for interagency projects. The 2007 strategic 
plan is the first to follow external assessments by the National Academies and PCAST (operating 
as the NNAP) and seeks to incorporate the findings of these reviews. Of particular note: 
•  The 2007 strategic plan includes a new chapter on “High-Impact Application 
Opportunities and Critical Research Needs” possibly indicating an effort on the 
part of the Administration to move the NNI toward more directed research with 
commercial and societal benefits. Much of the early NNI work has been focused 
on basic research and mechanisms by which such research may produce 
                                                             
70The National Nanotechnology Initiative: FY2011 Budget & Highlights, Nanoscale Science, Engineering, and 
Technology Subcommittee, National Science and Technology Council, The White House, February 2010, available at 
http://www.nano.gov/NNI_2011_budget_supplement.pdf. 
71 The National Nanotechnology Strategic Plan, Nanoscale Science, Engineering, and Technology Subcommittee, 
National Science and Technology Council, The White House, December 2007, available at http://www.nano.gov/
NNI_Strategic_Plan_2007.pdf. 
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economic and societal dividends. Seven years into the NNI, the program is under 
increasing scrutiny to deliver the promised benefits. While the plan does not 
establish R&D or application targets per se, this chapter illustrates tangible 
benefits that may be achieved by research supported under the NNI. In addition, 
the plan provides a matrix that identifies which agencies have a central or 
supporting role in each key application area. The plan also provides a series of 
nanotechnology application-specific vignettes on topics such as early detection of 
life-threatening disease, smarter computers, more energy-efficient transportation, 
and energy security. 
•  The 2007 strategic plan split the Societal Dimensions PCA into two separate 
PCAs: Environmental, Health, and Safety, and Education and Societal 
Dimensions. This change responds to increased congressional and public 
attention to EHS needs. Some critics of the NNI had raised concerns that the 
inclusion of investments in education and other societal dimensions in the 
broader category obscured and artificially inflated the perception of investments 
in EHS R&D. 
•  The 2007 strategic plan also identifies four areas of common interest across 
agencies that is to be the focus of future workshops: sensors and nanoelectronics, 
energy, fate and transport of nanomaterials, and medical and health applications. 
Strategy for Nanotechnology-related Environmental, Health, and Safety 
Research72 
Strategy for Nanotechnology-related Environmental, Health, and Safety Research outlines the 
NNI’s strategy for addressing nanotechnology EHS concerns. The report outlines the process for 
developing a research strategy, including identification of priority needs, assessment of existing 
research, and analysis of strengths and weaknesses of the current portfolio of EHS-focused 
research. The report provides a summary and analysis of FY2006 EHS research projects using the 
five priority categories identified in the earlier report, The National Nanotechnology Initiative: 
Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials73 
(discussed below). The report concludes with a framework for addressing EHS research needs, 
including a summary and prioritization of research needs, an implementation strategy, and a 
discussion of interagency coordination efforts. 
 
                                                             
72 Strategy for Nanotechnology-related Environmental, Health, and Safety Research, Science, Engineering, and 
Technology Subcommittee, National Science and Technology Council, The White House, February 2008, available at 
http://www.nano.gov/NNI_EHS_Research_Strategy.pdf. 
73 The National Nanotechnology Initiative: Environmental, Health, and Safety Research Needs for Engineered 
Nanoscale Materials, Nanoscale Science, Engineering, and Technology Subcommittee, National Science and 
Technology Council, The White House, September 2006, available at http://www.nano.gov/
NNI_EHS_research_needs.pdf. 
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Prioritization of Environmental, Health, and Safety Research Needs for 
Engineered Nanoscale Materials: An Interim Document for Public Comment74 
This document is a follow-on to the Environmental, Health, and Safety Research Needs for 
Engineered Nanoscale Materials report (discussed below), incorporating public comments, 
refinements of the prioritization principles, and continued assessment of research needs. This 
report further identifies and defines five priorities within each of the five general categories of 
research needs established in the earlier document and presents the revised principles and the 
process used for this prioritization. The NEHI working group of the NSET subcommittee expects 
to use this report to evaluate the NNI’s current EHS research portfolio, perform a gap analysis, 
and identify opportunities for interagency collaboration. The report stresses that the NSET 
subcommittee is “pursuing a dynamic, open, and transparent process in developing an NNI EHS 
research strategy” and invites continuing public input. 
The National Nanotechnology Initiative: Environmental, Health, and Safety 
Research Needs for Engineered Nanoscale Materials75 
This report documents the efforts of the NSET subcommittee’s Nanotechnology Environmental 
and Health Implications (NEHI) working group to identify, prioritize, and implement research 
and other activities required for the responsible research and development of nanotechnology. The 
report is designed to help inform the research, risk assessment, and risk management activities of 
federal agencies and the private sector. 
The report identifies priority research within five general research areas: instrumentation, 
metrology, and analytical methods; nanomaterials and human health; nanomaterials and the 
environment; health and environmental surveillance; and risk management methods. 
The report identifies several next steps: 
•  prioritize research needs among those identified in the report; 
•  evaluate in greater detail the current NNI EHS research portfolio; 
•  perform a “gap analysis” of the NNI EHS research compared to the prioritized 
needs; 
•  coordinate and facilitate among the NNI agencies’ research programs to address 
priorities; and 
•  establish a process for periodic review of progress and for updating research 
needs and priorities. 
                                                             
74 Prioritization of Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials: An Interim 
Document for Public Comment, Nanoscale Science, Engineering, and Technology Subcommittee, National Science and 
Technology Council, The White House, August 2007, available at http://www.nano.gov/
Prioritization_EHS_Research_Needs_Engineered_Nanoscale_Materials.pdf. 
75 The National Nanotechnology Initiative: Environmental, Health, and Safety Research Needs for Engineered 
Nanoscale Materials, Nanoscale Science, Engineering, and Technology Subcommittee, National Science and 
Technology Council, The White House, September 2006, available at http://www.nano.gov/
NNI_EHS_research_needs.pdf. 
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The report concludes that conducting EHS research in parallel with the development of 
nanomaterials and their applications will help to ensure the full, safe, and responsible realization 
of the promise of nanotechnology, and that coordination of research activities among NNI-
participating agencies, as well as with industry and other governments, is necessary to expedite 
progress. In contrast, some NGOs have asserted the need for EHS research to precede the 
development of nanomaterials and nanotechnology applications. 
Selected NNI Assessments 
The 21st Century Nanotechnology R&D Act of 2003 (P.L. 108-153) requires periodic external 
reviews of the National Nanotechnology Program (NNP) by the National Research Council, an 
arm of the National Academies,76 and the National Nanotechnology Advisory Panel (NNAP).77 In 
general, these reviews concluded that the NNI has been successful so far and that its efforts are 
important to future U.S. technological leadership and commercial competitiveness. Both reports 
emphasize that much nanotechnology research is still in its very early stages and caution against 
expecting too much in the near term from this nascent technology. The reports also laud the 
cooperative efforts between the NNI and stakeholders in academia and industry and encourage 
increased interactions with industry, state and local economic developers, and, where appropriate, 
international partners. 
The National Nanotechnology Initiative: Second Assessment and 
Recommendations of the National Nanotechnology Advisory Panel, 
President’s Council of Advisors on Science and Technology78 
This report presents the findings of the second review of the NNI by the President’s Council of 
Advisors on Science and Technology’s, acting as the National Nanotechnology Advisory Panel, 
as mandated by the 21st Century Nanotechnology R&D Act of 2003. PCAST submitted its first 
report to the President on May 16, 2005, titled The National Nanotechnology Initiative at Five 
Years: Assessment and Recommendations of the National Nanotechnology Advisory Panel.  
As in earlier reports by PCAST and the National Research Council, this report concludes that the 
United States remains a leader in nanotechnology, though it recognizes the successful 
development of other nations’ nanotechnology research capabilities. The PCAST concluded that 
the NNI’s approach to addressing EHS research was “sound” and found proposals for a separate 
agency or office devoted to nanotechnology EHS research or to set aside a particular percentage 
of NNI funding for EHS research to be “misguided” and potentially counterproductive as 
resources may be directed away from research “on beneficial applications and on risk.” The panel 
                                                             
76 The National Research Council, the National Academy of Sciences, the National Academy of Engineering, and the 
Institute of Medicine are part of a private, non-profit institution established under a congressional charter. They are 
collectively referred to as the National Academies. 
77 P.L. 108-153 directs the President to “establish or designate a National Nanotechnology Advisory Panel.” In July 
2004, President Bush designated the President’s Council of Advisors on Science and Technology to serve as the NNAP 
by issuing Executive Order 13349, Amending Executive Order 13226 To Designate the President’s Council of Advisors 
on Science and Technology To Serve as the National Nanotechnology Advisory Panel. 
78 The National Nanotechnology Initiative: Second Assessment and Recommendations of the National Nanotechnology 
Advisory Panel, President’s Council of Advisors on Science and Technology, May 2005, available at 
http://www.whitehouse.gov/sites/default/files/microsites/ostp/PCAST-NNAP-NNI-Assessment-2008.pdf. 
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also concluded that nanotechnology does not raise ethical concerns unique from those 
accompanying other technological advances. The PCAST also concluded that the NNI is a 
“highly successful model for an interagency program” describing it as “well organized and well 
managed.”  
Recommendations 
The report made six broad recommendations for further strengthening the NNI, supported by 
more specific actions. They are: 
PCAST recommendation: 
Maintaining the world-class R&D infrastructure and strong interagency coordination created 
under the NNI is essential to achieving broad societal benefits from nanotechnology 
innovation.  
Some specific PCAST recommendations include continuing support for NNI multidisciplinary 
centers, networks and user facilities; improving coordination within agencies that have several 
operating divisions; and strengthening the participation of the Departments of Commerce, 
Education, and Labor to address education, training, market assessment, and standards 
development challenges related to nanotechnology. 
PCAST recommendation: 
Progress across the breadth of NNI-supported R&D critically depends upon the development 
and implementation of standards for nanomaterial identification, characterization, and risk 
assessment. 
In this regard, PCAST specifically recommended that federal agencies participate in the 
development of voluntary consensus-based standards; develop materials and analytical standards 
for nanotechnology EHS research; and work towards development of data sets of physical and 
chemical properties of nanomaterials. 
PCAST recommendation: 
Nanotechnology innovation through to commercialization depends on maintaining and 
strengthening cross-sector collaborations and cross-fertilization of technology development 
and business development expertise. 
Specifically, PCAST recommended expansion of efforts to assess national and international 
innovation and commercialization activities led by the Department of Commerce; expanded 
partnering between NNI multidisciplinary centers and economic development organizations; and 
educated more nanotechnology scientists and engineers to become entrepreneurs and skilled 
technology workers. 
PCAST recommendation: 
Nanotechnology research must be strategically guided, integrated, and coordinated across 
agencies, sectors, and countries, and include balanced assessment of risks and benefits in the 
context of specific, real-world applications. 
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Among the specific PCAST recommendations: improving coordination of federal EHS research 
efforts with industry and international stakeholders; preventing the segregation of research 
focused on EHS implications of nanotechnology from research focused on applications; 
continuing interagency collaboration on EHS research and mission-focused research; and 
distributing nonproprietary information about the properties of nanomaterials. 
PCAST recommendation: 
Research on the societal and ethical aspects of nanotechnology should both be integrated 
with technical R&D and take place in the context of broader societal and ethical leadership. 
PCAST recommendation: 
Public perception of and expectations related to nanotechnology should be informed based 
on sound science and balanced assessment of risks and benefits (known and anticipated) of 
specific innovations and their implications for society. 
PCAST recommended that the NNI more clearly demonstrate to the public the value of 
nanotechnology and NNI-supported R&D, calling for a more explicit and direct outreach 
approach to better inform and engage policymakers, stakeholders, and the general public. In 
addition PCAST recommended that NNI agencies should provided additional funding to the 
NNCO to support coordination among NNI agencies to enhance their agency-specific 
communication efforts. 
Addendum to the National Nanotechnology Initiative: Second Assessment 
and Recommendations of the National Nanotechnology Advisory Panel, 
President’s Council of Advisors on Science and Technology79 
PCAST submitted an addendum to its second assessment of the NNI in July 2008, providing an 
assessment of The National Nanotechnology Initiative Strategy for Nanotechnology-Related 
Environmental, Health, and Safety Research. The PCAST letter reaffirmed its judgment (as stated 
in its second assessment of the NNI) of the NNI’s approach to EHS research as “fundamentally 
sound in terms of strategic priorities as well as focus on and extent of collaboration across 
agencies, with industry, and particularly with international stakeholders.” PCAST found the 
NNI’s strategic approach to be “quite thorough and robust,” and stated that the NSET 
subcommittee’s NEHI working group 
remains the best locus of coordination and authoritative advisory capability for the 
participating agencies in implementing the government-wide nanotechnology EHS research 
strategy that cuts across agency and disciplinary lines.80 
PCAST made six recommendations with respect to the NNI’s EHS research strategy. First, 
PCAST recommended that an assessment of the federal nanotechnology EHS portfolio and gap 
                                                             
79 Addendum to The National Nanotechnology Initiative: Second Assessment and Recommendations of the National 
Nanotechnology Advisory Panel, President’s Council of Advisors on Science and Technology, May 2005, available at 
National Research Council, 2006, available at http://www.whitehouse.gov/sites/default/files/microsites/ostp/PCAST-
Addendum-Letter.pdf. 
80 Ibid. 
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analysis be performed once every three years noting that such a timetable would support the 
triennial reviews of PCAST and the NRC. Second, it proposed increased collaboration with 
industry and other countries to fill identified research gaps. Third, PCAST recommended that the 
NNI encourage its supported researchers to report on analytical methodologies used in their 
research to facilitate development of best practices for risk assessment and characterization. 
Fourth, PCAST stated that the NNI should promote broad and practical use of EHS findings in 
defining responsible use of nanotechnology in research, manufacturing, and commercial 
applications. Fifth, PCAST called for increased funding for exposure assessment in the context of 
manufacturing and disposal of nanomaterials and products incorporating relevant quantities of 
nanomaterials. Sixth, PCAST recommended that the NNI maintain and strengthen agency support 
and coordination efforts through the NSET subcommittee and the NEHI working group, 
specifically calling for  
all agencies that fund or conduct research on nanomaterials, as well as those agencies with 
charters that specifically include EHS-related activities, to directly support the NSET/NEHI 
data gathering and communications functions. 
A Matter of Size: Triennial Review of the National Nanotechnology Initiative81 
This 2006 report presents the findings of the National Research Council’s (NRC) first triennial 
review mandated by the 21st Century Nanotechnology R&D Act of 2003. 
The NRC study concluded that the NNI has been successful in coordinating nanoscale efforts and 
interests across the federal government, in catalyzing cooperative R&D across a variety of 
scientific and engineering disciplines, and in opening a host of new scientific opportunities 
through its infrastructure and R&D investments. The NRC attributed much of this success to 
effective communication and coordination by the NSET subcommittee and the NNCO. 
Recommendations 
Here are the recommendations made by the NRC followed by a discussion of each. 
NRC recommendation: 
the federal government [should] sustain investments in a manner that balances the pursuit of 
shorter-term goals with support for longer-term R&D and that ensures a robust supporting 
infrastructure, broadly defined. Supporting long-term research effectively will require 
making new funds available that do not come at the expense of much-needed ongoing 
investment in U.S. physical sciences and engineering research. 
President Bush has expressed support for increasing federal R&D funding for the physical 
sciences and engineering, most notably in his American Competitiveness Initiative which 
includes nanotechnology investments. Yet, as federal non-discretionary spending growth 
increases pressure on federal discretionary spending, finding new funds to support long-term 
nanotechnology research may need to come from other scientific disciplines. 
                                                             
81 A Matter of Size: Triennial Review of the National Nanotechnology Initiative, National Research Council, 2006, 
available at http://books.nap.edu/catalog.php?record_id=11752. 
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NRC recommendation: 
the federal government [should] establish an independent advisory panel with specific 
operational expertise in nanoscale science and engineering; management of research centers, 
facilities, and partnerships; and interdisciplinary collaboration to facilitate cutting-edge 
research on and effective and responsible development of nanotechnology. 
In July 2004, President George W. Bush implemented the provision of the 21st Century 
Nanotechnology Research and Development Act to “establish or designate a National 
Nanotechnology Advisory Panel” by issuing Executive Order 13349, which amends Executive 
Order 13226, designating the President’s Council of Advisors on Science and Technology to serve 
as the NNAP. 
The NRC’s recommendation suggests that the President’s designation of PCAST to serve as the 
legislatively mandated National Nanotechnology Advisory Panel is not fully adequate. Critics of 
the use of PCAST to serve as the NNAP maintain that the scope and depth of expertise needed to 
provide effective guidance on the NNI requires an independent panel of people with 
nanotechnology- and interdisciplinary-specific expertise and an undivided focus. Supporters of 
the use of PCAST for this function assert that a single advisory panel provides an integrated 
perspective, reduces unnecessary cost and management burdens, and that expertise can be added 
to the panel or accessed through non-member technical advisory groups. 
NRC recommendation: 
federal agencies participating in the NNI, in consultation with the NNCO and the Office of 
Management and Budget, should continue to develop and enhance means for consistent 
tracking and reporting of funds requested, authorized, and expended annually. The current 
set of PCAs provides an appropriate initial template for such tracking. 
It is difficult to assess and track funding for specific purposes within the NNI because the 
initiative is not centrally funded and operated. The NNI budget is an aggregation of the 
nanotechnology-related activities of the participating federal agencies. Congress funds the NNI-
related R&D on an agency-by-agency basis, with responsibilities crossing many authorizing 
committees and appropriations subcommittees. Thus, while it is relatively straightforward to 
quantify an agency’s nanotechnology budget, tracking all NNI investments related to a particular 
activity—EHS-related research, for example—is much more difficult. The PCAs serve to provide 
such a tracking mechanism. In addition, according to the 2007 National Nanotechnology 
Initiative Strategic Plan, the division of the Societal Dimensions PCA into two PCAs—
Environmental, Health, and Safety; and Educational and Societal Dimensions—is intended to 
better understand and manage the NNI investment. Such a change indicates a level of flexibility 
that may enable the executive branch and Congress to more effectively manage and balance 
investments in discrete areas of the NNI. 
NRC recommendation: 
the NSET Subcommittee [should] carry out or commission a study on the feasibility of 
developing metrics to quantify the return to the U.S. economy from the federal investment in 
nanotechnology R&D. The study should draw on the Department of Commerce’s expertise 
in economic analysis and its existing ability to poll U.S. industry. Among the activities for 
which metrics should be developed and relevant data collected are technology transfer and 
commercial development of nanotechnology. 
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Few efforts have been made within the federal government to understand the economic impacts 
of the nation’s investments in the NNI. Identification and tracking of data that could serve as an 
indicator of success in commercializing nanotechnology research or the effects on U.S. job 
creation or retention has not been formalized. To the extent that federal assessments of the 
economic contribution of and/or potential for nanotechnology products have occurred, they have 
not been performed with analytical rigor. Although the Commerce Department retains its 
economic analysis expertise, resident primarily in the Economics and Statistics Administration’s 
Bureau of Economic Analysis, the department’s Technology Administration, which led 
Commerce’s NNI activities and had government-wide responsibilities for technology transfer 
activities, was eliminated in August 2007.82 Prior to its elimination, the Technology 
Administration contracted for two studies that could contribute to addressing this NRC 
recommendation: an analysis of barriers to nanotechnology commercialization performed by the 
University of Illinois at Springfield, and an analysis of innovation metrics conducted by the 
Alliance for Science and Technology Research in America (ASTRA). These reports are publicly 
available at Commerce Department websites.83 
NRC recommendation: 
research on the environmental, health, and safety effects of nanotechnology [should] be 
expanded. Assessing the effects of engineered nanomaterials on public health and the 
environment requires that the research conducted be well-defined and reproducible, and that 
effective methods be developed and applied to (1) estimate the exposure of humans, wildlife, 
and other ecological receptors to source material; (2) assess effects on human health and 
ecosystems of both occupational and environmental exposure; and (3) characterize, assess, 
and manage the risks associated with exposure. 
While the NRC asserts the need for additional EHS research, it does not quantify how much more 
is needed. Clayton Teague, director of the NNCO, has testified that the current level of 
investment in EHS research is adequate.84 Many critics from academia, industry, and non-profit 
organizations have argued strongly that the NNI needs a greater level of investment in EHS 
research.85 These critics argue from a variety of perspectives, including the need to: 
•  protect workers, human health, and the environment; 
•  create public faith and confidence in the safety of nanotechnology products; 
•  prevent a problem with one specific nanotechnology product from resulting in a 
loss of public support for all nanotechnology R&D; and 
•  create a predictable and stable regulatory environment. 
This last factor is deemed by some as critical to fostering future nanotechnology investments. 
                                                             
82 The Technology Administration was eliminated in the America COMPETES Act (P.L. 110-69). 
83 Barriers to Nanotechnology Commercialization, College of Business Management, University of Illinois at 
Springfield, September 2007, available at http://www.osec.doc.gov/Report-
Barriers%20to%20Nanotechnology%20Commercialization.pdf Innovation Vital Signs Project, Alliance for Science 
and Technology Research in America, July 2007. http://www.ntis.gov/ta_reports/Report-InnovationVitalSigns.pdf. 
84 Testimony of Clayton Teague, director of the NNCO, hearing, “Environmental and Safety Impacts of 
Nanotechnology: What Research is Needed?” House Committee on Science, November 17, 2005. 
http://commdocs.house.gov/committees/science/hsy24464.000/hsy24464_0.HTM 
85 Ibid. 
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NRC recommendation: 
the NSET Subcommittee [should] create a working group on education and the workforce 
that engages the Department of Education and Department of Labor as active participants. 
The NSET subcommittee has sought, with limited success, greater involvement of the 
Departments of Education and Labor in the subcommittee’s activities. An NSET subcommittee 
working group on education and the workforce has not yet been established. 
With advocates promising the creation of many new jobs—some assert millions—as a result of 
global nanotechnology investments, some have expressed concern that the country must prepare 
students for nanotechnology research, engineering, and production jobs.86 Assessing which 
industries are likely to create such jobs, which skills will be needed, and in what timeframe are 
key challenges. If workers with nanotechnology-specific skills are needed and no workers are 
available domestically (U.S. citizens, resident aliens, or those in the United States on work visas), 
potential employers may opt to establish or move operations outside the United States to tap 
workers with those skills abroad. Conversely, if students are trained for jobs that do not emerge or 
do not emerge in the same timeframe as students are entering the job market, this investment is 
lost. In addition, potential students may be discouraged from pursuing future nanotechnology-
related studies. Close coordination among the Departments of Commerce, Education, and Labor 
might help to align federal education and training efforts better with the labor market for 
nanotechnology workers. 
The 21st Century Nanotechnology R&D Act also directed the NRC to address two other issues in 
its first triennial report: Is molecular self assembly feasible for manufacturing of materials and 
devices at the nanoscale? And, what are the needs for standards, guidelines, or strategies for 
ensuring the responsible development of nanotechnology? 
Molecular Self-Assembly 
Self-assembly is the process by which components (atoms, molecules, or more complex 
structures) form, without external control or direction, an organized structure. For example, water 
molecules dispersed in air in cold temperatures can self-assemble to form snowflakes. Our bodies 
act as self-assemblers, producing a variety of cells as needed (e.g., to repair a damage to the skin 
or produce new blood cells from added nutrients). 
To what extent can molecular self-assembly be used as a tool for nanomanufacturing? On this 
issue, the NRC concluded that molecular self-assembly is feasible for the manufacture of simple 
materials and devices. However, for the manufacture of more sophisticated materials and devices, 
including complex objects produced in large quantities, the NRC found it unlikely that simple 
self-assembly processes will yield the desired results. One major barrier cited is the probability of 
error during assembly as a result of the systems’ complexity. 
                                                             
86 Phillip J. Bond, Under Secretary for Technology, U.S. Department of Commerce, remarks, “Nanotechnology: 
Economic Opportunities, Societal and Ethical Challenges,” NanoCommerce 2003, December 9, 2003. 
http://www.technology.gov/Speeches/PJB_031209.htm Sizing Nanotechnology’s Value Chain, Lux Research, October 
2004. 
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Standards, Guidelines, and Strategies for Ensuring Responsible Development 
of Nanotechnology 
The NRC concluded that it is not possible yet to make a rigorous assessment of the level of 
environmental and health risks posed by engineered nanomaterials and called for further 
development of risk assessment protocols. The NRC report also stated that the need for more 
EHS data requires an expanded research effort to complement dialog on these issues. In addition, 
until reproducible and well-characterized EHS data are available to inform the development of 
rigorous risk-based guidelines and best practices, the NRC found it prudent to recommend use of 
precautionary measures to protect the health and safety of workers, the public, and the 
environment. The NRC report also stressed that addressing the ethical and societal impacts of 
nanotechnology will require an integrated approach among scientists, engineers, social scientists, 
toxicologists, policymakers, and the public. 
The National Nanotechnology Initiative at Five Years: Assessment and 
Recommendations of the National Nanotechnology Advisory Panel, 
President’s Council of Advisors on Science and Technology87 
This report presents the findings of the first biennial review of the NNI by the President’s Council 
of Advisors on Science and Technology’s, acting as the National Nanotechnology Advisory Panel, 
as mandated by the 21st Century Nanotechnology R&D Act of 2003. The PCAST report finds that 
the United States is the acknowledged leader in nanotechnology R&D, but the U.S. leadership 
position is under increasing competitive pressure from growing public and private investments 
around the world. The report states that the federal investment in the NNI has been well-spent, the 
United States is well-positioned to maintain global leadership going forward, and continued 
robust funding is important for long-term U.S. economic well-being and national security. This 
assessment of the U.S. leadership position is founded not on sales, growth, or market share of 
commercial products—common measures of global competitiveness for established products—
but rather on metrics that may serve as early indicators of potential innovation, such as the U.S. 
share of scientific publications and patents. The use of such metrics may not be universally 
accepted as predictive of leadership position. Technological leadership—or even leadership in 
innovation—does not ensure that the economic benefits from such leadership will accrue to the 
United States. Companies may choose to manufacture products or conduct other value-added 
activities outside the United States. If the assessment of national competitiveness is expanded to 
include the value-added activities and jobs generated or retained within the United States, then 
the metrics for assessing leadership might change. 
The PCAST report acknowledges that there are potential environmental and health risks 
associated with nanotechnology, but finds that the NNI is directing appropriate attention and 
adequate resources to the research that will ensure the protection of the public and the 
environment. Nanotechnology products should not be immune from regulation, according to the 
report, but such regulation must be rational and based on science, not on perceived fears. The 
PCAST report states that strong communication exists among the NNI agencies responsible for 
research and regulation. The PCAST report contains four recommendations for the NNI: 
                                                             
87 The National Nanotechnology Initiative at Five Years: Assessment and Recommendations of the National 
Nanotechnology Advisory Panel, President’s Council of Advisors on Science and Technology, May 2005, available at 
http://www.nano.gov/html/res/FINAL_PCAST_NANO_REPORT.pdf. 
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PCAST recommendation: 
To further facilitate technology transfer from the lab to the marketplace, the NNI should 
expand its interaction with industry, increase federal-state coordination, and improve 
knowledge management of and access to NNI assets, such as user facilities and 
instrumentation. 
The NSET subcommittee’s National Innovation and Liaison with Industry (NILI) working group 
was established to facilitate NNI interactions with industry, and with state and local 
nanotechnology initiatives. The NILI working group’s limited resources and agency participation 
have hindered its ability to conduct more extensive and sustained outreach.88 Due to the structure 
and resource allocation of the NNI, the initiative’s engagements with industry and with state and 
local initiatives are largely limited to single agency or laboratory interactions and to public 
engagement activities, such as speeches and information on the NNI website.89 
PCAST recommendation: 
The NNI should continue its efforts to understand the possible toxicological effects of 
nanotechnology and where harmful human or environmental effects are proven, pertinent 
federal agencies should apply appropriate regulatory mechanisms. There should be strong 
interagency and international collaboration on this issue to eliminate unnecessary duplication 
of research efforts and to ensure wide dissemination of information. Since exposure to 
nanomaterials is most likely to occur during the manufacturing process, research on potential 
hazards associated with workplace exposure must be given the highest priority. 
With respect to collaboration on EHS issues, the NSET subcommittee’s National Environmental 
and Health Implications (NEHI) working group is the primary EHS coordination mechanism for 
participating NNI agencies. The Global Issues in Nanotechnology (GIN) working group works 
with the NEHI working group on international collaboration on EHS issues. The NIOSH has 
published several documents addressing concerns about workplace exposure to nanoparticles. 
Approaches to Safe Nanotechnology: An Information Exchange With NIOSH was intended to 
provide the best currently available knowledge on nanoparticle toxicity and control and to solicit 
input from the stakeholder community.90 Progress Toward Safe Nanotechnology in the Workplace 
details the work of NIOSH’s Nanotechnology Research Center from 2004 through 2006.91 In 
December 2007, NIOSH released interim guidance concerning the medical screening of workers 
potentially exposed to engineered nanoparticles during the manufacture and industrial use of 
nanomaterials. The NIOSH says that the document is intended to “generate discussion, fill the 
current knowledge gap, and provide interim recommendations until further scientific information 
becomes available.”92 The NIOSH is currently seeking public comment on this guidance. 
                                                             
88 Private telephone and e-mail communication with Sean Murdock, executive director of the NanoBusiness Alliance, 
February 4, 2008. 
89 Ibid. 
90 Approaches to Safe Nanotechnology: An Information Exchange with NIOSH, National Institute for Occupational 
Safety and Health, July 2006. 
91 Progress Toward Safe Nanotechnology in the Workplace, National Institute for Occupational Safety and Health, June 
2007. 
92 NIOSH Update: NIOSH Draft Offers Interim Guidance on Medical Screening of Workers Potentially Exposed to 
Engineered Nanoparticles, National Institute for Occupational Safety and Health, December 13, 2007. 
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With respect to regulatory issues associated with nanotechnology, see CRS Report RL34332, 
Engineered Nanoscale Materials and Derivative Products: Regulatory Challenges, by Linda-Jo 
Schierow. 
PCAST recommendation: 
The NNI should establish relationships with the Department of Education and Department of 
Labor to develop education and training systems to support the Nation’s technical 
proficiency in areas related to nanotechnology. 
The PCAST report’s recommendation is similar to the recommendation made by the NRC and is 
discussed earlier in this paper. 
PCAST recommendation: 
The NNI must support research aimed at understanding the societal implications of 
nanotechnology—including ethical, economic and legal implications—and must actively 
work to inform the public about nanotechnology. The NNI should continue to confront 
societal issues in an open, straightforward, and science-based manner. 
Some critics of the NNI hold deep reservations about the ethical, economic, and legal 
implications of nanotechnology. Some of these concerns are common to many technologies, such 
as the allocation of risk and benefit during manufacturing. For example, a neighborhood located 
near a production facility may bear risks associated with exposure to the byproducts (or products) 
of manufacturing, while gaining few of the benefits. Concerns about possible adverse effects of 
nanoscale particles on human health and the environment resulting from their small particle size 
and unique characteristics may result in increased attention to such costs and benefits with respect 
to nanoscale material production. Currently, nanotechnology EHS risks are unknown and may be 
acute or pose no more risk than other manufacturing processes. 
Privacy rights are another issue associated with the products of nanotechnology. Nanotechnology 
may enable the production of highly sensitive, inexpensive sensors that could be deployed 
ubiquitously in commercial and public settings. While these sensors may allow check-out-free 
purchases from stores, or monitor the environment for toxic substances, critics argue that they 
could also impinge on the privacy rights of individuals if, for example, the sensors could detect 
chemicals related to the use of tobacco, alcohol, or illegal substances without the permission of 
the individual. Such information might be later applied in law enforcement, life insurance, health 
insurance, or employment decisions.93 Others express concern that the economically 
disadvantaged and less educated—both individuals and nations—might be unable to take part in 
the benefits that nanotechnology products could offer.94 
On the legal front, innovations in nanotechnology are already presenting unique challenges to the 
U.S. Patent and Trademark Office (USPTO). For example, U.S. case law generally prohibits 
patenting where the sole element of novelty is a change in size, the characteristic most obviously 
                                                             
93 Moore, Fiona M., “Implications of Nanotechnology Applications: Using Genetics as a Lesson,” Health Law Review, 
Vol. 10, No. 3, 2002. http://www.law.ualberta.ca/centres/hli/pdfs/hlr/v10_3/10.3moorefrm.pdf 
94 Smith, Richard H.,”Social, Ethical, and Legal Implications of Nanotechnology,” Societal Implications of 
Nanoscience and Nanotechnology (The Netherlands:Kluwer Academic Publishers, 2001). 
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associated with nanotechnology.95 In addition, many nanotechnology innovations involve 
multiple disciplines. Since the USPTO structure for examining patents is discipline-based, an 
examiner may not have all of the requisite expertise for the examination, affecting both their 
ability to conduct the examination, and the speed at which it can be done. USPTO also has 
acknowledged the need to accelerate the speed of nanotechnology-related patent applications. 
According to John Doll, Commissioner of Patents, the agency is hampered in its ability to recruit 
and retain patent examiners with the requisite skills to handle nanotechnology patents given the 
“more generous offers [patent examiners get] from the private sector.”96 Doll said that efforts 
have been made to improve hiring and retention at USPTO, and that a new process has been 
established allowing an accelerated examination of applications.97 
Selected Nanotechnology Legislation in the 111th 
Congress 
Title I, Subtitle A, H.R. 5116 (111th Congress)—National 
Nanotechnology Initiative Amendments Act of 2010 
The provisions of Title I, Subtitle A of H.R. 5116 (111th Congress), the National Nanotechnology 
Initiative Amendments Act of 2010, were nearly identical to H.R. 554 (111th Congress) (see “H.R. 
554 (111th Congress)—National Nanotechnology Initiative Amendments Act of 2009” below). 
H.R. 5116 changed the name of the act from the “National Nanotechnology Initiative 
Amendments Act of 2009,” to “National Nanotechnology Initiative Amendments Act of 2010,” 
and removed the term “interdisciplinary” from a provision establishing “green nanotechnology” 
research centers. The Senate removed this title before the bill was enacted. 
H.R. 554 (111th Congress)—National Nanotechnology Initiative 
Amendments Act of 2009 
H.R. 554 (111th Congress), the National Nanotechnology Initiative Amendments Act of 2009, 
was introduced on January 15, 2009, and passed by the House of Representatives on February 11, 
2009. The bill was referred to the Senate Commerce, Science, and Transportation Committee on 
February 12, 2009. The purpose of the bill was to authorize activities for support of 
nanotechnology research and development and for other purposes. Among its provisions, the bill 
would have amended the 21st Century Nanotechnology Research and Development Act of 2003 
to: 
•  require the NSTC triennial strategic plan to include near-term and long-term 
objectives, the anticipated timeframe for achieving near-term objectives, and 
metrics for assessing progress; cooperative and collaborative activities in R&D 
                                                             
95 Nanotechnology Patents: Issues for Nanotechnology Inventions, Dorsey and Whitney, LLP, May 9, 2005. 
96 Doll, John, Commissioner of Patents, U.S. Patent and Trademark Office, Letter to the Editor, Small Times, April 23, 
2007. http://www.smalltimes.com/Articles/Article_Display.cfm?ARTICLE_ID=290818&p=109 
97 Ibid. 
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and technology transition supported by the states; and proposed research in areas 
of national priority; 
•  require the NSTC annual nanotechnology report supplementing the President’s 
budget request to include a breakout of spending for the development and 
acquisition of research facilities and instrumentation for each program 
component area, and a breakout of spending on all activities related to ethical, 
legal, environmental, and societal implications; 
•  direct NNP agencies to support the activities of committees involved in the 
development of standards for nanotechnology and allow agencies to reimburse 
the travel costs of scientists and engineers who participate in activities of such 
committees; 
•  direct the agencies to fund the National Nanotechnology Coordination Office, 
and to do so in proportion to each agency’s share of the previous year’s NNP 
budget; 
•  require the NNCO to develop and maintain a publicly accessible database of 
projects funded under the Environmental, Health, and Safety, the Education and 
Societal Dimensions, and the Nanomanufacturing program component areas; 
•  require the NNCO to develop, maintain, and publicize information on 
nanotechnology facilities supported by the NNP, including at a minimum the 
terms and conditions for the use of each facility, a description of the capabilities 
of the instruments and equipment available for use at the facility, and a 
description of the technical support available to assist users of the facility; 
•  require the establishment of a National Nanotechnology Advisory Panel (NNAP) 
“as a distinct entity.” Currently, under the provisions of presidential Executive 
Order 13349, the President’s Council of Advisors on Science and Technology 
serves as the NNAP;98 
•  direct the NNCO to enter into an arrangement with the National Research 
Council to conduct a triennial review of the NNP, and authorizes funds for 
FY2010, FY2011, and FY2012; and 
•  define nanotechnology as “the science and technology that will enable one to 
understand, measure, manipulate, and manufacture at the nanoscale, aimed at 
creating materials, devices, and systems with fundamentally new properties or 
functions,” and define nanoscale as “one or more dimensions of between 
approximately 1 and 100 nanometers.” 
In addition, the bill would have: 
•  required the designation of a White House Office of Science and Technology 
Policy associate director to serve as the “Coordinator for Societal Dimensions of 
Nanotechnology” and would charge the coordinator with convening and chairing 
a panel of federal agency representatives and others to develop, maintain, 
implement, and monitor an annual EHS research plan that includes, among other 
things, standards related to nanotechnology nomenclature; standards for methods 
                                                             
98 Executive Order 13349 is available at http://edocket.access.gpo.gov/cfr_2005/janqtr/3CFR13349.htm. 
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and procedures for detecting, measuring, monitoring, sampling, and testing 
engineered nanoscale materials for environmental, health, and safety impacts; 
and standard reference materials for EHS testing; 
•  required the National Science Foundation to provide grants to establish 
Nanotechnology Education Partnerships to recruit and help prepare secondary 
school students to pursue postsecondary level courses of instruction in 
nanotechnology; 
•  directed the NSTC to establish an Education Working Group under the NSET 
Subcommittee to coordinate, prioritize, and plan NNP educational activities; 
•  directed certain NNP agencies to provide companies access to their supported 
facilities to assist in the development of prototypes of nanoscale products, 
devices, or processes for determining proof of concept; 
•  directed NNP agencies to encourage nanotechnology-related submissions to their 
Small Business Innovation Research (SBIR) and Small Business Technology 
Transfer (STTR) programs; 
•  directed NIST to encourage nanotechnology-related submissions to its 
Technology Innovation Program (TIP), and directs the TIP advisory Board to 
provide advice to NIST to accomplish this, and to provide an assessment of the 
adequacy of TIP resources allocated to nanotechnology related projects; 
•  directed the NSTC to actively pursue industry liaison groups for all industries; 
•  directed the NNP to coordinate and leverage federal investments with 
nanotechnology research, development, and technology transition initiatives 
supported by the States; 
•  directed the NNP to support nanotechnology R&D activities directed toward 
application areas that have the potential for significant contributions to national 
economic competitiveness and for other significant societal benefits, such as 
nano-electronics, energy efficiency, health care, and water remediation and 
purification; 
•  directed the NNP to support research on the development of instrumentation and 
tools required for the rapid characterization of nanoscale materials and for 
monitoring of nanoscale manufacturing processes, and to support approaches and 
techniques for scaling the synthesis of new nanoscale materials to achieve 
industrial-level production rates; and 
•  directed certain NNP-supported interdisciplinary research centers to support 
research on methods and approaches to environmentally benign nanoscale 
products and nanoscale manufacturing processes, as well as related technology 
transfer and education activities. 
S. 1482 (111th Congress)—National Nanotechnology Amendments 
Act of 2009 
S. 1482 (111th Congress), the National Nanotechnology Amendments Act of 2009, was 
introduced on July 21, 2009, and referred to the Senate Commerce, Science, and Transportation 
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Committee. The purpose of the bill was to reauthorize the 21st Century Nanotechnology Research 
and Development Act and to expand the scope of the National Nanotechnology Program (NNP).  
Among its provisions, the bill would have: 
•  required the NNP to solicit and draw upon the perspectives of the industrial 
community to promote the rapid commercial development of nanoscale-enabled 
devices, systems, and technologies and to coordinate research in determining the 
key physical and chemical characteristics of nanoparticles and nanomaterials that 
may pose environmental, health, and safety risks; 
•  required the NNCO and other appropriate agencies and councils to issue 
guidance to agencies that describes a strategy for transitioning research into 
commercial products and technologies and how the program will coordinate or 
conduct research on the environmental, health, and safety issues related to 
nanotechnology; 
•  required the NSTC triennial strategic plan to include near-term and long-term 
objectives, the anticipated timeframe for achieving near-term objectives, and 
metrics for assessing progress; cooperative and collaborative activities in R&D 
and technology transition supported by the states; how the NNP intends to 
encourage and support interdisciplinary research; and proposed research in areas 
of national priority; 
•  encouraged joint interagency solicitation of grant applications in high priority, 
multi-disciplinary research areas; 
•  required participating agencies to support the activities of the committees of 
standards setting bodies involved in the development of standards for 
nanotechnology; 
•  required each participating agency to provide funds to support the work of the 
NNCO. Authorizes appropriations to: (1) NIST for the development of 
nanotechnology standards; and (2) NSF, for use by the NNCO, to develop and 
maintain a public information database of NNP projects in EHS; education; 
public outreach; ethical, legal, and other societal issues; and of nanotechnology 
facilities accessible for use by individuals from academia and industry; 
•  made the National Nanotechnology Advisory Panel (NNAP) a distinct entity, and 
requires the NNAP to establish a subpanel to enable it to assess whether societal, 
ethical, legal, environmental, and workforce concerns are adequately addressed 
by the NNP; 
•  revised provisions for triennial external review of the NNP; 
•  required the designation of a “coordinator for societal dimensions of 
nanotechnology,” within OSTP, to convene a panel to develop a research plan, 
and requires the coordinator to enter into an arrangement with the National 
Science Board to create a report that identifies the broad goals and needs of EHS 
researchers; 
•  directed the NSTC to establish an interagency Education Working Group to 
coordinate, prioritize, and plan formal and informal educational activities 
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supported under the NNP, including activities to help participants understand the 
EHS implications of nanotechnology; 
•  provided for one or more grants to establish Nanotechnology Education 
Partnerships to recruit and help prepare secondary school students to pursue 
postsecondary level courses in nanotechnology; 
•  required agencies supporting nanotechnology research facilities to provide access 
to representatives from industry and other stakeholders for the transfer of 
research results or assist in developing proof-of-concept prototypes of nanoscale 
products, devices, or processes; 
•  directed NIST, in its Technology Innovation Program, and all agencies with 
Small Business Innovation Research (SBIR) and Small Business Technology 
Transfer (STTR) programs, to encourage the submission of nanotechnology 
related grant proposals;  
•  set, for the NNP, the objective of establishing industry liaison groups for all 
industry sectors that would benefit from nanotechnology applications; 
•  required coordination and leveraging of federal investments with nanotechnology 
research, development, and technology transition initiatives supported by state 
governments; 
•  required the NNP to support nanotechnology R&D in areas of national 
importance (e.g., economic competitiveness, energy production, water 
purification, agriculture, and health care; in environmental, health, and safety 
research on the risks of nanoparticles) and in ethical, legal, and societal issues 
related to nanotechnology; 
•  required the NNP to support a wide array of research in support of 
nanomanufacturing; 
•  required the director of the NNCO to review and report on nanomanufacturing 
research and research facilities; 
•  required an NNAP review of the nanomanufacturing program component area 
and the capabilities of nanotechnology research facilities supported by the NNP; 
•  set forth provisions regarding NNP nanoscale characterization and metrology 
research; and 
•  required deliberative public input in the decision making processes affecting 
policies for the research, development, and use of nanotechnology, and 
authorizes $2.0 million for the NNCO to carry out this responsibility. 
S. 596 (111th Congress)—Nanotechnology Innovation and Prize 
Competition Act of 2009 
S. 596 (111th Congress), the Nanotechnology Innovation and Prize Competition Act of 2009, was 
introduced on March 16, 2009, and referred to the Senate Commerce, Science, and Transportation 
Committee. The purpose of the bill was to establish an award program to honor achievements in 
nanotechnology. Under the bill, the Department of Commerce’s National Institute of Standards 
and Technology is directed to award prizes to individuals and companies for achievement in one 
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or more of the following areas: improvement of the environment, consistent with EPA’s Twelve 
Principles of Green Chemistry; development of alternative energy that has the potential to lessen 
the dependence of the United States on fossil fuels; and/or improvement of human health, 
consistent with regulations promulgated by the FDA. The bill would have authorized financial 
prizes for being the first to achieve a specific criteria, as well as recognition prizes, made as part 
of the previously established National Technology and Innovation Medal award program. The bill 
would have authorized $2,000,000 annually for the financial prizes as well as $750,000 annually 
for administration of the prize competitions. 
H.R. 820 (111th Congress)—Nanotechnology Advancement and 
New Opportunities Act 
H.R. 820 (111th Congress), the Nanotechnology Advancement and New Opportunities Act, was 
introduced on February 3, 2009, and referred to four House committees: the Committee on 
Science and Technology, the Committee on Energy and Commerce, the Committee on Ways and 
Means, and the Committee on Homeland Security. The purpose of the bill was to ensure the 
development and responsible stewardship of nanotechnology. The bill would have: 
•  established a $100 million Nanomanufacturing Investment Partnership at the 
Department of Commerce to work with private investors to advance the 
commercialization of nanomanufacturing technologies and to increase the 
commercial application of federally supported research results; 
•  established a 15% tax credit, taken over five years, for the purchase of up to $10 
million of stock in qualified nanotechnology companies; and 
•  established a grant program within the DOC to support the establishment and 
development of nanotechnology incubators by non-profit entities and degree-
granting institutions; 
•  required the Director of the NNCO to prepare a report to Congress on a 
nanotechnology research strategy for government and industry that will ensure 
the development and responsible stewardship of nanotechnology; 
•  provided a tax credit of 50% for nanotechnology education and training expenses 
for businesses and individuals; 
•  authorize an annual appropriation of $15 million for FY2010 through FY2013 for 
the NSF to conduct a grant program for the development of curriculum materials 
for interdisciplinary nanotechnology courses at institutions of higher education; 
•  directed the NSF to establish, through its Advanced Technological Education 
program, a program to encourage manufacturing companies to enter into 
partnerships with occupational training centers for the development of training to 
support nanomanufacturing; and 
•  directed the Secretary of Energy to submit a report to Congress containing a 
strategy for increasing interaction among scientists and engineers at DOE 
national laboratories and the informal science education community to prepare 
appropriate exhibits for school age children and the general public. 
In addition, the bill would have amended the 21st Century Nanotechnology Research and 
Development Act of 2003 to: 
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•  authorize $10 million for the NSF to establish a center for the development of 
computer-aided design tools for nanotechnology applications; 
•  authorize an annual appropriation of $30 million for the DOE to conduct a grant 
program for nanotechnology research to address the need for “clean, cheap, 
renewable energy;” 
•  authorize an annual appropriation of $30 million for the EPA for a grant program 
for nanotechnology research to address technologies for the remediation of 
pollution and other environmental protection technologies; 
•  authorize an annual appropriation of $30 million for the DHS to conduct a grant 
program for nanotechnology research to address the need for sensors and 
materials related to homeland security needs; and 
•  authorize an annual appropriation of $30 million for the DHHS to conduct a 
grant program for nanotechnology research to address health-related applications. 
H.R. 2647 (111th Congress)—National Defense Authorization Act 
for Fiscal Year 2010 
Section 242 of the National Defense Authorization Act for Fiscal Year 2010 (H.R. 2647, P.L. 111-
84) amends the Department of Defense’s nanotechnology reporting responsibilities to align with 
those required of other agencies under the 21st Century Nanotechnology Research and 
Development Act (P.L. 108-153). H.R. 2647 was signed into law on October 28, 2009. 
S. 3117 (111th Congress)—Promote Nanotechnology in Schools Act 
S. 3117 (111th Congress), the Promote Nanotechnology in Schools Act, was introduced on March 
15, 2010, and referred to the Senate Committee on Health, Education, Labor, and Pensions. The 
purpose of the bill was to strengthen the capacity of eligible institutions (i.e., secondary schools, 
community colleges, two-year and four-year institutions of higher education, and informal 
learning science centers) to provide instruction in nanotechnology. The bill would have 
authorized a program at the National Science Foundation for this purpose that would offer 
eligible institutions grants of up to $400,000 (subject to a 25% match from non-federal sources) 
to assist in the purchase and maintenance of nanotechnology equipment and software, to develop 
and provide educational services, and to support teacher education and certification. The bill 
would have authorized $15 million for FY2010 and “such sums as may be necessary” for FY2011 
through FY 2013. 
H.R. 4502 (111th Congress)—Nanotechnology Education Act 
H.R. 4502 (111th Congress), the Nanotechnology Education Act, was introduced on February 19, 
2010, and referred to the House Committee on Science and Technology’s Subcommittee on 
Research and Science Education. The purpose of the bill was to strengthen the capacity of eligible 
institutions (i.e., secondary schools, community colleges, four-year institutions of higher 
education, and informal learning science centers) to provide instruction in nanotechnology. The 
bill would have authorized a program for this purpose at the National Science Foundation that 
would offer eligible institutions grants of up to $400,000 (subject to a 25% match from non-
federal sources) to assist in the purchase and maintenance of nanotechnology equipment and 
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software, to develop and provide educational services, and to support teacher education and 
certification. The bill would have authorized $40 million for FY2011 and “such sums as may be 
necessary” for FY2012 through FY 2014. 
S. 2942 (111th Congress)—Nanotechnology Safety Act of 2010 
S. 2942 (111th Congress), the Nanotechnology Safety Act of 2010, was introduced on January 21, 
2010, and referred to the Senate Committee on Health, Education, Labor, and Pensions. The bill 
would have required the Secretary of Health and Human Services to establish within 180 days a 
program for the scientific investigation of nanoscale materials included or intended for inclusion 
in FDA-regulated products, to address the potential toxicology of such materials, the effects of 
such materials on biological systems, and interaction of such materials with biological systems. 
The bill would have authorized $25 million per year for fiscal years 2011 to 2015. 
H.R. 5786 (111th Congress)—Safe Cosmetics Act of 2010 
H.R. 5786 (111th Congress), the Safe Cosmetics Act of 2010, was introduced on July 20, 2010, 
and referred to the House Committee on Energy and Commerce and the House Committee on 
Education and Labor. The bill would have required the Secretary of Health and Human Services 
to monitor developments in the scientific understanding of any adverse health effects related to 
the use of nanotechnology in the formulation of cosmetics and to consider scale specific hazard 
properties of ingredients when conducting or reviewing safety substantiation of cosmetic 
ingredients. In addition, the bill would have required manufacturers to submit to the Secretary a 
statement for each cosmetic that includes an ingredient list, including the particle size of any 
nanoscale cosmetic ingredients. The bill would also have given the Secretary authority to require 
labeling of cosmetics disclosing the use of nanoscale ingredients. 
Concluding Observations 
Many expect nanotechnology to bring significant economic and societal returns. The United 
States was the first government to launch a national-level nanotechnology program and has 
invested more than any other nation. As a result of this focus and these sustained investments, 
many experts believe that the United States enjoys a technological leadership position in 
nanotechnology. Other nations are investing heavily and some industrialized and emerging 
economies have formidable capabilities in nanotechnology. Assessments of the National 
Nanotechnology Initiative have concluded that the effort is well-managed and has been successful 
in achieving its objectives so far. However, these assessments have recognized that the NNI faces 
a variety of challenges in ensuring that the full promise of nanotechnology is realized and that the 
United States remains the global leader in nanoscale science, engineering, and technology. 
Congress may choose to address some or many of the issues addressed in the body of this report 
in the course of deliberation on the reauthorization of the 21st Century Nanotechnology R&D Act 
of 2003 or, alternatively, in separate legislation. 
The 21st Century Nanotechnology R&D Act’s funding authorizations extended through FY2008. 
The 109th Congress and 110th Congress considered legislation to reauthorize the program. If the 
112th Congress opts to consider reauthorization of the act, some of the issues it may wish to 
consider include budget authorization levels for the covered agencies; R&D funding levels, 
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priorities, and balance across the program component areas; administration and management of 
the NNI; translation of research results and early-stage technology into commercially viable 
applications; environmental, health, and safety issues; ethical, legal, and societal implications; 
education and training for the nanotechnology workforce; metrology, standards, and 
nomenclature; public understanding; and international dimensions. Consideration may also be 
given to the establishment of an independent review panel and to coordination of the timing for 
the NNAP assessment, the NRC assessment, and the NSET subcommittee’s strategic plan for the 
NNI. 
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Appendix A. Selected Reports on the National 
Nanotechnology Initiative 
Reports of the Nanoscale Science, Engineering, and Technology 
Subcommittee of the National Science and Technology Council 
The National Nanotechnology Initiative: Research and Development Leading to a Revolution in 
Technology and Industry, Supplement to the President’s FY2010 Budget. May 2009. 
The National Nanotechnology Initiative: Research and Development Leading to a Revolution in 
Technology and Industry, Supplement to the President’s FY2009 Budget. September 2008. 
National Nanotechnology Initiative Fiscal Year 2009 Budget Summary & Highlights. February 
2008 
Strategy for Nanotechnology-Related Environmental, Health, and Safety Research. February 
2008 
The National Nanotechnology Initiative Strategic Plan. December 2007. 
The National Nanotechnology Initiative: Research and Development Leading to a Revolution in 
Technology and Industry, Supplement to the President’s FY2008 Budget. July 2007. 
The National Nanotechnology Initiative: Environmental, Health, and Safety Research Needs for 
Engineered Nanoscale Materials. September 2006. 
The National Nanotechnology Initiative: Research and Development Leading to a Revolution in 
Technology and Industry, Supplement to the President’s FY2007 Budget. July 2006. 
The National Nanotechnology Initiative: Research and Development Leading to a Revolution in 
Technology and Industry, Supplement to the President’s FY2006 Budget. March 2005. 
The National Nanotechnology Initiative Strategic Plan. December 2004. 
Nanotechnology in Space Exploration. August 2004. 
Nanoscience Research for Energy Needs. Report from a workshop held in March 2004. 
Instrumentation and Metrology for Nanotechnology. Report from a workshop held in January 
2004. 
Nanotechnology: Societal Implications-Maximizing Benefits for Humanity. Report from a 
workshop held in December 2003. 
Nanobiotechnology. Report from a workshop held in October 2003. 
Regional, State, and Local Initiatives in Nanotechnology. Report from a workshop held in 
September-October 2003. 
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National Nanotechnology Initiative: Research and Development Supporting the Next Industrial 
Revolution, Supplement to the President’s FY2004 Budget. August 2003. 
Nanotechnology and the Environment. Report from a workshop held in May 2003. 
National Nanotechnology Initiative: The Initiative and Its Implementation Plan, Detailed 
Technical Report Associated with the Supplemental Report to the President’s FY2003 
Budget. June 2002. 
National Nanotechnology Initiative: The Initiative and Its Implementation Plan, Detailed 
Technical Report Associated with the Supplemental Report to the President’s FY2001 
Budget. July 2000. 
Report of the Interagency Working Group on Nanoscience, 
Technology, and Engineering (NSET Subcommittee Predecessor) 
Nanotechnology: Shaping the World Atom by Atom. 1999. 
Agency Reports 
NIOSH Update: NIOSH Draft Offers Interim Guidance on Medical Screening of Workers 
Potentially Exposed to Engineered Nanoparticles, National Institute for Occupational Safety 
and Health. December 2007. 
Progress Toward Safe Nanotechnology in the Workplace, National Institute for Occupational 
Safety and Health. June 2007. 
Approaches to Safe Nanotechnology in the Workplace, National Institute for Occupational Safety 
and Health. July 2006. 
Nanoscale Science, Engineering, and Technology in DOE’s Office of Basic Energy Sciences, 
U.S. Department of Energy. February 2003. 
External Reviews 
A Matter of Size: Triennial Review of the National Nanotechnology Initiative, National Research 
Council. 2006. 
The National Nanotechnology Initiative at Five Years: Assessment and Recommendations of the 
National Nanotechnology Advisory Panel, President’s Council of Advisors on Science and 
Technology (acting as the National Nanotechnology Advisory Panel). May 2005. 
Small Wonders, Endless Frontiers: A Review of the National Nanotechnology Initiative, National 
Research Council. June 2002. 
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Appendix B. List of NNI and 
Nanotechnology-Related Acronyms 
ASTRA 
Alliance for Science and Technology Research in America 
CNST 
Center for Nanoscale Science and Technology 
CS Committee 
on 
Science 
CT Committee 
on 
Technology 
CSREES 
Cooperative State Research, Education, and Extension Service 
DHHS 
Department of Health and Human Services 
DHS 
Department of Homeland Security 
DOC Department 
of 
Commerce 
DOD 
Department of Defense 
DOE Department 
of 
Energy 
DOJ Department 
of 
Justice 
DOT Department 
of 
Transportation 
EHS 
Environmental, health, and safety 
ELSI 
Ethical, legal, and societal implications 
EPA 
Environmental Protection Agency  
EOP 
Executive Office of the President 
EPSCoR 
Experimental Program to Stimulate Competitive Research 
FHWA Federal 
Highway 
Administration 
GIN 
Global Issues in Nanotechnology working group  
ISO 
International Standards Organization 
IWGN 
Interagency Working Group on Nanotechnology 
NASA 
National Aeronautics and Space Administration 
NCI National 
Cancer 
Institute 
NEHI  
National Environmental and Health Implications working group  
NGO Non-governmental 
organization 
NIH 
National Institutes of Health 
NILI 
National Innovation and Liaison with Industry working group 
NIOSH 
National Institute of Occupational Safety and Health 
NIST 
National Institute of Standards and Technology 
NNAP 
National Nanotechnology Advisory Panel 
NNCO 
National Nanotechnology Coordination Office 
NNI 
National Nanotechnology Initiative 
NNIN 
National Nanotechnology Infrastructure Network 
NNN National 
Nanomanufacturing 
Network 
NNP National 
Nanotechnology 
Program 
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NPEC 
Nanotechnology Public Engagement and Communications working group  
NRC 
National Research Council 
NSET 
Nanoscale Science, Engineering, and Technology subcommittee  
NSF 
National Science Foundation 
NSEC 
Nanoscale Science and Engineering Center 
NSRC 
Nanoscale Science Research Centers 
NSTC 
National Science and Technology Council 
OECD 
Organization for Economic Cooperation and Development 
OMB 
Office of Management and Budget 
OSTP 
Office of Science and Technology Policy 
PCA Program 
Component 
Areas 
PCAST 
President’s Council of Advisors on Science and Technology 
R&D 
Research and development 
SBIR 
Smal  Business Innovation Research 
STTR 
Smal  Business Technology Transfer Research 
TSA 
Transportation Security Administration 
USDA 
U.S. Department of Agriculture 
USPTO 
U.S. Patent and Trademark Office 
 
Author Contact Information 
 
John F. Sargent Jr. 
   
Specialist in Science and Technology Policy 
jsargent@crs.loc.gov, 7-9147 
 
 
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